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Alzheimer's and Parkinson's Disease - Global Strategic Business Report

Price:
USD $3,950.00
ISBN/SKU #:
GIA-MCP1704
Research Group:
Global Industry Analysts
Date of Publication:
May 2008
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Summary

This report analyzes the worldwide markets for Alzheimer and Parkinson Disease in Millions of US$. The Major product segments Analyzed are Anti-Alzheimer Disease Drugs (Cholinesterase Inhibitors, & NMDARA), and Anti-Parkinson Disease Drugs (Dopaminergic Agents, Dopamine Agonists, & Other PD Drugs (Include COMT Inhibitors, MOA-B Inhibitors, and Dopamine Amplifiers). The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, and Rest of World. Annual forecasts are provided for each region for the period of 2000 through 2015. The report profiles 87 companies including many key and niche players worldwide such as Boehringer Ingelheim, Bristol-Myers Squibb Co., Eisai Inc., Eli Lilly and Company, Forest Pharmaceuticals, GlaxoSmithKline PLC, H. Lundbeck A/S, Merz Pharmaceuticals GMBH, Novartis AG, Ortho-McNeil Neurologics, Inc., Pfizer Inc., Roche, Shire Pharmaceuticals Group PLC, and Valeant Pharmaceuticals International. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

TABLE OF CONTENTS:

ALZHEIMER'S AND PARKINSON'S DISEASES						MCP-1704
A GLOBAL STRATEGIC BUSINESS REPORT


                                              CONTENTS


  I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
      Study Reliability and Reporting Limitations                       I-1
      Disclaimers                                                       I-2
      Data Interpretation & Reporting Level                             I-2
       Quantitative Techniques & Analytics                              I-3
      Product Definitions and Scope of Study                            I-3
       Product Segments                                                 I-3
        Anti-Alzheimer's Disease Drugs                                  I-3
         Cholinesterase Inhibitors                                      I-3
         NMDARA                                                         I-4
        Anti-Parkinson's Disease Drugs                                  I-4
         Dopaminergic Agents (Levodopa/Carbidopa)                       I-4
         Dopamine Agonists                                              I-4
         Other PD Drugs (Include COMT Inhibitors, MOA-B Inhibitors,
          and Dopamine Amplifiers)                                      I-5
           COMT Inhibitors                                              I-5
           MAO-B Inhibitors                                             I-5
           Dopamine Amplifiers                                          I-5


 II. EXECUTIVE SUMMARY

  1. Outlook                                                            II-1
      Current and Future Analysis                                       II-1

  2. Neurodegenerative Diseases Market - A Brief Overview               II-2
      Key Brands in NDD Market                                          II-2
       Table 1: Leading Drugs in the Global Neurodegenerative
       Disease Market (2004): Percentage Breakdown by Sales Revenues
       for Razadyne, Aricept, Exelon, Namenda, Sifrol / Mirapex,
       Requip, Cabaser, Madopar, Siemet, Permax, and Others
       (includes corresponding Graph/Chart)                             II-3
      Factors Affecting Market                                          II-3
       Major Growth Drivers                                             II-3
       Major Growth Inhibitors                                          II-3
      Market Trends                                                     II-4
       High Prevalence Rates Drive Market Growth                        II-4
       Rapid Growth of Ageing Population                                II-4
       Price Hikes and Government Caps                                  II-4
       Combination Therapy Gaining Ground                               II-5
       Research & Development                                           II-5
       Future Holds Promise                                             II-5

  3. Alzheimer's Market Overview                                        II-6
      A Peek at Anti-AD Drug Market                                     II-6
      Impact of Dementia                                                II-6
      Epidemiology                                                      II-6
       Table 2: World Alzheimer's Disease Prevalence for Years 2000
       through 2010: Number of Patients in Thousands by
       Country/Region for US, Canada, Japan, Europe (Germany,
       France, UK, Italy, Spain, and Rest of Europe), and Rest of
       World (includes corresponding Graph/Chart)                       II-7

       Table 3: Alzheimer's Disease Prevalence in Top Seven
       Countries (US, Japan, Germany, France, UK, Italy, and Spain)
       for Years 2001 through 2010: Number of Patients (in '000)
       Diagnosed and Treated by Disease Severity (Mild Stage,
       Moderate Stage, and Late Stage) (includes corresponding
       Graph/Chart)                                                     II-8

       Table 4: Alzheimer's Disease Diagnosis in Top Seven Countries
       (2005): Percentage of Diagnosed Patients in the US, Japan,
       Germany, France, Italy, Spain, and the UK (includes
       corresponding Graph/Chart)                                       II-8
      Patient Growth Drivers                                            II-8
      Demographics Spell Opportunities                                  II-8
      High Growth Rates for AD Drugs                                    II-9
       The Impact of Aricept                                            II-9
       Epic of NMDARA                                                   II-9
        Strengths                                                       II-10
        Weaknesses                                                      II-10
       Future Therapies                                                 II-11
       How Successful will the Late Stage Therapies be?                 II-11
      A Geographic Milieu                                               II-11
       US                                                               II-11
       Europe                                                           II-11
       Japan                                                            II-11
      Alternative Drug Delivery Technologies Gaining Ground             II-12
       Transdermal Patch                                                II-12
      Domination of Acetyl Cholinesterase Inhibitors                    II-12
      Dramatic Changes in Market Lie Ahead                              II-12
      Advances in Next-Generation Treatments                            II-12
      Beta Amyloid Hypothesis                                           II-13
      Growth Drivers                                                    II-13
       Ageing Baby Boomers Drive AD Market                              II-13
        Table 5: AD Frequency Rate (%) (includes corresponding
        Graph/Chart)                                                    II-13
       New Hypothesis Enables Effective Treatment                       II-14
       Unmet Medical Needs Drive Market Growth                          II-14
      Growth Inhibitors                                                 II-14
       Link with Other Aliments                                         II-14
       Misdiagnosis                                                     II-14
       Patient Awareness                                                II-14
       Medical Refunds                                                  II-14
      Competitive Landscape                                             II-15
       Pharmaceutical Majors Rule the Market                            II-15
        Eisai/Pfizer                                                    II-15
        Novartis                                                        II-15
        Shire/Johnson & Johnson                                         II-15
        Lundbeck/Forest                                                 II-16
        Ipsen and UCB                                                   II-16
        Table 6: Leading Brands in the Global Anti- Alzheimer's Drug
        Market (2005): Percentage Breakdown by Sales Revenues for
        Aricept, Exelon, Razadyne, Axura, Ebixa, Namenda, and Others
        (includes corresponding Graph/Chart)                            II-16
       Year of Approval of AD Drugs in Leading Countries                II-17
      Compounds in Pipeline                                             II-17
      Outlook for AD Drugs Market                                       II-18

  4. Parkinson's Disease Market Overview                                II-19
      An Alluring Market                                                II-19
      Prevalence                                                        II-19
       Table 7: World Parkinson's Disease Prevalence for Years 2000
       through 2010: Number of Patients in Thousands by
       Country/Region for US, Canada, Japan, Europe (Germany,
       France, UK, Italy, Spain, Rest of Europe), and Rest of World
       (includes corresponding Graph/Chart)                             II-19
      Current Treatments                                                II-20
      New Medicines on the Horizon                                      II-20
      New Findings                                                      II-20
      Product Launches Through 2009                                     II-20
      Dominance of Dopamine Agonists                                    II-20
      Revival Revels in Other Anti-PD Drugs Segment                     II-21
      COMT Inhibitors Growing Fastest                                   II-21
      Key Market Drivers                                                II-21
       Rising Awareness Magnifies Patient Base                          II-21
       Emergence of Dopamine Agonists as First Line Treatment Drives
        Market Growth                                                   II-21
       The Debut of Stalevo                                             II-21
       Unmet Clinical Needs Show Mammoth Prospects                      II-21
      Key Market Inhibitors                                             II-22
       Limitations of Existing Medicines Inhibit Market Growth          II-22
       Under-Diagnosis Restrains Market Potential                       II-22
       Generic Competition from L-Dopa and Carbidopa Curbs Market
        Growth                                                          II-22
       Restricted Term of Dopamine Agonists Usage Delays Market Growth  II-22

  5. Disease Overview                                                   II-23
      Alzheimer's Disease                                               II-23
       Definition                                                       II-23
       The Cause                                                        II-23
       Finding AD                                                       II-23
       Prevention                                                       II-23
       Treatment                                                        II-24
      Parkinson's Disease                                               II-24
       Definition                                                       II-24
       Pathophysiology                                                  II-24
       Diagnosis                                                        II-25
       Prevalence                                                       II-25
       Treatment                                                        II-25
       Surgical Intervention                                            II-25

  6. Drug Classification                                                II-26
      Anti-Alzheimer's' Disease Drugs                                   II-26
       NMDARA                                                           II-26
        Memantine                                                       II-27
       Cholinesterase Inhibitors (ChEIs)                                II-27
        Donepezil (Aricept)                                             II-27
        Rivastigmine (Exelon)                                           II-27
        Galantamine Hydrobromide (Razadyne)                             II-28
        Tacrine (Cognex)                                                II-28
       Other Alternatives                                               II-28
        Vitamin E                                                       II-28
        Estrogen Therapy                                                II-28
        Anti-Inflammatory Drugs                                         II-29
         NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)                 II-29
        Antioxidants                                                    II-29
         Vaccine                                                        II-29
         Gingko Biloba                                                  II-29
         Pure Medical Nicotine                                          II-29
      Anti-Parkinson's Disease Drugs                                    II-29
       Dopaminergic agents                                              II-30
        Levodopa/Carbidopa                                              II-30
       Dopamine Agonists                                                II-30
        Pergolide/Permax                                                II-30
        Bromocriptine/Parlodel                                          II-30
        Ropinirole/Requip                                               II-30
        Pramipexole/Mirapex                                             II-31
        Cabergoline/Dostinex                                            II-31
        Apomorphine/Apokyn                                              II-31
        Other Dopamine Agonists                                         II-31
       Other PD Drugs                                                   II-31
        COMT Inhibitors                                                 II-31
         Tolcapone (Tasmar)                                             II-31
         Entacapone (Comtan)                                            II-32
        MAO-B Inhibitors                                                II-32
        Dopamine Amplifiers                                             II-32
        Anticholinergics                                                II-32

  7. Future Therapies                                                   II-33
      Alzheimer's Disease                                               II-33
       Key Pipeline Products                                            II-33
        Phenserine                                                      II-33
        Ropern                                                          II-33
        Alzhemed                                                        II-34
        MEM 1003                                                        II-34
        Ampakine Compounds                                              II-34
      Parkinson's Disease                                               II-34
       Key Pipeline Products                                            II-34
        Adenosine A2a Antagonist                                        II-35
        Spheramine                                                     II-35
        Safinamide                                                      II-35
        O-1369                                                          II-36

  8. New Findings                                                       II-37
      Risedronate Minimizes Risk of Hip Fractures in PD Patients        II-37
      Researchers Identify New Genes Responsible for AD                 II-37
      Researchers Establish a New Link Between Loneliness and AD        II-37
      Researchers Try to Identify Early Stages of AD                    II-37
      SORL1 - The New Gene Found to be Responsible for AD               II-38
      Scientists Conduct Research Work on CERE-120 Gene Therapy         II-38
      Researchers Find New Snail Toxin for Nervous System Disorders     II-38
      Researchers Study Anti-PD Properties of Nicotine                  II-38
      Researchers Establish New Link Between Pesticides and PD          II-38
      Study Relates AD to the Quantity of Amyloid Protein               II-39
      Researchers Establish Effectiveness of Gene Therapy on AD
       Patients                                                         II-39
      Scientists Use Electric Current to Treat PD Patients              II-39
      Scientists Prove Earlier Assumptions Wrong                        II-39
      Scientists Discover 2 Distinct Types of MCIs                      II-40

  9. Recent Industry Activity                                           II-41
      Eisai Acquires MGI Pharma                                         II-41
      Eli Lilly Begins Phase III Clinical Trial of Alzheimer's
       Disease Treatment                                                II-41
      Merz Licenses Anti-Alzheimer's Drug Technology from TAU           II-41
      Eisai Acquires Morphotek                                          II-41
      Transition Therapeutics Acquires NeuroMedix                       II-41
      Evotec Teams Up with Boehringer Ingelheim                         II-41
      Siemens Signs Partnership Agreement with Wyeth                    II-42
      Digilab Receives Notice of Allowance for New Alzheimer's
       Biomarker                                                        II-42
      Pfizer Joins Forces with Genizon                                  II-42
      Intellect Signs Licensing Agreement with IBL                      II-42
      Boehringer Ingelheim signs R&D agreement with Ablynx              II-42
      Avicena Teams Up with NINDS for Phase III Trial of PD-02          II-43
      Prana Begins Phase II clinical trial for PBT2                     II-43
      Idera Teams Up with Merck                                         II-43
      Merck Signs R&D Agreement with Neuroptix                          II-44
      Neuro-Hitech Takes Over Q-RNA                                     II-44
      Neurogen Inks Licensing Agreement with Wyeth                      II-44
      Acumen Revises License Agreement with Merck                       II-44
      Newron Begins 2nd Phase III clinical trial for Safinamide         II-44
      Newron Inks Global Licensing Agreement with Serono                II-45
      Pfizer Inks License Agreement with TransTech                      II-45
      CeNeS Renews R&D Agreement with Tripos                            II-45
      Athenagen Acquires Zapaq                                          II-45
      Neuren Starts Pre-clinical Studies of Anti-PD Drug - NNZ-2591     II-45
      Teva Receives Health Canada Clearance for Azilect                 II-46
      Valeant Introduces Zelapar Anti-PD Tablets in the US              II-46
      Merck to Halt Further Development of Anti-PD Drug Called
       Sarizotan                                                        II-46
      Amarin Obtains Global Rights for New Apomorphine Formulation      II-46
      FDA Clears Exelon for Parkinson's Disease                         II-46
      Neuropharma Receives German Clearance for Phase 1 Clinical
       Trials of NP031112                                               II-47
      Pfizer Takes Over Rinat                                           II-47
      TorreyPines Begins 2nd Phase-I clinical trial for NGX267          II-47
      Kyowa Hakko Inks Licensing Agreement with Britannia               II-47
      Schwarz Pharma Receives EMEA Clearance for Neupro                 II-47
      Evotec Inks Licensing Agreement with Roche                        II-48
      RheoGene Receives Funds from MJFF                                 II-48
      Eisai Initiates Phase I clinical trial for E2012                  II-48
      Apokyn(R) Receives Approval in North America                      II-48
      FDA Approves Azilect                                              II-48
      Voyager Completes Phase II Study for of Leuprolide Acetate        II-49
      New Discovery for the Treatment of Alzheimer's Disease in Canada  II-49
      Ortho-McNeil Launches Razadyne ER                                II-49
      Flurizan Enters Phase II Clinical Trials                          II-50
      Axonyx Releases Supplementary Results of Phase III Trial for
       Phenserine                                                       II-50
      Predix Pharmaceuticals Starts Phase Ib Trials of 5-HT4 Agonist    II-50
      BrainStorm Pronounces Advantages of GDNF Producing Stem Cells
       in Parkinson's Animal Models                                     II-50
      Predix's PRX-03140 Completes First Clinical Trial in
       Alzheimer's Disease                                              II-51
      Galapagos and Senexis Expand Collaboration                        II-51
      Novartis Joins Forces with Ono to Develop and Market AD
       Transdermal Patch                                                II-51
      Neurologix Posts Interim Results of Phase I Gene Therapy          II-51
      GB Therapeutics Receives License for CHF1512                      II-51
      Alzhemed Begins Phase III Trials                                 II-51
      Newron Commences Phase III Trial With Safinamide                  II-52
      Ceregene Bags FDA Approval for Gene Therapy Alzheimer's Study     II-52
      Memantine Drug Receives Approval from FDA for Treatment of
       Alzheimer's                                                      II-52
      FDA Grants Fast Track Designation                                 II-52
      Ester Neurosciences Joins Forces with Pharmacopeia                II-52

  10. Focus on Select Players                                           II-53
      Boehringer Ingelheim (Germany)                                    II-53
      Bristol-Myers Squibb Co. (USA)                                    II-53
      Eisai Inc. (USA)                                                  II-53
      Eli Lilly and Company (USA)                                       II-54
      Forest Pharmaceuticals (USA)                                      II-54
      GlaxoSmithKline PLC (UK)                                          II-54
      H. Lundbeck A/S (Denmark)                                         II-55
      Merz Pharmaceuticals GMBH (Germany)                               II-55
      Novartis AG (Switzerland)                                         II-55
      Ortho-McNeil Neurologics, Inc. (USA)                              II-56
      Pfizer Inc (US)                                                   II-56
      Roche (Switzerland)                                               II-56
      Shire Pharmaceuticals Group PLC (UK)                              II-56
      Valeant Pharmaceuticals International (USA)                       II-57

  11. Global Market Perspective                                         II-58
      Table 8: World Recent Past, Current & Future Market Analysis
      for Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
      Geographic Region - US, Canada, Japan, Europe, and Rest of
      World Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2000 through 2010 (includes corresponding
      Graph/Chart)                                                      II-58

      Table 9: World Long-term Projections for Anti-Alzheimer's and
      Anti-Parkinson's Disease Drugs by Geographic Region - US,
      Canada, Japan, Europe, and Rest of World Independently
      Analyzed with Annual Sales Figures in US$ Million for Years
      2011 through 2015 (includes corresponding Graph/Chart)            II-59

      Table 10: World 10-Year Perspective for Anti-Alzheimer's and
      Anti-Parkinson's Disease Drugs - Percentage Breakdown of
      Dollar Sales for US, Canada, Japan, Europe, and Rest of World
      Markets for Years 2003, 2008 & 2012 (includes corresponding
      Graph/Chart)                                                      II-60

      Table 11: World Recent Past, Current & Future Market Analysis
      for Anti-Alzheimer's Disease Drugs by Geographic Region - US,
      Canada, Japan, Europe, and Rest of World Independently
      Analyzed with Annual Sales Figures in US$ Million for Years
      2000 through 2010 (includes corresponding Graph/Chart)            II-61

      Table 12: World Long-term Projections for Anti-Alzheimer's
      Disease Drugs by Geographic Region - US, Canada, Japan,
      Europe, and Rest of World Independently Analyzed with Annual
      Sales Figures in US$ Million for Years 2011 through 2015
      (includes corresponding Graph/Chart)                              II-62

      Table 13: World Recent Past, Current & Future Market Analysis
      for Anti-Alzheimer's Disease Drugs by Product Segment
      -Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
      Receptor Antagonists)) Markets Independently Analyzed with
      Annual Sales Figures in US$ Million for Years 2000 through
      2010 (includes corresponding Graph/Chart)                         II-63

      Table 14: World Long-term Projections for Anti-Alzheimer's
      Disease Drugs by Product Segment -Cholinesterase Inhibitors
      and NMDARA (N-methyl, D-Aspartate Receptor Antagonists))
      Markets Independently Analyzed with Annual Sales Figures in
      US$ Million for Years 2011 through 2015 (includes
      corresponding Graph/Chart)                                        II-63

      Table 15: World 10-Year Perspective for Anti-Alzheimer's
      Disease Drugs by Geographic Region - Percentage Breakdown of
      Dollar Sales for US, Canada, Japan, Europe, and Rest of World
      Markets for Years 2003, 2008 & 2012 (includes corresponding
      Graph/Chart)                                                      II-64

      Table 16: World 10-Year Perspective for Anti-Alzheimer's
      Disease Drugs by Product Segment - Percentage Breakdown of
      Dollar Sales for Cholinesterase Inhibitors and NMDARA
      (N-methyl, D-Aspartate Receptor Antagonists)) Markets for
      2003, 2008 & 2012                                                 II-64

      Table 17: World Recent Past, Current & Future Market Analysis
      for Cholinesterase Inhibitors by Geographic Region - US,
      Canada, Japan, Europe, and Rest of World Independently
      Analyzed with Annual Sales Figures in US$ Million for Years
      2000 through 2010 (includes corresponding Graph/Chart)            II-65

      Table 18: World Long-term Projections for Cholinesterase
      Inhibitors by Geographic Region - US, Canada, Japan, Europe,
      and Rest of World Independently Analyzed with Annual Sales
      Figures in US$ Million for Years 2011 through 2015 (includes
      corresponding Graph/Chart)                                        II-66

      Table 19: World 10-Year Perspective for Cholinesterase
      Inhibitors by Geographic Region - Percentage Breakdown of
      Dollar Sales for US, Canada, Japan, Europe, and Rest of World
      Markets for Years 2003, 2008 & 2012 (includes corresponding
      Graph/Chart)                                                      II-67

      Table 20: World Recent Past, Current & Future Market Analysis
      for NMDARA (N-methyl, D-Aspartate Receptor Antagonists)) by
      Geographic Region - US, Canada, Japan, Europe, and Rest of
      World Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2002 through 2010 (includes corresponding
      Graph/Chart)                                                      II-68

      Table 21: World Long-term Projections for NMDARA (N-methyl,
      D-Aspartate Receptor Antagonists)) by Geographic Region - US,
      Canada, Japan, Europe, and Rest of World Independently
      Analyzed with Annual Sales Figures in US$ Million for Years
      2011 through 2015 (includes corresponding Graph/Chart)            II-69

      Table 22: World 9-Year Perspective for NMDARA (N-methyl,
      D-Aspartate Receptor Antagonists)) by Geographic Region -
      Percentage Breakdown of Dollar Sales for US, Canada, Japan,
      Europe, and Rest of World Markets for Years 2004, 2008 & 2012
      (includes corresponding Graph/Chart)                              II-70

      Table 23: World Recent Past, Current & Future Market Analysis
      for Anti-Parkinson's Disease Drugs by Geographic Region - US,
      Canada, Japan, Europe, and Rest of World Independently
      Analyzed with Annual Sales Figures in US$ Million for Years
      2000 through 2010 (includes corresponding Graph/Chart)            II-71

      Table 24: World Long-term Projections for Anti-Parkinson's
      Disease Drugs by Geographic Region - US, Canada, Japan,
      Europe, and Rest of World Independently Analyzed with Annual
      Sales Figures in US$ Million for Years 2011 through 2015
      (includes corresponding Graph/Chart)                              II-72

      Table 25: World Recent Past, Current & Future Market Analysis
      for Anti-Parkinson's Disease Drugs by Product Segment -
      Dopaminergic agents, Dopamine Agonists, and Other PD Drugs
      Markets Independently Analyzed with Annual Sales Figures in
      US$ Million for Years 2000 through 2010 (includes
      corresponding Graph/Chart)                                        II-73

      Table 26: World Long-term Projections for Anti-Parkinson's
      Disease Drugs by Product Segment - Dopaminergic agents,
      Dopamine Agonists, and Other PD Drugs Markets Independently
      Analyzed with Annual Sales Figures in US$ Million for Years
      2011 through 2015 (includes corresponding Graph/Chart)            II-73

      Table 27: World 10-Year Perspective for Anti-Parkinson's
      Disease Drugs by Geographic Region - Percentage Breakdown of
      Dollar Sales for US, Canada, Japan, Europe, and Rest of World
      Markets for Years 2003, 2008 & 2012 (includes corresponding
      Graph/Chart)                                                      II-74

      Table 28: World 10-Year Perspective for Anti-Parkinson's
      Disease Drugs by Product Segment - Percentage Breakdown of
      Dollar Sales for Dopaminergic Agents, Dopamine Agonists, and
      Other PD Drugs Markets for 2003, 2008 & 2012 (includes
      corresponding Graph/Chart)                                        II-74

      Table 29: World Recent Past, Current & Future Market Analysis
      for Dopaminergic Agents by Geographic Region - US, Canada,
      Japan, Europe, and Rest of World Independently Analyzed with
      Annual Sales Figures in US$ Million for Years 2000 through
      2010 (includes corresponding Graph/Chart)                         II-75

      Table 30: World Long-term Projections for Dopaminergic Agents
      by Geographic Region - US, Canada, Japan, Europe, and Rest of
      World Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2011 through 2015 (includes corresponding
      Graph/Chart)                                                      II-76

      Table 31: World 10-Year Perspective for Dopaminergic Agents by
      Geographic Region - Percentage Breakdown of Dollar Sales for
      US, Canada, Japan, Europe, and Rest of World Markets for Years
      2003, 2008 & 2012 (includes corresponding Graph/Chart)            II-77

      Table 32: World Recent Past, Current & Future Market Analysis
      for Dopamine Agonists by Geographic Region - US, Canada,
      Japan, Europe, and Rest of World Independently Analyzed with
      Annual Sales Figures in US$ Million for Years 2000 through
      2010 (includes corresponding Graph/Chart)                         II-78

      Table 33: World Long-term Projections for Dopamine Agonists by
      Geographic Region - US, Canada, Japan, Europe, and Rest of
      World Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2011 through 2015 (includes corresponding
      Graph/Chart)                                                      II-79

      Table 34: World 10-Year Perspective for Dopamine Agonists by
      Geographic Region - Percentage Breakdown of Dollar Sales for
      US, Canada, Japan, Europe, and Rest of World Markets for Years
      2003, 2008 & 2012 (includes corresponding Graph/Chart)            II-80

      Table 35: World Recent Past, Current & Future Market Analysis
      for Other PD Drugs by Geographic Region - US, Canada, Japan,
      Europe, and Rest of World Independently Analyzed with Annual
      Sales Figures in US$ Million for Years 2000 through 2010
      (includes corresponding Graph/Chart)                              II-81

      Table 36: World Long-term Projections for Other PD Drugs by
      Geographic Region - US, Canada, Japan, Europe, and Rest of
      World Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2011 through 2015 (includes corresponding
      Graph/Chart)                                                      II-82

      Table 37: World 10-Year Perspective for Other PD Drugs by
      Geographic Region - Percentage Breakdown of Dollar Sales for
      US, Canada, Japan, Europe, and Rest of World Markets for Years
      2003, 2008 & 2012 (includes corresponding Graph/Chart)            II-83


III. MARKET

  1. The United States                                                  III-1
      A.Market Analysis                                                 III-1
        Current & Future Analysis                                       III-1
        AD Market Overview                                              III-1
         Approval of Cholinesterase Inhibitors for MCI to Drive Market  III-1
         Competitive Landscape                                          III-2
          Table 38: Leading Therapeutics in the North American
          Alzheimer's Disease Market (2005 & 2004): Percentage
          Breakdown by New Prescription for Aricept, Exelon,
          Namenda, and Razadyne (includes corresponding Graph/Chart)    III-2
         Status of AD Drugs                                             III-3
         New Products in Clinical Trails                                III-3
         Prevalence                                                     III-4
          Table 39: Alzheimer's Disease Prevalence in the US for
          Years 2005 through 2010 (includes corresponding
          Graph/Chart)                                                  III-4
        PD Therapies Market                                             III-4
         Levodopa/Carbidopa on Declining Spree                          III-4
         Competition                                                    III-4
          Table 40: Leading Brands in the US PD Therapeutics Market
          (2004-2006E): Percentage Breakdown by Prescription for
          Generic Amantadine, Generic Benzitropine, Generic
          Levodopa/Carbidopa, Comtan, Mirapex, Requip, Generic
          Selegiline, Sinemet/Sinemet CR, Rasagiline, and Others
          (includes corresponding Graph/Chart)                          III-5
         Patent Expiry Status                                           III-5
          Patent Expiry Status of Parkinson's Disease Drugs in the US   III-5
         New Brands and Pipeline Analysis                               III-6
         PD Prevalence                                                  III-6
        New Findings                                                    III-6
        Strategic Corporate Developments                                III-8
        Key Players                                                     III-15
      B.Market Analytics                                                III-18
        Table 41: US Recent Past, Current & Future Analysis for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine  Agonists, and Other PD
        Drugs) Markets Independently Analyzed with Annual Sales
        Figures in US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-18

        Table 42: US Long-term Projections for Anti-Alzheimer's and
        Anti-Parkinson's Disease Drugs by Product Segment -
        Anti-Alzheimer's Disease Drugs (Cholinesterase Inhibitors
        and NMDARA (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets Independently
        Analyzed with Annual Sales Figures in US$ Million for Years
        2011 through 2015 (includes corresponding Graph/Chart)          III-19

        Table 43: US 10-Year Perspective for Anti-Alzheimer's and
        Anti-Parkinson's Disease Drugs by Product Segment -
        Percentage Breakdown of Dollar Sales for Anti-Alzheimer's
        Disease Drugs (Cholinesterase Inhibitors and NMDARA
        (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets for 2003,
        2008 & 2012 (includes corresponding Graph/Chart)                III-20

  2. Canada                                                             III-21
      A.Market Analysis                                                 III-21
        Current & Future Analysis                                       III-21
        Prevalence                                                      III-21
        Strategic Corporate Developments                                III-21
      B.Market Analytics                                                III-22
        Table 44: Canadian Recent Past, Current & Future Analysis
        for Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-22

        Table 45: Canadian Long-term Projections for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2011 through 2015 (includes
        corresponding Graph/Chart)                                      III-23

        Table 46: Canadian 10-Year Perspective for Anti-Alzheimer's
        and Anti-Parkinson's Disease Drugs by Product Segment -
        Percentage Breakdown of Dollar Sales for Anti-Alzheimer's
        Disease Drugs (Cholinesterase Inhibitors and NMDARA
        (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets for 2003,
        2008 & 2012 (includes corresponding Graph/Chart)                III-24

  3. Japan                                                              III-25
      A.Market Analysis                                                 III-25
        Current & Future Analysis                                       III-25
        Prevalence                                                      III-25
        Strategic Corporate Developments                                III-25
      B.Market Analytics                                                III-26
        Table 47: Japanese Recent Past, Current & Future Analysis
        for Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic  Agents, Dopamine Agonists, and Other PD
        Drugs) Markets Independently Analyzed with Annual Sales
        Figures in US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-26

        Table 48: Japanese Long-term Projections for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2011 through 2015 (includes
        corresponding Graph/Chart)                                      III-27

        Table 49: Japanese 10-Year Perspective for Anti-Alzheimer's
        and Anti-Parkinson's Disease Drugs by Product Segment -
        Percentage Breakdown of Dollar Sales for Anti-Alzheimer's
        Disease Drugs (Cholinesterase Inhibitors and NMDARA
        (N-methyl, D-Aspartate Receptor Antagonists)), Anti
        Parkinson's Disease Drugs (Dopaminergic Agents, Dopamine
        Agonists, and Other PD Drugs) Markets for 2003, 2008 & 2012
        (includes corresponding Graph/Chart)                            III-28

  4. Europe                                                             III-29
      A.Market Analysis                                                 III-29
        Current & Future Analysis                                       III-29
        Prevalence                                                      III-29
         Alzheimer's Disease                                            III-29
          Table 50: European Alzheimer's Disease Prevalence For
          Years 2000 through 2010: Number of Patients (in '000) by
          Country/Region for Germany, France, UK, Italy, Spain, and
          Rest of Europe (includes corresponding Graph/Chart)           III-30
         Parkinson's Disease                                            III-30
          Table 51: European Parkinson's Disease Prevalence For
          Years 2000 through 2010: Number of Patients (in '000) by
          Country/Region for Germany, France, UK, Italy, Spain, and
          Rest of Europe (includes corresponding Graph/Chart)           III-30
        Competitive Scenario                                            III-31
         Table 52: Leading Brands in the European Alzheimer's
         Disease Market (2005): Percentage Breakdown by New
         Prescription for Aricept, Ebixa/Auxura, Exelon, and
         Razadyne (includes corresponding Graph/Chart)                  III-31
        Strategic Corporate Developments                                III-31
      B.Market Analytics                                                III-32
        Table 53: European Recent Past, Current & Future Analysis
        for Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Geographic Region - Germany, France, UK, Italy, Spain, and
        Rest of Europe Markets Independently Analyzed with Annual
        Sales Figures in US$ Million for Years 2000 through 2010
        (includes corresponding Graph/Chart)                            III-32

        Table 54: European Long-term Projections for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Geographic Region - Germany, France, UK, Italy, Spain, and
        Rest of Europe Markets Independently Analyzed with Annual
        Sales Figures in US$ Million for Years 2011 through 2015
        (includes corresponding Graph/Chart)                            III-33

        Table 55: European Recent Past, Current & Future Analysis
        for Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-34

        Table 56: European Long-term Projections for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2011 through 2015 (includes
        corresponding Graph/Chart)                                      III-35

        Table 57: Rest of Europe 10-Year Perspective for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Geographic Region - Percentage Breakdown of Dollar Sales for
        Germany, France, UK, Italy, Spain, and Rest of Europe
        Markets for 2003, 2008 & 2012 (includes corresponding
        Graph/Chart)                                                    III-36

        Table 58: Rest of Europe 10-Year Perspective for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Percentage Breakdown of Dollar Sales for
        Anti-Alzheimer's Disease Drugs (Cholinesterase Inhibitors
        and NMDARA (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets for 2003,
        2008 & 2012 (includes corresponding Graph/Chart)                III-37

  4a. Germany                                                           III-38
      A.Market Analysis                                                 III-38
        Current & Future Analysis                                       III-38
        Prevalence                                                      III-38
        Strategic Corporate Developments                                III-38
        Key Players                                                     III-39
      B.Market Analytics                                                III-40
        Table 59: German Recent Past, Current & Future Analysis for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-40

        Table 60: German Long-term Projections for Anti-Alzheimer's
        and Anti-Parkinson's Disease Drugs by Product Segment -
        Anti-Alzheimer's Disease Drugs (Cholinesterase Inhibitors
        and NMDARA (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets Independently
        Analyzed with Annual Sales Figures in US$ Million for Years
        2011 through 2015 (includes corresponding Graph/Chart)          III-41

        Table 61: German 10-Year Perspective for Anti- Alzheimer's
        and Anti-Parkinson's Disease Drugs by Product Segment -
        Percentage Breakdown of Dollar Sales for Anti-Alzheimer's
        Disease Drugs (Cholinesterase Inhibitors and NMDARA
        (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets for 2003,
        2008 & 2012 (includes corresponding Graph/Chart)                III-42

  4b. France                                                            III-43
      A.Market Analysis                                                 III-43
        Current & Future Analysis                                       III-43
        Prevalence                                                      III-43
      B.Market Analytics                                                III-44
        Table 62: French Recent Past, Current & Future Analysis for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti- Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-44

        Table 63: French Long-term Projections for Anti-Alzheimer's
        and Anti-Parkinson's Disease Drugs by Product Segment -
        Anti- Alzheimer's Disease Drugs (Cholinesterase Inhibitors
        and NMDARA (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets Independently
        Analyzed with Annual Sales Figures in US$ Million for Years
        2011 through 2015 (includes corresponding Graph/Chart)          III-45

        Table 64: French 10-Year Perspective for Anti- Alzheimer's
        and Anti-Parkinson's Disease Drugs by Product Segment -
        Percentage Breakdown of Dollar Sales for Anti-Alzheimer's
        Disease Drugs (Cholinesterase Inhibitors and NMDARA
        (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets for 2003,
        2008 & 2012 (includes corresponding Graph/Chart)                III-46

  4c. United Kingdom                                                    III-47
      A.Market Analysis                                                 III-47
        Current & Future Analysis                                       III-47
        Prevalence                                                      III-47
        New Findings                                                    III-47
        Strategic Corporate Developments                                III-48
        Key Players                                                     III-48
      B.Market Analytics                                                III-50
        Table 65: UK Recent Past, Current & Future Analysis for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti- Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-50

        Table 66: UK Long-term Projections for Anti-Alzheimer's and
        Anti-Parkinson's Disease Drugs by Product Segment - Anti-
        Alzheimer's Disease Drugs (Cholinesterase Inhibitors and
        NMDARA (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets Independently
        Analyzed with Annual Sales Figures in US$ Million for Years
        2011 through 2015 (includes corresponding Graph/Chart)          III-51

        Table 67: UK 10-Year Perspective for Anti-Alzheimer's and
        Anti-Parkinson's Disease Drugs by Product Segment -
        Percentage Breakdown of Dollar Sales for Anti-Alzheimer's
        Disease Drugs (Cholinesterase Inhibitors and NMDARA
        (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets for 2003,
        2008 & 2012 (includes corresponding Graph/Chart)                III-52

  4d. Italy                                                             III-53
      A.Market Analysis                                                 III-53
        Current & Future Analysis                                       III-53
        Prevalence                                                      III-53
        Strategic Corporate Developments                                III-53
      B.Market Analytics                                                III-54
        Table 68: Italian Recent Past, Current & Future Analysis for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-54

        Table 69: Italian Long-term Projections for Anti-Alzheimer's
        and Anti-Parkinson's Disease Drugsby Product Segment -
        Anti-Alzheimer's Disease Drugs (Cholinesterase Inhibitors
        and NMDARA (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets Independently
        Analyzed with Annual Sales Figures in US$ Million for Years
        2011 through 2015 (includes corresponding Graph/Chart)          III-55

        Table 70: Italian 10-Year Perspective for Anti-Alzheimer's
        and Anti-Parkinson's Disease Drugs by Product Segment -
        Percentage Breakdown of Dollar Sales for Anti-Alzheimer's
        Disease Drugs (Cholinesterase Inhibitors and NMDARA
        (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets for 2003,
        2008 & 2012 (includes corresponding Graph/Chart)                III-56

  4e. Spain                                                             III-57
      A.Market Analysis                                                 III-57
        Current & Future Analysis                                       III-57
        Prevalence                                                      III-57
      B.Market Analytics                                                III-58
        Table 71: Spanish Recent Past, Current & Future Analysis for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-58

        Table 72: Spanish Long-term Projections for Anti-Alzheimer's
        and Anti-Parkinson's Disease Drugs by Product Segment -
        Anti-Alzheimer's Disease Drugs (Cholinesterase Inhibitors
        and NMDARA (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets Independently
        Analyzed with Annual Sales Figures in US$ Million for Years
        2011 through 2015 (includes corresponding Graph/Chart)          III-59

        Table 73: Spanish 10-Year Perspective for Anti-Alzheimer's
        and Anti-Parkinson's Disease Drugs by Product Segment -
        Percentage Breakdown of Dollar Sales for Anti-Alzheimer's
        Disease Drugs (Cholinesterase Inhibitors and NMDARA
        (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets for 2003,
        2008 & 2012 (includes corresponding Graph/Chart)                III-60

  4f. Rest of Europe                                                    III-61
      A.Market Analysis                                                 III-61
        Current & Future Analysis                                       III-61
        Prevalence                                                      III-61
        New Findings                                                    III-61
        Strategic Corporate Developments                                III-61
        Key Players                                                     III-62
      B.Market Analytics                                                III-64
        Table 74: Rest of Europe Recent Past, Current & Future
        Analysis for Anti-Alzheimer's and Anti- Parkinson's Disease
        Drugs by Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-64

        Table 75: Rest of Europe Long-term Projections for
        Anti-Alzheimer's and Anti- Parkinson's Disease Drugs by
        Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2011 through 2015 (includes
        corresponding Graph/Chart)                                      III-65

        Table 76: Rest of Europe 10-Year Perspective for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Percentage Breakdown of Dollar Sales for
        Anti-Alzheimer's Disease Drugs (Cholinesterase Inhibitors
        and NMDARA (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets for 2003,
        2008 & 2012 (includes corresponding Graph/Chart)                III-66

  5. Rest of World                                                      III-67
      A.Market Analysis                                                 III-67
        Current & Future Analysis                                       III-67
        Prevalence                                                      III-67
        Strategic Corporate Developments                                III-67
      B.Market Analytics                                                III-69
        Table 77: Rest of World Recent Past, Current & Future
        Analysis for Anti-Alzheimer's and Anti-Parkinson's Disease
        Drugs by Product Segment - Anti-Alzheimer's Disease Drugs
        (Cholinesterase Inhibitors and NMDARA (N-methyl, D-Aspartate
        Receptor Antagonists)), Anti-Parkinson's Disease Drugs
        (Dopaminergic Agents, Dopamine Agonists, and Other PD Drugs)
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-69

        Table 78: Rest of World Long-term Projections for
        Anti-Alzheimer's & Anti-Parkinson's Disease Drugs by Product
        Segment - Anti-Alzheimer's Disease Drugs (Cholinesterase
        Inhibitors and NMDARA (N-methyl, D-Aspartate Receptor
        Antagonists)), Anti-Parkinson's Disease Drugs (Dopaminergic
        Agents, Dopamine Agonists, and Other PD Drugs) Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2011 through 2015 (includes corresponding
        Graph/Chart)                                                    III-70

        Table 79: Rest of World 10-Year Perspective for
        Anti-Alzheimer's and Anti-Parkinson's Disease Drugs by
        Product Segment - Percentage Breakdown of Dollar Sales for
        Anti-Alzheimer's Disease Drugs (Cholinesterase Inhibitors
        and NMDARA (N-methyl, D-Aspartate Receptor Antagonists)),
        Anti-Parkinson's Disease Drugs (Dopaminergic Agents,
        Dopamine Agonists, and Other PD Drugs) Markets for 2003,
        2008 & 2012 (includes corresponding Graph/Chart)                III-71


 IV. COMPETITIVE LANDSCAPE

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