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New PublicationsANTIDEPRESSANTS MCP-1383
A GLOBAL STRATEGIC BUSINESS REPORT
CONTENTS
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
II. EXECUTIVE SUMMARY
1. Industry Overview II-1
Market Highlights II-1
Current and Future Analysis II-1
Industry Dynamics and Changing Scenario II-2
Intense Competition in the Antidepressants Marketplace II-2
Global Antidepressants Market (2004): Major Products in the
Pipeline II-3
Table 1: Leading Brands in the Global Antidepressants Market
(2001 & 2002): Sales in US$ Million for Seroxat/Paxil,
Zoloft, Effexor, Cipramil/ Celexa, Wellbutrin, Prozac,
Remeron, Fluoxetine Par, Serzone, and Fluoxetine Barr
(include corresponding Graphs/Chart) II-4
Table 2: Leading Drugs in the Global Antidepressants Market
(2003): Sales in US$ Million for Seroxat, Zoloft, Effexor,
Cipramil/ Celexa, Wellbutrin, Cipralex/ Lexapro, Prozac,
and Remeron (include corresponding Graphs/Chart) II-5
SSRI/SNRI Brands in the Global Antidepressants Market (
2002-2006): Sales in US$ Million by Geographic Region for
Cipralex/Lexapro, Effexor, Cipramil/ Celexa, Paxil,
Zoloft, and Cymbalta II-6
SSRIs Garnering Major Share of the Market II-7
Table 3: Leading Brands in the Global SSRI Antidepressants
Market (2003): Percentage Breakdown of Value Sales for
Zoloft, Paxil and Paxil CR, Generic Fluoxetine, Celexa,
Lexapro, Prozac, Prozac Weekly, and Others (include
corresponding Graphs/Chart) II-7
Emerging Antidepressant Classes Pose Threat to SSRI II-8
Market Snapshots II-8
2. Market Trends & Issues II-9
New Drugs Making Way into the Market II-9
Prozac Patent Expiry Opens Door for Generic Versions II-9
Generic Antidepressants to Hit Market Soon II-9
TCA Antidepressants Still in Use II-10
Improved Marketing Spurs Growth II-10
Westerners Fight Depression Blues; Americans Top the List II-10
Antidepressants High in Demand but Fail to Satisfy Consumers II-10
No One is Immune: Not Even Animals! II-11
Patent Expiry Disturbs Antidepressants Producers II-11
Unlicensed Antidepressants Pose Danger to Youth Safety II-11
Global Antidepressants Market (2003): Regulations Governing
Select Antidepressants Use in Children II-12
Growing Safety Concerns - Antidepressants Under Fire II-12
The Debate Flares II-12
Are Antidepressants Totally Safe? A Moot but Important Question II-12
Manufacturers Vociferous in their Protests II-13
No Satisfactory Answers Yet - The Wait Grows Longer II-13
Global Antidepressants Market: Drug Regulation for Kids in
Britain and the United States II-13
3. Depression: A Mental Review II-14
What is depression? II-14
Symptoms of Depression II-14
Causes of Depression II-14
Types of Depression and Related Disorders II-15
Major Depressive Disorders (Major Depression) II-15
Dysthymic Disorder (Minor Depression) II-15
Bipolar Disorder II-15
Related Disorder Types II-15
Seasonal Affective Disorder II-16
Premenstrual Dysphoric Disorder (PMDD) II-16
Anxiety Disorders II-16
Obsessive Compulsive Disorder II-16
Generalized Anxiety Disorder II-16
Panic Disorder II-16
Treatment of Depression II-16
Options Available in Depression Treatment II-17
Psychotherapy or Psychiatric Consultation II-17
Pharmacotherapy II-17
Combination of Psychotherapy and Pharmacotherapy II-17
Herbal and Nutritional Treatment II-17
Exercise II-17
How Can Depression Treatment become More Effective? II-17
Global Antidepressants Market: Favorable Drugs Under
Specific Conditions II-18
Global Antidepressants Market: Unfavorable Drugs Under
Specific Conditions II-18
Treatment-Resistant Depression (TRD) II-19
Optimizing the Dosage II-19
Switching of Medications II-19
Combination therapy II-19
Augmentation Therapy II-19
Electroconvulsive Therapy II-19
Facts and Figures on Depression II-20
Table 4: Global Antidepressants Market (2004): Percentage
Breakdown of Prevalence Rate by Disorder Type - Depression,
Anxiety, Obsessive Compulsive Disorder, Sleep Disorder,
Panic Disorder, Phobias, and Others (include corresponding
Graphs/Chart) II-20
Depression Hits the Elderly Hard II-20
Men Vs Women - Who is More Depression Prone? II-21
Depression and Smoking - Interlinked to One Another II-22
4. Product Analysis II-23
What are Antidepressants? A Clear Understanding II-23
Global Antidepressants Market (2004): Select Brands and their
Manufacturers II-23
Application Areas II-23
Select Antidepressants and their Applications II-24
Types of Antidepressants II-24
Tricyclic Antidepressants (TCAs) II-25
Global Antidepressants Market: TCA Brands and Dosage Types
- Starting Dosage and Normal Dosage II-25
Global Antidepressants Market: TCAs and their Side Effects II-26
Monamine Oxidase Inhibitors (MAOIs) II-26
Global Antidepressants Market: MAOI Brands and Dosage Types
- Starting Dosage and Normal Dosage II-26
Side Effects of Different MAOIs - Tranylcypromine;
Isocarboxazid and Phenelzine II-27
Selective Serotonin Reuptake Inhibitors (SSRIs) II-27
Global Antidepressants Market: SSRIs Brands and Related
Dosage - Starting Dosage and Normal Dosage II-27
Pharmacology II-27
FDA Approval II-28
Fluoxetine (Proxac) II-28
Citalopram II-28
Fluvoxamine (Luvox) II-28
Paroxetine II-29
Sertraline (Zoloft) II-29
Escitalopram II-29
Side Effects II-29
Global Antidepressants Market: Different SSRI Drugs and
their Side Effects II-30
Applications II-30
Global Antidepressants Market: SSRIs' Off-Label
Application Areas and Medication II-30
New Generation Antidepressants II-31
Dopamine-Reuptake Blocking Compounds II-31
Bupropion II-31
Serotonin and Noradrenaline Reuptake Inhibitors II-31
Venlafaxine II-31
5HT2 Receptor Antagonist Properties II-32
Nefazodone II-32
Trazodone II-32
Noradrenergic Antagonist II-32
Mirtazapine II-32
Global Antidepressants Market: New Generation Drugs and
Dosage Types - Starting Dosage and Normal Dosage II-33
Global Antidepressants Market: New Generation
Antidepressants and their Side Effects II-33
Global Antidepressants Market: Major Drugs by Class -
SSRI, SNRI, MAOI, and NaSSA II-34
5. Antidepressants: An In-Depth Analysis II-35
Tracing the Line of History II-35
Antidepressants, a Mere Accidental Discovery II-35
Limited Choices and High Risk Rates II-35
Better Alternatives and Wider Choice - The New Mantra II-35
Global Antidepressants Market: Launch of Drug Types - TCAs,
MAOI, SSRI, and New Generation Variants by Original
Version, Secondary Version, and Generic Version II-36
Adverse Effects of Antidepressants and their Management II-37
Sedation II-37
Orthostatic Hypotension II-37
Insomnia II-37
Anticholinergic Effects II-38
Weight Gain/Loss II-38
Sexual Dysfunction II-38
Side Effects Associated with Overdose II-38
Choosing an Antidepressant II-39
Table 5: Global Antidepressants Market: Percentage Breakdown
of Volume Drug Consumption by Disorder Type - Depression,
Generalized Anxiety Disorder, Post Traumatic Stress Disorder,
Panic Disorder and Others (include corresponding
Graphs/Chart) II-39
Switching Antidepressants II-40
Do Antidepressants Treat Depression Completely? II-40
Are Antidepressants Addictive? II-41
Global Antidepressants Market: Withdrawal Symptoms by Drug
Types - TCAs and SSRIs II-41
Disorders and Antidepressants II-42
Bipolar Disorder II-42
Anxiety Disorder II-42
Panic Disorder II-42
Antidepressants Used for Treatment of Panic Disorders,
their Efficacy/Recommendations, and Side Effects II-43
A Note of Caution for Panic Patients Using Antidepressants II-43
Generalized Anxiety Disorder II-43
SNRI II-44
SSRI II-44
TCAs II-44
Antidepressants Used for Treatment of Anxiety Disorders II-44
Antidepressants: Causes For and Against II-45
Cause for Antidepressants: II-45
Antidepressants Effective in Curing Premenstrual Dysphoric
Disorder II-45
Antidepressants Offer Solution for Itching and Scratching II-46
Antidepressants Offer Hope for Autistic Children II-46
Antidepressants Minimize Hot Flushes and Night Sweats II-46
Antidepressants' Positive Effect on the Brain II-47
Longer Duration Antidepressants Treatment Prevents Relapse II-47
Antidepressants - A New Option for Sleep Apnea II-47
SSRI Antidepressants May Prove Helpful in Cancer Treatment II-48
Antidepressants Relaxes Tremors II-48
Lesser Fear of Breast Cancer with Antidepressants II-48
Antidepressants for Reducing Chronic Back Pain II-48
Causes Against Antidepressants II-48
Greater Heart at Risk with Antidepressants II-48
Antidepressants Dissipates Sexual Drive II-49
Hip Fractures Troubles Aged Patients II-49
Antidepressants can be a Deadly Prescription for Kids II-50
Dental Problems with Antidepressants II-50
Facts/Myths About Antidepressants II-50
Are Pregnant Women at Risk from Antidepressants? II-50
Is Breast Feeding Safe While on Antidepressants? II-51
Homeopathic Treatment Versus Antidepressants Treatment -
Which is Better? II-51
Recent Findings on Antidepressants II-52
6. Technological Developments II-53
Monitoring Technology Foresees Antidepressants Effect II-53
Vagus Nerve Stimulation - Device for Treating Depression II-53
Global Antidepressants Market: FDA Approvals (2002-2004) II-53
7. Product Introductions/Innovations II-54
GlaxoSmithKline Re-Introduces Paxil CR in US Market II-54
Ratiopharm Launches Ratio-Paroxetine in Canada II-54
Organon Introduces Zispin SolTab II-54
Apotex Releases Generic Version of Paxil II-54
GlaxoSmithKline Launches Paxil CR II-54
Lundbeck Launches Lexapro II-55
8. Recent Industry Activity II-56
Pfizer Acquires Esperion II-56
Organon in Marketing Agreement with STADA II-56
Andrx Signs Marketing Agreement with Impax and Teva II-56
GlaxoSmithKline Collaborates with NeuroSearch II-56
Lundbeck in Marketing Accord with Janssen-Cilag II-56
Lundbeck Allies with Abbott Laboratories II-57
Myriad Signs an Agreement with Abbott Laboratories II-57
Recordati Obtains Marketing Rights from H Lundbeck II-57
9. Focus on Select Global Players II-58
AstraZeneca Plc (UK) II-58
Bristol-Myers Squibb (USA) II-58
Eli Lilly and Co. (USA) II-58
Forest Laboratories (USA) II-59
GlaxoSmithKline Plc (UK) II-59
H. Lundbeck A/S (Denmark) II-60
Merck & Co. (USA) II-60
Novartis AG (Switzerland) II-60
Organon International, Inc. (USA) II-60
Pfizer, Inc. (USA) II-61
Solvay SA (Brussels) II-61
Wyeth Pharmaceuticals (USA) II-61
10. Global Market Perspective II-63
Table 6: World Recent Past, Current & Future Analysis for
Antidepressants by Geographic Region - USA, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), and Latin America
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2000 through 2010 (include
corresponding Graphs/Chart) II-63
Table 7: World 10-Year Perspective for Antidepressants by
Geographic Region - Percentage Breakdown of Dollar Sales for
USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
and Latin America Markets for Years 2000, 2005 & 2010
(include corresponding Graphs/Chart) II-64
III. MARKET
1. The United States III-1
A.Market Analysis III-1
Current and Future Analysis III-1
Market Overview III-1
Antidepressants Usage in the United States III-1
US Antidepressants Market: Drug Usage III-2
Competitive Scenario III-2
Table 8:Leading Players in the US Antidepressants Market
(2004 & 2005(E)): Percentage Breakdown of Value Sales for
Forest Labs, GlaxoSmithKline, Pfizer, Wyeth, Eli Lilly and
Others (include corresponding Graphs/Chart) III-2
Table 9: Leading Players in the US SSRI/SNRI Market (2004 &
2005(E)): Percentage Breakdown of Value Sales for Forest
Labs, Pfizer, Wyeth, GlaxoSmithKline, Eli Lilly and Others
(include corresponding Graphs/Chart) III-3
Trends and Issues III-3
Are Americans Getting Too Depressed? III-3
New Drugs Set to Conquer the Market III-4
Table 10: Leading SSRI/ SNRI Brands in the US
Antidepressants Market (2000-2005(E)): Percentage
Breakdown of Sales for Prozac, Paxil, Zoloft, Celexa,
Lexapro, Effexor and Others (include corresponding
Graphs/Chart) III-4
Table 11: US Antidepressants Market (2000-2003): Number of
SSRI/SNRI Prescriptions Dispensed in Millions (include
corresponding Graphs/Chart) III-5
Table 12: US Antidepressants Market (2000): Advertising
Expenditure in US$ Million on Select SSRIs - Celexa
(Citalopram), Prozac (Fluoxetine), Effexor XR
(Venlafaxine), Zoloft (Sertraline), Paxil (Paroxetine),
and Luvox (Fluvoxamine) (include corresponding
Graphs/Chart) III-5
Depression More Common Among Gays III-5
FDA Inspects Suicidal Tendencies in Kids on Antidepressants III-6
FDA Imposes "black-box" Warning III-6
Generic Drugs Pose Competition to Branded Drugs III-7
Table 13: Leading SSRI Brands in the US Antidepressants
Market (2001): Sales in US$ Million for Zoloft, Paxil,
Prozac & Sarafem, Celexa, and Luvox (include
corresponding Graphs/Chart) III-7
Depression Drugs Being Used for Symptoms Other Than
Depression III-7
US Antidepressants Market: Drugs Approved for Different
Indications III-8
Frequent Patent Expiries - A Cause of Concern for
Manufacturers III-8
Patent Expiry of Select Antidepressant Brands in the
United States III-8
Product Launches/Developments III-9
Strategic Corporate Developments III-10
Key Players III-10
Bristol-Myers Squibb III-10
Eli Lilly and Co. III-11
Forest Laboratories III-11
Merck & Co. III-11
Organon International, Inc. III-12
Pfizer, Inc. III-12
Wyeth Pharmaceuticals III-12
B.Market Analytics III-13
Table 14: US Recent Past, Current & Future Analysis for
Antidepressants by Product Segment - SSRI, New Generation,
TCA and MAOI Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (include
corresponding Graphs/Chart) III-13
Table 15: US 10-Year Perspective for Antidepressants by
Product Segment - Percentage Breakdown of Dollar Sales for
SSRI, New Generation, TCA and MAOI for Years 2000, 2005 &
2010 (include corresponding Graphs/Chart) III-14
2. Canada III-15
A.Market Analysis III-15
Current and Future Analysis III-15
Market Overview III-15
Increasing Use of Antidepressants among Canadian Women III-15
Antidepressants Market - A Recent Past Perspective III-15
Table 16: Canadian Antidepressants Market (2001):
Percentage Breakdown of Value Sales by Class - SSRI, TCAs,
MOAI, and Others (include corresponding Graphs/Chart) III-16
Generic Serzone Recalled from Canadian Market in 2003 III-16
Warning Against Antidepressants Use in Under- 18 Age Group III-16
Product Launch III-17
B.Market Analytics III-17
Table 17: Canadian Recent Past, Current & Future Analysis
for Antidepressants: Annual Sales Figures in US$ Million
for Years 2000 through 2010 (include corresponding
Graphs/Chart) III-17
3. Japan III-18
A.Market Analysis III-18
Current and Future Analysis III-18
Recent Past Perspective III-18
Table 18: CNS Market in Japan (2001): Sales in US$ Million
by Drug Class - Antidepressants, Antiulcerants, Cholesterol
Reducers, Broad Antibiotic, Antiarrhythmic,
Antihypertensive, Narcotic painkiller, Oral Diabetes, Oral
Antihistamine, and Antiseizure (include corresponding
Graphs/Chart) III-19
Competitive Scenario III-19
Table 19: Leading Brands in the Japanese Antidepressants
Market (2001 & 2002): Percentage Breakdown of Value Sales
for Paxil, Luvox, Depromel, Ludiomil, Toledomin,
Toledomin- Jansen, Anafranil, Tetramide, and Others
(include corresponding Graphs/Chart) III-20
A Historical Perspective III-20
Antidepressants Market in Japan - Major Drug Launches the
Period 1973-2000 III-21
B.Market Analytics III-22
Table 20: Japanese Recent Past, Current & Future Analysis
for Antidepressants: Annual Sales Figures in US$ Million
for Years 2000 through 2010 (include corresponding
Graphs/Chart) III-22
4. Europe III-23
A.Market Analysis III-23
Current and Future Analysis III-23
Market Overview III-23
Table 21: Leading Players in the European Antidepressants
Market (2004 & 2005(E)) - Percentage Breakdown of Value
Sales for GlaxoSmithKline, Eli Lilly, Lundbeck, Pfizer,
Wyeth and Others (include corresponding Graphs/Chart) III-24
Changes in European Patent Litigation III-24
Strategic Corporate Developments III-24
B.Market Analytics III-25
Table 22: European Recent Past, Current & Future Analysis
for Antidepressants by Geographic Region - France, Germany,
UK, Italy, Spain, and Rest of Europe Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (include corresponding Graphs/Chart) III-25
Table 23: European 10-Year Perspective for Antidepressants
by Geographic Region - Percentage Breakdown of Dollar Sales
for France, Germany, UK, Italy, Spain, and Rest of Europe
Markets for Years 2000, 2005 & 2010 (include corresponding
Graphs/Chart) III-26
4a. France III-27
Market Analysis III-27
Current and Future Analysis III-27
Table 24: French Recent Past, Current & Future Analysis for
Antidepressants: Annual Sales Figures in US$ Million for
Years 2000 through 2010 (include corresponding
Graphs/Chart) III-27
4b. Germany III-28
Market Analysis III-28
Current and Future Analysis III-28
Table 25: German Recent Past, Current & Future Analysis for
Antidepressants: Annual Sales Figures in US$ Million for
Years 2000 through 2010 (include corresponding
Graphs/Chart) III-28
4c. The United Kingdom III-29
A.Market Analysis III-29
Current and Future Analysis III-29
Market Overview III-29
A Recent Past Perspective III-29
UK Bans Antidepressant Use in Children (2003) III-29
Table 26: Antidepressants Market in the UK (1993-2000):
Number of Associated Deaths in England and Wales by Drug
Class - TCAs, MAOIs, SSRIs and Others (include
corresponding Graphs/Chart) III-30
Prescriptions and Expenditure Statistics III-30
Regional Analysis - Scotland III-30
Antidepressants, a Happy Pill for Sad Scots III-30
Key Players III-31
AstraZeneca III-31
GlaxoSmithKline III-31
B.Market Analytics III-32
Table 27: UK Recent Past, Current & Future Analysis for
Antidepressants: Annual Sales Figures in US$ Million for
Years 2000 through 2010 (include corresponding
Graphs/Chart) III-32
4d. Italy III-33
Market Analysis III-33
Current and Future Analysis III-33
Table 28: Italian Recent Past, Current & Future Analysis
for Antidepressants: Annual Sales Figures in US$ Million
for Years 2000 through 2010 (include corresponding
Graphs/Chart) III-33
4e. Spain III-34
Market Analysis III-34
Current and Future Analysis III-34
Table 29: Spanish Recent Past, Current & Future Analysis
for Antidepressants: Annual Sales Figures in US$ Million
for Years 2000 through 2010 (include corresponding
Graphs/Chart) III-34
4f. Rest of Europe III-35
A.Market Analysis III-35
Current and Future Analysis III-35
Focus on Select Regional Markets III-35
Denmark III-35
Danish People Display Greater Preference for Antidepressants III-35
Finland III-35
Antidepressants Consumption Increases Among Young Adults III-35
Key Players III-35
H. Lundbeck A/S (Denmark) III-35
Novartis AG (Switzerland) III-36
Solvay SA (Brussels) III-36
B.Market Analytics III-36
Table 30: Rest of Europe Recent Past, Current & Future
Analysis for Antidepressants: Annual Sales Figures in US$
Million for Years 2000 through 2010 III-34 (include
corresponding Graphs/Chart) III-36
5. Asia-Pacific III-37
A.Market Analysis III-37
Current and Future Analysis III-37
Australia III-37
A Recent Past Market Perspective III-37
Commonly Used Antidepressants in Australia (2001) III-37
Strategic Corporate Development III-38
B.Market Analytics III-38
Table 31: Asia-Pacific Recent Past, Current & Future
Analysis for Antidepressants: Annual Sales Figures in US$
Million for Years 2000 through 2010 (include corresponding
Graphs/Chart) III-38
6. Latin America III-39
A.Market Analysis III-39
Current and Future Analysis III-39
Chile III-39
High Usage of Antidepressants among Chileans III-39
Strategic Corporate Development III-39
B.Market Analytics III-40
Table 32: Latin America Recent Past, Current & Future
Analysis for Antidepressants: Annual Sales Figures in US$
Million for Years 2000 through 2010 (include corresponding
Graphs/Chart) III-40
IV. COMPETITIVE LANDSCAPE
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