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Biotechnology Research Review

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Price:
USD $850.00
ISBN/SKU #:
GB-BIO069A
Research Group:
BCC
Date of Publication:
July 2009
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Summary

The global economic downturn that began in 2008 has slowed growth in nearly all technology sectors, including biotechnology markets. Nonetheless, the high value that biotechnology products can deliver, and the long-term growth potential of the sector will surely result in increased capital input and long-term sustained growth when the global economy recovers.
 
This research reprort provides comprehensive coverage of biotechnology markets for many years, and we are now increasing our production of biotechnology market research reports. This review of biotechnology market research conducted in 2008 and the first half of 2009 is meant to provide a sampling of the type of quantitative market information, analysis and guidance that has been aiding business decision-making.
 
This review includes highlights of reports on the following biotechnology markets:

  • Synthetic Biology

  • Commercial Amino Acids

  • Monoclonal Therapeutics and Companion Diagnostic Products

  • Environmental Markets for Biotechnology

  • Protein Drugs

  • Botanical and Plant-derived Drugs

  • Stem Cells

  • RNA Interference

  • DNA Diagnostics

  • Biologic Imaging Reagents


TABLE OF CONTENTS

Chapter- 1: INTRODUCTION -- Complimentary


Chapter-2: SYNTHETIC BIOLOGY: EMERGING GLOBAL MARKETS (BIO066A)

INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
INTENDED AUDIENCE
SCOPE OF REPORT
METHODOLOGY
INFORMATION SOURCES
RELATED BCC REPORTS
ANALYST CREDENTIALS
SUMMARY
TABLE 1 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET BY INDUSTRY, THROUGH 2013 ($ MILLIONS)
FIGURE 1 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET BY INDUSTRY, 2006-2013 ($ MILLIONS)
OVERVIEW
SYNTHETIC BIOLOGY TECHNOLOGIES COVERED IN THIS REPORT
TABLE 2 SCOPE OF THIS REPORT
WHAT IS SYNTHETIC BIOLOGY?
DEVELOPMENT STAGE OF SYNTHETIC BIOLOGY
FORCES DRIVING SYNTHETIC BIOLOGY MARKET GROWTH
TABLE 3 SYNTHETIC BIOLOGY GROWTH DRIVING FORCES
GLOBAL MARKET POTENTIAL FOR SYNTHETIC BIOLOGY PRODUCTS
TABLE 4 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET BY END USER, THROUGH 2013 ($ MILLIONS)
TABLE 5 GLOBAL VALUE OF SYNTHETIC BIOLOGY-ENABLED ENERGY MARKET BY FUEL TYPE, THROUGH 2013 ($ MILLIONS)
LIFE CYCLE STATUS OF SYNTHETIC BIOLOGY TECHNOLOGIES
TABLE 6 SYNTHETIC BIOLOGY PRODUCTS AND TECHNOLOGY LIFE CYCLE STAGE
THE SYNTHETIC BIOLOGY INDUSTRY
TABLE 7 SYNTHETIC BIOLOGY KEY COMPETITORS BY MARKET FOCUS


Chapter-3: COMMERCIAL AMINO ACIDS (BIO007H)

INTRODUCTION
STUDY OBJECTIVES
REASONS FOR DOING THIS STUDY
INTENDED AUDIENCE
SCOPE OF REPORT
INFORMATION SOURCES
ANALYST CREDENTIALS
RELATED BCC REPORTS
BCC ON-LINE SERVICES
DISCLAIMER
SUMMARY
TABLE 8 U.S. AMINO ACIDS MARKET SIZE, THROUGH 2013 ($ MILLIONS)
FIGURE 2 U.S. AMINO ACIDS MARKET SIZE, 2005-2013 ($ MILLIONS)
OVERVIEW OF AMINO ACIDS
TABLE 9 THE PROTEIN AMINO ACIDS
COMMERCIAL INTERESTS
TABLE 10 MAJOR COMMERCIAL APPLICATIONS
Feed Fortification
Food Flavoring Agents
Specialty Uses
Dietary Needs
TABLE 11 THE “ESSENTIAL” AMINO ACIDS
BIOLOGIC VALUE OF AMINO ACID MIXTURES
TABLE 12 PROTEIN VALUE OF SELECTED FOODS
RECOMMENDED DAILY ALLOWANCE
Amino Acid Metabolism
PROPERTIES
CHEMICAL STRUCTURE
TABLE 13 CHEMICAL STRUCTURE OF AMINO ACIDS
ISOLATION/ANALYSIS
Microbiological Assay
Chromatographic Separation
PRODUCTION TECHNOLOGY
TABLE 14 AMINO ACIDS BY PRODUCTION METHODS
Extraction
Fermentation
Microbiological Processes
TABLE 15 AMINO ACID PRODUCTION BY FERMENTATION
Chemical Synthesis
Enzymatic Conversion
REGULATION
Federal Drug Administration (FDA)
U.S. Pharmacopoeia (U.S.P)
TABLE 16 U.S.P VERIFIED AMINO ACID PRODUCTS
The Bush Administration
STRUCTURE OF THE INDUSTRY AND ITS COMPETITIVE ASPECTS
TABLE 17 MAJOR AMINO ACID PRODUCERS
FIGURE 3 SHARE OF GLOBAL AMINO ACIDS MARKET, 2008 (%)
IMPORTANT STRATEGIES
MARKET SHARE
TABLE 18 LEADING PRODUCERS, BY TYPE, OF AMINO ACID
FIGURE 4 MARKET SHARE OF MAJOR PLAYERS, 2008 (%)
MARKET FORCES


Chapter-4: MONOCLONAL THERAPEUTICS AND COMPANION DIAGNOSTIC PRODUCTS (BIO016G)

INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THIS STUDY
SCOPE OF REPORT
INTENDED AUDIENCE
METHODOLOGY
INFORMATION SOURCES
ABOUT THE AUTHOR
RELATED BCC WORK CREDENTIALS
EXECUTIVE SUMMARY
TABLE 19 WORLDWIDE SALES OF MONOCLONAL THERAPEUTIC AND COMPANION DIAGNOSTICS, THROUGH 2012 ($ BILLIONS)
FIGURE 5 WORLDWIDE SALES OF MONOCLONAL THERAPEUTIC AND COMPANION DIAGNOSTICS, 2005-2012 ($ BILLIONS)
MAB GROWTH IN THERAPEUTICS
Pharma Moves In
MAB GROWTH IN DIAGNOSTICS
Key Drivers and Challenges
Significant Trends
OVERVIEW
TABLE 20 BIOPHARMACEUTICAL CATEGORIES
TABLE 21   MONOCLONAL ANTIBODIES APPROVED FOR DISEASE THERAPY*
FIGURE 6 COMPOSITION OF COMMERCIALIZED ANTIBODIES BY TYPE, 2007 AND 2012 (%)
FIGURE 7 ANTIBODY ILLUSTRATED
MAB TECHNOLOGY: BEGINNINGS AND MOVEMENTS
TABLE 22   TIMELINE FOR MAB DEVELOPMENT
Moving Towards Humanization
ANTIBODY TECHNOLOGY TYPES
Humanization
TABLE 23 WORLDWIDE FORECAST OF THERAPEUTIC MONOCLONAL ANTIBODIES, BY TYPE, THROUGH 2012 ($ BILLIONS)
Superhumanization
Smart Technology
TABLE 24 SMART TECHNOLOGY ROYALTIES BY LICENSEE AND PRODUCT AS A PERCENTAGE OF TOTAL ROYALTY REVENUE:   EXAMPLE OF TECHNOLOGY ROYALTY POTENTIAL (%)
Fully Human Technology
Phage Display
Crucell’s Per.C6 and Mabstract
Transgenic Mice
TABLE 25   TRANSGENIC TECHNOLOGIES
Emerging Antibody Technology Types
Fragments
Single Chain Antibodies
Bispecific Antibodies
Conjugation
TABLE 26 LEADING CONJUGATION TECHNOLOGIES
TECHNOLOGY RELATED ISSUES AND CHALLENGES
Optimization
Adjusting Glycosylation
TABLE 27   ANTIBODY TECHNOLOGY BEHIND COMMERCIALIZED MABS
MANUFACTURING
LEGALITY AND INTELLECTUAL PROPERTY
Legality and Intellectual Property (Continued)
TABLE 28 CAT’S PHAGE AND RIBOSOME DISPLAY PATENTS
PHARMACEUTICAL AND BIOTECHNOLOGY LANDSCAPE
TABLE 29   PHARMA’S MAB-RELATED ACQUISITIONS
FIGURE 8   THE SYNERGY OF PHARMA AND BIOTECH
TABLE 30   GLOBAL SNAPSHOT: BIOTECHNOLOGY INDUSTRY, 2006


Chapter-5: ENVIRONMENTAL MARKETS FOR BIOTECHNOLOGY (BIO019B)

INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR STUDY AND IMPORTANCE
INTENDED AUDIENCE
SCOPE OF REPORT
INFORMATION SOURCES
ANALYST CREDENTIALS
RELATED REPORTS
SUMMARY
TABLE 31 U.S. VALUE OF ENVIRONMENTAL BIOTECHNOLOGY PRODUCTS FOR WASTE TREATMENT, THROUGH 2013 ($ MILLIONS)
FIGURE 9 MARKET SHARE BY PRODUCT TYPE, 2008 (%)


Chapter-6: PROTEIN DRUGS: GLOBAL MARKETS AND MANUFACTURING TECHNOLOGIES (BIO021C)

INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
SCOPE OF REPORT
INTENDED AUDIENCE
INFORMATION SOURCES
ANALYST CREDENTIALS
RELATED REPORTS
SUMMARY
TABLE 32 GLOBAL MARKET FOR PROTEIN THERAPEUTICS, THROUGH 2013 ($ MILLIONS)
FIGURE 10 GLOBAL MARKET FOR PROTEIN THERAPEUTICS, 2007-2013 ($ MILLIONS)


Chapter-7: BOTANICAL AND PLANT-DERIVED DRUGS: GLOBAL MARKETS (BIO022E)

INTRODUCTION
STUDY BACKGROUND
STUDY GOAL AND OBJECTIVES
INTENDED AUDIENCE
SCOPE OF REPORT
METHODOLOGY AND INFORMATION SOURCES
COMMERCIAL DRUGS
DEVELOPMENTAL DRUGS
TABLE 33 FDA APPROVAL PROCESS FOR NEW DRUGS
ANALYST CREDENTIALS
RELATED BCC PUBLICATIONS
SUMMARY
TABLE 34 GLOBAL FORECAST FOR BOTANICAL* AND PLANT-DERIVED DRUGS, THROUGH 2013 ($ BILLIONS)
FIGURE 11 GLOBAL FORECAST FOR BOTANICAL* AND PLANT-DERIVED DRUGS, 2006-2013 ($ BILLIONS)
OVERVIEW
BRIEF HISTORY OF PLANT-DERIVED MEDICINES
TABLE 35 KEY DATES IN BOTANICAL MEDICINE
TABLE 36 WELL KNOWN PLANT-DERIVED DRUGS
OPPORTUNITY LIES BEYOND WHAT’S KNOWN
FIGURE 12 COMPOSITION OF FDA-APPROVED NATURAL-DERIVED COMPOUNDS IN U.S. (2000–2005)* (%)
KEY DRIVERS
KEY CHALLENGES
SIGNS OF INDUSTRY INVESTMENT
TABLE 37 SWOT ANALYSIS ON BOTANICAL DRUG DEVELOPMENT
TABLE 38 KEY SIGNS OF INVESTMENT IN BOTANICAL AND OTHER PLANT-DERIVED DRUGS
BOTANICAL DRUGS DEFINED
UNDERSTANDING THE REGULATORY PROCESS
TABLE 39 DISTINCTIONS AMONG PRODUCTS THAT USE PLANTS MEDICINALLY
THE FIRST APPROVED BOTANICAL
A GROWING PIPELINE
FIGURE 13 INDS IN THE FDA BY THERAPEUTIC AREA (NUMBER)
OVERALL PHARMA LANDSCAPE
TABLE 40 TOP PHARMA COMPANIES BY REVENUE, 2007 ($ BILLIONS)
MAJOR CLASSES OF PLANT DRUGS
Terpenes and Steroids
Terpenes
Steroids
Alkaloids and Glycosides
Alkaloids
•Ergot Alkaloids
•Morphine Alkaloids
•Vinca Alkaloids
Glycosides
•Cardiac Glycosides
•Anthraglycosides
Phenols
E. Cava Algae
Flavonoids
•Resveratrol
Coumarin
Catechins
Proanthocyanidins
INTELLECTUAL PROPERTY
PRODUCTION
MOVING PRODUCTION FORWARD
ARTEMISININ: A CASE STUDY
SUPPLY AND LEGAL ISSUES
TABLE 41 MAJOR PRODUCERS OF RAW MATERIALS FOR PLANT-BASED MEDICINALS
DRUG DEVELOPMENT AND MANUFACTURE
TABLE 42 KEY COMPANIES WITH NATURAL PRODUCT LIBRARIES


Chapter-8: STEM CELL TECHNOLOGY: CURRENT APPLICATIONS AND FUTURE DIRECTIONS (BIO035C)

INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
SCOPE OF REPORT
INTENDED AUDIENCE
INFORMATION SOURCES
ANALYST CREDENTIALS
RELATED BCC REPORTS
SUMMARY
TABLE 43 U.S. MARKET FOR STEM CELLS IN REGENERATIVE MEDICINE REVENUE, THROUGH 2012 ($ MILLIONS)
FIGURE 14 U.S. MARKET FOR STEM CELLS IN REGENERATIVE MEDICINE REVENUE, 2005-2012 ($ MILLIONS)
INTRODUCTION TO STEM CELLS TECHNOLOGY IN REGENERATIVE MEDICINE MARKET
STEM CELLS IN CELLULAR THERAPEUTICS
FIGURE 15 FLOW DIAGRAM OF PROCESS USING STEM CELLS IN CELLULAR THERAPEUTICS
TABLE 44 PROJECTED U.S. GROWTH TREND FOR STEM CELLS IN CELL-BASED THERAPEUTICS FOR HUMAN ADULT AND EMBRYONIC STEM CELLS, THROUGH 2012 ($ MILLIONS)
FIGURE 16 PROJECTED U.S. GROWTH TREND FOR STEM CELLS IN CELL-BASED THERAPEUTICS FOR HUMAN ADULT AND EMBRYONIC STEM CELLS, 2005-2012 ($ MILLIONS)
Stem Cells in Cellular Therapeutics towards Engineering Tissue in Vitro for Transplantation
FIGURE 17 FLOW DIAGRAM OF PROCESS USING STEM CELLS IN ENGINEERING TISSUE FOR TRANSPLANTATION
THERAPEUTIC STEM CELL BANKING
FIGURE 18 FLOW DIAGRAM FOR PROCESS OF THERAPEUTIC BANKING OF STEM CELLS
TABLE 45 PROJECTED U.S. GROWTH TREND FOR THERAPEUTIC STEM CELL BANKING, THROUGH 2012 ($ MILLIONS)
FIGURE 19 PROJECTED U.S. GROWTH TREND FOR THERAPEUTIC STEM CELL BANKING, 2005-2012 ($ MILLIONS)


Chapter-9: RNA INTERFERENCE IN THE POST-GENOMIC ERA: MARKETS AND TECHNOLOGIES

INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
INTENDED AUDIENCE
SCOPE OF REPORT
METHODOLOGY
INFORMATION SOURCES
RELATED BCC REPORTS
ANALYST CREDENTIALS
SUMMARY
TABLE 46 GLOBAL VALUE OF RNA INTERFERENCE MARKET BY MARKET SEGMENT, THROUGH 2013 ($ MILLIONS)
FIGURE 20 GLOBAL VALUE OF RNA INTERFERENCE MARKET BY MARKET SEGMENT, 2006-2013 ($ MILLIONS)
OVERVIEW
INTRODUCTION
CONVERGENCE OF POST GENOME TECHNOLOGIES
TABLE 47 POST GENOME ENABLING TOOLS
TABLE 48 NEW PARADIGM OF RNA INTERFERENCE
MARKET POTENTIAL OF RNA INTERFERENCE-BASED PRODUCTS
GLOBAL RNAI MARKET FORECAST
TABLE 49 GLOBAL VALUE OF RNA INTERFERENCE MARKET BY MARKET SEGMENT, THROUGH 2013 ($ MILLIONS)
GLOBAL RNAI RESEARCH TOOLS MARKET
TABLE 50 GLOBAL VALUE OF RNA INTERFERENCE RESEARCH TOOLS MARKET BY PRODUCT TYPE, THROUGH 2013 ($ MILLIONS)
TABLE 51 GLOBAL VALUE OF RNA INTERFERENCE DRUG MARKET, BY CLASS, THROUGH 2013 ($ MILLIONS)
GROWTH DRIVING FORCES IN RNA INTERFERENCE MARKETS
TABLE 52 PRIMARY FORCES DRIVING RNA INTERFERENCE GROWTH
RNA INTERFERENCE: BUILDING ON ANTISENSE TECHNOLOGIES
TABLE 53 KEY ANTISENSE CONTRIBUTIONS TO RNA INTERFERENCE
APPLICATIONS OF RNA INTERFERENCE
RNA INTERFERENCE AS A GENE KNOCKDOWN TECHNOLOGY
RNA INTERFERENCE AS A BIOMARKER
RNA INTERFERENCE IN THERAPEUTICS
RNA INTERFERENCE IN AGRICULTURE
THE RNA INTERFERENCE INDUSTRY
RNA INTERFERENCE TECHNOLOGIES
INTRODUCTION
ROLE OF MESSENGER RNA IN PROTEIN PRODUCTION
FIGURE 21 ROLE OF MESSENGER RNA IN PROTEIN PRODUCTION
TABLE 54 BASIC STEPS IN PROTEIN PRODUCTION


Chapter-10: DNA DIAGNOSTICS: TECHNOLOGIES AND GLOBAL MARKETS (BIO063A)

INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
SCOPE OF REPORT
INTENDED AUDIENCE
METHODOLOGY AND INFORMATION SOURCES
ANALYST CREDENTIALS
RELATED BCC REPORTS
SUMMARY
TABLE 55 GLOBAL MARKET FOR CLINICAL DNA DIAGNOSTICS, BY SEGMENT, THROUGH 2013 ($ MILLIONS)
FIGURE 22 GLOBAL MARKET FOR CLINICAL DNA DIAGNOSTICS, BY SEGMENT, 2005-2013 ($ MILLIONS)
OVERVIEW
INTRODUCTION TO GENOMIC DIAGNOSTICS
EXPRESSION PROFILING AND DISEASE
EXPRESSION PROFILING AND INFECTIOUS DISEASE
DNA SEQUENCING FOR GENOTYPING AND DIAGNOSIS
CLINICAL PHARMACOLOGY
MUTATION DETECTION AND GENOTYPING FOR SPECIFIC GENES
IDENTIFICATION OF NEW DISEASE GENES
REGULATORY FACTORS
SUCCESSES AND LIMITATIONS OF GENETIC TESTING
REGULATORY POLICIES
FOOD AND DRUG ADMINISTRATION: NEW GUIDELINES
INTERNAL STANDARDS FOR DNA DIAGNOSTICS
INSURANCE
MARKETING DIRECTLY TO CONSUMERS
MARKET FOR CLINICAL DNA DIAGNOSTICS, BY PRODUCT
TABLE 56 GLOBAL MARKET FORECAST FOR DNA DIAGNOSTICS PRODUCTS, THROUGH 2013 ($ MILLIONS)
FIGURE 23 GLOBAL MARKET FORECAST FOR DNA DIAGNOSTICS PRODUCTS, 2005-2013 ($ MILLIONS)
FIGURE 24 GLOBAL DNA DIAGNOSTICS MARKET, BY PRODUCT SHARE, 2008 (%)
FIGURE 25 GLOBAL DNA DIAGNOSTICS MARKET, BY PRODUCT SHARE, 2013 (%)


Chapter-11: BIOLOGIC IMAGING REAGENTS: TECHNOLOGIES AND GLOBAL MARKETS (BIO064A).

INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
INTENDED AUDIENCE
SCOPE OF REPORT
METHODOLOGY
INFORMATION SOURCES
RELATED BCC REPORTS
ANALYST CREDENTIALS
SUMMARY
TABLE 57 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY TYPE, THROUGH 2013 ($ MILLIONS)
FIGURE 26 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY TYPE, 2006-2013 ($ MILLIONS)
OVERVIEW
INTRODUCTION
BIOLOGIC IMAGING TECHNOLOGIES COVERED IN THIS REPORT
TABLE 58   SCOPE OF THIS REPORT
MARKET POTENTIAL OF BIOLOGIC REAGENTS PRODUCTS
TABLE 59 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY TECHNOLOGY, THROUGH 2013 ($ MILLIONS)
TABLE 60 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY END USER MARKET, THROUGH 2013 ($ MILLIONS)
FORCES DRIVING BIOLOGIC IMAGING REAGENTS INDUSTRY GROWTH
TABLE 61 BIOLOGIC IMAGING REAGENTS GROWTH DRIVING FORCES
LIFE CYCLE STATUS OF BIOLOGIC IMAGING REAGENTS TECHNOLOGIES
TABLE 62 LIFE CYCLE STAGE OF BIOLOGIC IMAGING REAGENTS
THE BIOLOGIC IMAGING REAGENTS INDUSTRY
TABLE 63 BIOLOGIC IMAGING REAGENTS KEY COMPETITORS

 

 

 

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