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New PublicationsBULK PACLITAXEL MCP-1208
A GLOBAL STRATEGIC BUSINESS REPORT
CONTENTS
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-2
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
II. EXECUTIVE SUMMARY
1. Industry Overview II-1
Paclitaxel - Leading from the Front II-1
US Market - Magnificently Outdistancing Others II-1
Cancer Blockbusters - Facing the Brunt II-1
A Sunrise Opportunity II-1
BMS' Reign Comes to an End II-2
Exploring New Avenues II-2
Falling Prices - Boon for The Customers, Bane for The Companies II-2
All the Strangle for Peanuts? II-3
Factors Affecting the Market II-3
Paclitaxel Versus Abraxane II-3
2. Outlook II-5
Bulk Paclitaxel - Great Future Ahead II-5
Competitive Scenario II-5
Cancer Generics - A Time for Optimism II-5
The US Piazza II-6
3. Product Overview II-7
Chemical Properties II-7
Sourcing II-7
From Natural Sources II-8
Yew Trees II-8
From Semi-Synthesis Process II-8
Mechanism of Action II-8
History of Paclitaxel and its Discovery as an Anti-Cancer Agent II-9
China Wins Laurels for Supply of Natural Paclitaxel II-10
Hazelnut Trees Emerge as the Alternate Source of Paclitaxel II-10
Taxol - The Uncrowned Leader II-11
Paclitaxel - Concerns II-11
Abraxane and Tocosol: Set to Ride the Market Duel? II-11
Many Faces (Phases) of Paclitaxel - The Variants II-12
Taxotere - A Potential Competitor to Paclitaxel II-12
4. Research and Development II-13
Angiotech Unfurls New Dimensions for Paclitaxel II-13
Clinical Research Favors Paclitaxel for Breast Cancer Treatment II-13
American BioScience' Nab Technology Unveils Higher Tissue
Penetration Potential II-13
Naturol Develops Unique Extraction Technology for Producing
Paclitaxel from Canadian Yew II-14
Ivax Corp.'s Xorane Revolutionizes the Delivery of Paclitaxel II-14
5. Product Launches/Introductions II-15
Dabur Launches Cancer Drug. II-15
Dabur Introduces Nanoxel. II-15
Nippon Introduces Paclitaxel Injection NK. II-15
6. Recent Industry Activity II-16
Sonus to Merge with OncoGenex II-16
Acusphere Signs Licensing Deal with Cephalon II-16
Sonus Terminates TOCOSOL Paclitaxel Development Program II-16
Eagle Pharmaceuticals to Develop and Market Tocosol Paclitaxel II-16
Pliva Lachema Receives ANDA for Paclitaxel Injection II-16
Cell Therapeutics Receives EMEA Acceptance II-17
Abraxis Wins Approval for ABRAXANE in Korea II-17
Boston Scientific Obtains Approval for TAXUS Liberte from
Health Canada . II-17
Cell Therapeutics Renames Xyotax as Opaxio II-17
Hospira Takes Over Mayne Pharma II-17
Protherics to Acquire MacroMed II-17
Abraxis Acquires Arizona Production Facility II-18
Indena Inks Worldwide License Agreement with Spectrum Pharma II-18
Bioxel Bags Major Paclitaxel Order II-18
Bioxel Enters into Supply Agreement II-18
Bioxel Bags Paclitaxel Supply Contract II-19
Indena Establishes New Plant to Produce Synthetic Paclitaxel II-19
Abraxis Selects Korean Green Cross to Market ABRAXANE II-19
Abraxis Grants License to Biocon for Marketing ABRAXANE II-19
Bioxel Registers Docetaxel with US FDA II-19
Bayer Quashes TOCOSOL Paclitaxel License with Sonus II-20
Abraxis' ABRAXANE Convinces European CHMP II-20
Abraxis Receives Approval for ABRAXANE in Australia II-20
Eurocor Receives CE Mark II-20
SuperGen Divests Certain Drugs to Intas II-20
Abraxis Plans Separation of Oncology Business II-20
Teva Acquires IVAX II-21
Mayne to Acquire Nipent and SurfaceSafe Product Rights in
North America II-21
Athersys Expands Research Collaboration with Bristol-Myers
Squibb II-21
American Pharmaceutical Partners and American BioScience
Combine to Create Abraxis BioScience II-22
Bioxel Increases its Presence in Europe II-22
Xechem Resolves Paclitaxel Antitrust Lawsuit with Bristol-
Myers Squibb II-22
Angiotech Acquires American Medical Instruments II-22
Paxis Signs Supply Agreement for Europe and the United States II-22
Angiotech to Take Over Quill Medical II-22
Bioxel and Cook Enters Supply Agreement for Paclitaxel II-23
Angiotech Acquires Lifespan Vascular Graft Business II-23
Bristol-Myers Extends Agreement with Ambit II-23
Angiotech Takes Over Afmedica II-23
Bristol-Myers Squibb Gets European Approval for Paclitaxel II-23
Angiotech Signs Exclusive License Agreement with CABG Medical II-24
Conor Medsystems Acquires the Assets of Phytogen Life Sciences II-24
Sonus Pharmaceuticals and Schering Sign Licensing Agreement. II-24
Sonus' Tocosol Wins FDA's ODD II-24
ABI's Abraxane Wins FDA Approval II-25
SuperGen's Paclitaxel Injection Accorded ANDA Status from the
USFDA II-25
Ivax Signs Agreement with Mayne II-25
Integrated Bio Pharma Acquires Hauser CRO II-25
Mayne Gearing up to Fight it Alone with Proprietary Paclitaxel II-25
Bioxel Inks a Paclitaxel Supply Deal with CTI II-25
DFB Pharmaceuticals Takes Over Phyton II-25
NaPro Divests Paclitaxel Business to Faulding II-26
Bioxel-Aerojet's Large-Scale Paclitaxel Purification Process
Gets FDA's Nod II-26
Ivax Earns Expanded Approval for Paxene from the European
Commission II-26
Sonus Obtains Third Patent for the Composition of Tocosol
Paclitaxel II-26
Bioxel Forays into the European Market II-26
Xechem Pockets Additional Patents for Second Generation
Paclitaxel II-27
Dabur Pharma Initiates Phase IIb Trial for Nanoparticle
Delivery Systems II-27
Acusphere Inc. Completes Phase 1 Trial for AI-850 II-27
Tisorex Changes Name to Paxis Pharmaceuticals II-27
7. Focus on Select Global Players II-28
Abraxis BioScience, Inc. (USA) II-28
Bioxel Pharma Inc. (Canada) II-28
Bristol-Myers Squibb Co. (USA) II-28
Hospira, Inc. (USA) . II-28
Indena S.p.A. (Italy) II-29
OncoGenex Pharmaceuticals, Inc. (USA). II-29
Teva Pharmaceuticals USA, Inc. (USA) . II-29
Xechem International Inc. (USA) II-30
8. Global Market Perspective II-31
Table 1: World Recent Past, Current & Future Analysis for
Bulk Paclitaxel by Geographic Region - US and Rest of World
Markets Independently Analyzed with Annual Sales in Kilograms
for Years 2000 through 2010 (includes corresponding
Graph/Chart) II-31
Table 2: World Long-term Projections for Bulk Paclitaxel by
Geographic Region - US and Rest of World Markets Independently
Analyzed with Annual Sales in Kilograms for Years 2011 through
2015 (includes corresponding Graph/Chart) II-32
Table 3: World Recent Past, Current & Future Analysis for Bulk
Paclitaxel by Geographic Region - US and Rest of World Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2000 through 2010 (includes corresponding Graph/Chart) II-33
Table 4: World Long-term Projections for Bulk Paclitaxel by
Geographic Region - US and Rest of World Markets Independently
Analyzed with Annual Sales in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) II-34
Table 5: World 10-Year Perspective for Bulk Paclitaxel by
Geographic Region - Percentage Breakdown by Volume Sales for
US and Rest of World Markets for Years 2003, 2008, & 2012 II-35
Table 6: World 10-Year Perspective for Bulk Paclitaxel by
Geographic Region - Percentage Breakdown by Dollar Sales for
US and Rest of World Markets for Years 2003, 2008, & 2012 II-35
III. MARKET
1. The United States III-1
A.Market Analysis III-1
Current and Future Analysis III-1
Rising Demand for Paclitaxel III-1
Alarming Growth of Breast Cancer III-1
Clinical Research Favors Paclitaxel for Breast Cancer
Treatment III-1
Paclitaxel - An Important Element III-2
Corporate Talk III-2
Drug-Eluting Stents - Marching Ahead III-2
Strategic Corporate Developments III-2
Key Players III-7
B.Market Analytics III-10
Table 7: US Recent Past, Current & Future Analysis for Bulk
Paclitaxel Market with Annual Sales in Kilograms for Years
2000 through 2010 (includes corresponding Graph/Chart) III-10
Table 8: US Long-term Projections for Bulk Paclitaxel
Market with Annual Sales in Kilograms for Years 2011
through 2015.(includes corresponding Graph/Chart) III-10
Table 9: US Recent Past, Current & Future Analysis for Bulk
Paclitaxel Market with Annual Sales in US$ Million for
Years 2000 through 2010 (includes corresponding
Graph/Chart) III-11
Table 10: US Long-term Projections for Bulk Paclitaxel
Market with Annual Sales in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-11
2. Rest of World III-12
A.Market Analysis III-12
Current and Future Analysis III-12
Europe. III-12
European Market Overview III-12
European Market Battling Cost-Containment Woes III-12
Efforts to Improve the Scenario and their Effect on
Paclitaxel Market III-13
China. III-13
Chinese Government Strategizing to Save Paclitaxel Reserves III-13
Product Launches/Developments. III-13
Strategic Corporate Development III-14
Key Players III-20
B.Market Analytics III-22
Table 11: Rest of World Recent Past, Current & Future
Analysis for Bulk Paclitaxel Market with Annual Sales in
Kilograms for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-22
Table 12: Rest of World Long-term Projections for Bulk
Paclitaxel with Annual Sales in Kilograms for Years 2011
through 2015 (includes corresponding Graph/Chart) III-22
Table 13: Rest of World Recent Past, Current & Future
Analysis for Bulk Paclitaxel Market with Annual Sales in
US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-23
Table 14: Rest of World Long-term Projections for Bulk
Paclitaxel Market with Annual Sales in US$ Million for
Years 2011 through 2015 (includes corresponding
Graph/Chart). III-23
IV. COMPETITIVE LANDSCAPE
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