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CNS Therapeutics - Global Strategic Business Report

Price:
USD $3,950.00
ISBN/SKU #:
GIA-MCP1835
Research Group:
Global Industry Analysts
Date of Publication:
May 2008
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Summary

This report analyzes the worldwide markets for CNS Therapeutics in Millions of US$. The specific product Groups analyzed are Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain Management (includes Migraine, Nociceptive and neuropathic pain), Anti-Psychotics, Anti-Depressants, and Others (includes Multiple Sclerosis, Insomnia and ADHD). The report provides separate comprehensive analytics for the US, Canada, Europe, Asia-Pacific, Latin America, and Rest of World. Annual forecasts are provided for each region for the period of 2000 through 2015. The report profiles 131 companies including many key and niche players worldwide such as Abbott Laboratories, Akzo Nobel NV, Organon N.V., Alkermes, Inc., AstraZeneca PLC, Boehringer Ingelheim GmbH, Bristol-Myers Squibb, CeNeS Pharmaceuticals PLC, Cephalon, Inc., Dainippon Sumitomo Pharma Co., Ltd., Elan Corporation PLC, Eli Lilly and Co, Fabre-Kramer Pharmaceuticals, Inc., F. Hoffmann-La Roche Ltd., Forest Laboratories, Inc., GlaxoSmithKline, H. Lundbeck A/S, Johnson & Johnson, Janssen Pharmaceutica NV, Janssen-Cilag, Merck & Co, Inc., Neurocrine Biosciences, Inc., Novartis AG, Sandoz International GmbH, Organon N.V., Ortho-McNeil Neurologics, Inc., Otsuka Pharmaceutical Co., Ltd., Pfizer, Inc., Sanofi-Aventis, Schwarz Pharma AG, Sepracor, Inc., Shire PLC, Solvay Pharmaceuticals S.A., Takeda Pharmaceutical Co., Ltd., Teva Pharmaceutical Industries Ltd, UCB S.A., and Wyeth. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

TABLE OF CONTENTS:

CNS THERAPEUTICS								MCP-1835
A GLOBAL STRATEGIC BUSINESS REPORT


                                              CONTENTS


  I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
      Study Reliability and Reporting Limitations                       I-1
      Disclaimers                                                       I-2
      Data Interpretation & Reporting Level                             I-2
       Quantitative Techniques & Analytics                              I-3
      Product Definitions and Scope of Study                            I-3
       CNS Disorders                                                    I-3
        A. Anti-Alzheimer's Drugs                                       I-3
        B. Anti-Parkinson's Drugs                                       I-4
        C. Anti-Epilepsy Drugs                                          I-4
        D. Pain Management Drugs                                        I-4
        E. Anti-Psychotics Drugs                                        I-5
      (i) Bipolar disorder                                              I-5
      (ii) Schizophrenia                                                I-5
        F. Anti-Depressants Drugs                                       I-5
        G. Others                                                       I-6
      (i) Attention Deficit Hyperactivity Disorder                      I-6
      (ii) Multiple Sclerosis                                           I-6
      (iii) Insomnia                                                    I-6
      (iv) Restless Legs Syndrome                                       I-7
      (v) Anxiety                                                       I-7


 II. EXECUTIVE SUMMARY

  1. Industry Overview                                                  II-1
      Factors Influencing Demand                                        II-1
       The 'Age Factor'                                                 II-1
       Role of Diagnostic Techniques                                    II-1
       Increasing Disease Awareness                                     II-1
       Emergent Technologies                                            II-1
       Reimbursement Policies                                           II-2
      Market Trends and Issues                                          II-2
       Booming Therapeutic Opportunities for Neuro-Degenerative
        Disorders                                                       II-2
       Spur in CNS Drug Delivery Technologies                           II-2
       Migraine Market Offers Growth Opportunities to Prophylaxis
        Products                                                        II-3
       Demand for Therapeutic Peptides Spurred by Dearth of
        Effective Therapies                                             II-3
       Anti-Depressants                                                 II-3
        Major Trends in the Depression Market                           II-4
        SSRIs are the Preferred Choice Despite Side Effects             II-4
         Table 1: US Anti-Depressants Market (2004-2006): Sales of
         Leading Drug Brands - Zoloft, Effexor ER, Lexapro,
         Wellbutrin, Paxil, Celexa and Prozac (In US$M) (includes
         corresponding Graph/Chart)                                     II-5

         Table 2: Leading Brands in European Anti-Depressants Market
         (2005): Percentage Breakdown by Value Sales for Effexor,
         Zoloft, Paxil, Cipralex, Wellbutrin, Citalopram, Prozac,
         Remeron and Others (includes corresponding Graph/Chart)        II-5
       Attention Deficit Hyperactivity Disorder (ADHD)                  II-5
        Table 3: Worldwide ADHD Market (2005): Sales  of  Leading
        Drug Brands -Concerta, Adderall/  Adderall ER and Strattera
        (includes  corresponding Graph/Chart)                           II-6
        Major Trends in the ADHD Market:                                II-6
       Anti-Psychotics Market                                           II-6
        Restrictions on Promotion Hamper Market Prospects               II-7
         Table 4: Worldwide Atypical Anti-Psychotics Market (2004 &
         2005): Sales of Leading Drug Brands - Zyprexa, Risperdal,
         Seroquel, Abilify and Zeldox (includes corresponding
         Graph/Chart)                                                   II-7

         Table 5: Leading Brands in Worldwide Anti-Psychotics Market
         (Bipolar Disorder) (2003-2005): Percentage Breakdown by
         Value Sales for Zyprexa, Risperdal, Seroquel, Abilify and
         Others (includes corresponding Graph/Chart)                    II-8

         Table 6: Leading Brands in US Anti-Psychotics Market
         (2004-2006): Percentage Breakdown by Value Sales for
         Zyprexa, Risperdal, Seroquel, Depakote/ER, Abilify,
         Lamictal/XR, Geodon and Others (includes corresponding
         Graph/Chart)                                                   II-9

         Table 7: Leading Brands in European Atypical
         Anti-Psychotics Market (2004): Percentage Breakdown by
         Value Sales for Zyprexa, Risperdal/ Risperdal CONSTA,
         Seroquel, Solian, Risperidone, Geodon and Others (includes
         corresponding Graph/Chart)                                     II-10
       Insomnia                                                         II-10
        Anti-Insomnia Drugs from Corporate Giants Flood the Sleep
         Market                                                         II-10
       Neuropathic Pain                                                 II-10
        Table 8: Leading Players in the US Pain Management Market
        (2005): Percentage Breakdown by Value Sales for J&J, Endo
        Pharmaceuticals, Purdue Pharma, Cephalon, King/Ligand and
        Others (includes corresponding Graph/Chart)                     II-11
       Patent Expiry of Leading CNS Drugs: 2005-2017                    II-11

  2. Global Market Analysis                                             II-12
      By Region                                                         II-12
      By Segment                                                        II-12

  3. CNS Disorders - An Introduction                                    II-13
      Definition                                                        II-13
      Central Nervous System                                            II-13
      Mortality Threat of CNS Disorders                                 II-13
      Science of NMDA Receptors and its Disease Significance            II-13
      Major CNS Disorders:                                              II-14
       Alzheimer's Disease                                              II-14
        Alzheimer's Affect on Brain                                     II-14
        Causes for Alzheimer's                                          II-15
        Who Are at Risk?                                                II-15
        Prevalence of Alzheimer's Disease                               II-16
         Table 9: Incidence of Alzheimer's Disorder in Major US
         States: 2000-2025 (includes corresponding Graph/Chart)         II-16

         Table 10: Leading Brands in the US Anti-Alzheimer's Market
         (2004-2005): Percentage Breakdown by Value Sales for
         Aricept, Namenda, Razadyne/ Razadyne ER and Exelon
         (includes corresponding Graph/Chart)                           II-17
        Diagnosis of Alzheimer's                                        II-17
        Treatment for Alzheimer's                                       II-17
       Parkinson's Disease                                              II-18
        Table 11: Leading Brands in Worldwide Anti-Parkinson's
        Disease Market (2005): Percentage Breakdown by Value Sales
        for Mirapex, Requip, Cabaser, Madopar, Stalevo and Others
        (includes corresponding Graph/Chart)                            II-18
        Prevalence of Parkinson's                                       II-19
        Symptom of Parkinson's                                          II-19
        Causes of Parkinson's                                           II-19
        Parkinson's Diagnosis                                           II-20
        Therapies for Parkinson's                                       II-20
        Surgery: The Last Option                                        II-20
      Epilepsy                                                          II-21
       Table 12: Worldwide Epilepsy Market (2004-2005): Sales of
       Leading Drug Brands - Topamax, Lamictal, Depakote, Neurontin
       and Trileptal (In US$ Million) (includes corresponding
       Graph/Chart)                                                     II-21
       Therapies for Epilepsy                                           II-21
      Pain Management                                                   II-22
       Debilitating Effects of Pain                                     II-23
       Types of Pain                                                    II-23
       Acute Pain                                                       II-23
       Chronic Pain                                                     II-23
       Migraine                                                         II-23
       Neuropathic Pain                                                 II-23
       Nociceptive Pain                                                 II-24
       Pain Management Therapies                                        II-24
      Bipolar Disorder                                                  II-24
       Symptoms of Bipolar Disorder                                     II-24
       Therapies for Bipolar Disorder                                   II-25
      Schizophrenia                                                     II-25
       Symptoms of Schizophrenia                                        II-25
       Therapies for Schizophrenia                                      II-25
      Depression                                                        II-25
       Prevalence of Depression                                         II-26
       Causes of Depression                                             II-26
       Types of Depressive Disorders                                    II-26
       Available Treatment                                              II-26
        Tricyclic Antidepressants                                       II-27
        Monoamine Oxidase Inhibitors                                    II-27
        Lithium Salts                                                   II-27
       Working of Antidepressants                                       II-27
       Ranking of Antidepressants in Terms of Efficacy                  II-27
       Types of Antidepressants                                         II-28
        NMDA Receptor Antagonists                                       II-28
        NMDA Receptor (NMDAR)                                           II-28
        NMDA Receptor Agonists                                          II-28
        Acetylcholinesterase Inhibitors                                 II-28
        Selective Serotonin Reuptake Inhibitors (SSRIs)                 II-29
        Serotonin Noradrenaline Reuptake Inhibitors (SNRIs)             II-29
      Others Common CNS Disorders                                       II-30
       Attention Deficit Hyperactivity Disorder                         II-30
        Consequences of ADHD                                            II-30
        What Leads to ADHD?                                             II-31
        Treating ADHD                                                   II-31
       Multiple Sclerosis (MS)                                          II-31
        Types of Multiple Sclerosis                                     II-32
        Prevalence of MS                                                II-32
        Causes of MS                                                    II-32
        Myths Surrounding Multiple Sclerosis                            II-32
        Symptoms of MS                                                  II-33
        Diagnosis of MS                                                 II-33
        Therapies for MS                                                II-33
       Insomnia                                                         II-33
        Prevalence of Insomnia                                          II-33
        Therapies for Insomnia                                          II-34
       Restless Legs Syndrome                                           II-34
       Anxiety                                                          II-34

  4. Overview of Select CNS Drugs                                       II-35
      Anti-Alzheimer's Drugs                                            II-35
       Aricept                                                          II-35
       Exelon                                                           II-35
       Reminyl                                                          II-35
       Ebixa                                                            II-35
       Namenda                                                          II-35
      Anti-Parkinson's Drugs                                            II-36
       Levodopa                                                         II-36
       Dopamine Agonists                                                II-36
       Mirapex                                                          II-36
       Requip                                                           II-36
      Anti-Epilepsy Drugs                                               II-36
       Carbamazepine                                                    II-36
       Phenytoin                                                        II-36
       Lamictal                                                         II-37
       Depakote                                                         II-37
       Neurotonin                                                       II-37
      Pain Management                                                   II-37
       Duragesic                                                        II-37
       Metabotropic Glutamate Receptors (mGluRs)                        II-37
      Anti-Psychotics                                                   II-38
       Zyprexa                                                          II-38
       Seroquel                                                         II-38
       Abilify                                                          II-38
       Clozaril                                                         II-38
      Antidepressants Drugs                                             II-38
       Zoloft (Sertraline)                                              II-38
       Prozac (Fluoxetine)                                              II-39
       Effexor (Venlafaxine)                                            II-39
       Paxil                                                            II-39
       Wellbutrin (Bupropion)                                           II-39
      Attention Deficit Hyperactivity Disorder (ADHD)                   II-39
       Concerta                                                         II-39
       Strattera                                                        II-40
       Adderall                                                         II-40
      Insomnia                                                          II-40
       Estorra                                                          II-40
       Lunesta                                                          II-40

  5. Research & Development                                             II-41
      AstraZeneca, NPS Develop mGluRs for CNS Disorders                 II-41
      High Efavirenz Plasma Levels in HIV Patients Could Result in
       CNS Toxicity                                                     II-41
      Adenoviral Gene Therapy May Damage CNS                            II-41
      Role of B Cells in Damaging Nerve Fibers                          II-41
      Oral Administration of Antibodies Restrict Attacks in MS          II-42
      Country of Birth/Dwelling Influences Risk of Multiple Sclerosis   II-42
      Levetiracetam is Effective in Epilepsy Prevention                 II-42
      Nicotine Guards Against Parkinson's-Like Disease                  II-42
      Parkinson's Drugs May Influence Addictions                        II-43
      Dopamine Induces Sleep and Brain Activity                         II-43
      Researchers Link Obesity to Dementia                              II-43
      High Folate Consumption Mitigates Risks to Alzheimer's Disease    II-43
      Consistent Depression Treatment Likely to Prevent Relapse         II-43
      Animal Research Model Highlights Difficulties of Depression
       Syndrome                                                         II-43
      Hypnion Announces Encouraging Results for HY10275                 II-44
      Antihistamine Effective In Mitigating Alzheimer's Disorder        II-44
      Novartis' Fingolimod Alleviate MS Activity                        II-44
      Lundbeck Initiates Trials of its Novel Anti-Psychotic Drug        II-44
      Cara Develops CR665 for Pain Management                           II-44
      Gepirone ER of Fabre-Kramer Effective in Depression               II-44
      Biogen Idec Discovers Molecule for Treatment of CNS Disorders     II-45
      Teva Claims Copaxone as the Ultimate in Treating MS               II-45
      Biogen Idec and Elan Corp. Conclude Safety Evaluation of Tysabri II-45
      Cognetix Files Provisional Patent for Screening Methods of
       CGX-1160                                                         II-45
      NeuroSearch's NS2330 Fail to Meet Efficacy Standards in Trials    II-45
      Medtronic Undertakes Trials to Study Treatment Resistant
       Depression                                                       II-45
      National MS Society to Initiate Efforts to Identify MS
       Influencing Genetics                                             II-45
      Academic Data Supports COMT Inhibitors Performance in Parkinson's II-46
      MS Ireland Supports Return of Tysabri                             II-46
      Cigarette Smoking Increases Risks of Multiple Sclerosis           II-46
      Study of Parkinson's Incidence in Zambia, Russia and Uzbekistan   II-46
      Encouraging Developments in Animal Model of Parkinson's Disease   II-46

  6. Product Innovations/Introductions                                  II-47
      Biogen and Elan Introduces Tysabri in Europe                      II-47
      Medtronic Launches Activa for Parkinson's Disease                II-47
      Tysabri Obtains Canadian Approval For Multiple Sclerosis          II-47
      Lundbeck Unveils Serdolect Available in Estonia                  II-47
      OPC, Bristol-Myers Unveil Abilify Discmelt                      II-47
      OPC Introduces Anti-Psychotic Drug Abilify in Japan               II-47
      FDA Approves Novartis' Exelon for Parkinson's                     II-48
      Ono Pharmaceutical, Novartis Develops Transdermal Patch for
       Alzheimer's                                                      II-48
      Zydus Cadila Drugs Flood the French Pharmaceutical Market         II-48
      Schwarz Pharma Develops Anti-Parkinson's Drug                     II-48
      Azilect Enters European Market                                   II-48
      Lilly Launches Therapy for Bipolar Disorder                       II-48

  7. Recent Industry Activity                                           II-49
      P1vital Creates Global Consortium to Develop  CNS Experimental
       Medicine                                                         II-49
      Neurobiological Tech Teams Up with Buck Institute                 II-49
      ExonHit Therapeutics and Allergan Ink Contract to  Develop CNS
       Agents                                                           II-49
      NeuroSearch Commences Clinical Phase I study  with NSD-788 in
       France                                                           II-49
      Abilify Meets CHMP Standards                                     II-49
      UCB Receives Recommendation for Approval for  Neupro             II-49
      Schering-Plough Acquires Organon                                  II-50
      UCB Launches Neupro in the US                                    II-50
      GlaxoSmithKline Forms Alliance with Targacept                     II-50
      GSK Teams-Up with Sepracor for Commercializing  Lunivia          II-50
      US FDA Rebut NDA for bifeprunox                                   II-51
      Medtronic and Alnylam Extend their Drug-Device  Collaboration     II-51
      Neuren Takes Over Hamilton                                        II-51
      Roche Forms Partnership with Synosis Therapeutics to  Evaluate
       Five CNS Compounds                                               II-51
      NeuroSearch Starts Clinical Phase I Study with ACR343  in Sweden  II-51
      Lundbeck to Promote Circadin in Europe                           II-51
      Sepracor Inks Partnership with Eisai to Develop and  Market
       Lunesta in Japan                                                II-52
      Neurologix Obtains License of Gene Therapy Component              II-52
      Prestwick Raises Fund to Finance CNS Projects                     II-52
      Kyowa Inks Agreement with Britannia                               II-52
      China Aoxing Pharmaceutical Receives Product Approvals            II-53
      China Aoxing Acquires Hebei Aoxing                                II-53
      AlphaRx Partners with Israel based PharmSeed Ltd                  II-53
      Nippon Boehringer Markets CNS Drugs on Portals                    II-53
      FDA Approves Tysabri for treating MS                              II-53
      CeNeS Acquires Certain IP Rights from ALZA                        II-53
      Belgium based UCB Acquires Schwarz Pharma                         II-54
      Axaron and LION Bioscience Establish New Company                  II-54
      Ceregene Obtains Grant for Phase II Trial                         II-54
      Shire Obtains Anti-Epileptic Drug License from Yissum             II-54
      TorreyPines and Axonyx Conclude Merger Operations                 II-54
      VistaGen Enters Into Strategic Partnership with Cato BioVentures  II-54
      Organon Announces Partnership with BrainCells                     II-55
      Alkermes Inks Licensing Agreement with Rensselaer                 II-55
      FDA Approves SEROQUEL Therapy for Bipolar Indication             II-55
      Boehringer Ingelheim, Eli Lilly Modify Agreement Terms            II-55
      Boston Life Sciences Signs Licensing Agreement with Children's
       Hospital                                                         II-55
      CeNeS, Tripos Extend Research Collaboration                       II-55
      CeNeS Partners Ergomed for CNS 5161 Phase II Clinical Trial       II-56
      CeNeS' Short-Acting Sedative Obtains Patent                       II-56
      Takeda and Cephalon Collaborate Over Provigil                    II-56
      Eli Lilly Files sNDA for Cymbalta                                II-56
      GlaxoSmithKline Obtains FDA Approval for Lamictal                II-56
      Serono Acquires Safinamide License from Neuron                    II-56
      Neurocrine Files NDA for Anti-Insomnia Drug Indiplon              II-56
      Novartis Inks Agreement with Servier, Idenix                      II-57
      NPS Extends Alliance with AstraZeneca                             II-57
      Pfizer's Lyrica Receives Approval for Neuropathic Pain           II-57
      Schwarz Pharma Receives FDA Approval of Neupro                   II-57
      Teva's Azilect tablets Approved in Canada                        II-57
      Teva and Eisei Terminate Joint Marketing Alliance                 II-57
      FDA Approves Teva's Azilect for Parkinson's Disorder             II-58
      UCB's Keppra Obtains FDA Approval to Treat Epilepsy              II-58
      Wyeth, Solvay Pharmaceuticals Files NDA for Schizophrenia Drug    II-58
      D-Pharm Licenses DP-b99 Drug to Yungjin                           II-58
      Eli Lilly, Suven Collaborate Over CNS Therapies                   II-58
      IVAX to Develop Oral Therapy for Multiple Sclerosis               II-58
      Thomson Takes Over Cipher's Business Unit                         II-58
      CLL Pharma Acquires Synt: em SA                                   II-59
      Ranbaxy Acquires Advent's Subsidiary                              II-59
      Shire Receives Approval of Daytrana for Treating ADHD Disorder    II-59
      Shire Inks Marketing Agreement with New River                     II-59
      Acadia and Sepracor in a Collaborative R&D Deal                   II-59
      Ablynx Partners with National Research Council of Canada          II-59
      Bristol Myers and Albany Sign Licensing Agreement                 II-60
      Andara Secures Licenses to Purdue's Treatment Alternatives        II-60
      Otsuka Ties Up with Galenea to Develop CNS drugs                  II-60
      Novartis Inks Distribution Agreement with Alfresa Pharma          II-60
      Dainippon Commences Operations of New Facility                    II-60
      Ranbaxy Purchases Generic Product Line of Efarmes                 II-60
      Novasite Takes Over PsyCheNomicS                                  II-61
      Organon Returns Gepirone ER Rights to Fabre-Kramer                II-61
      Teva Expands Operations in India                                  II-61
      Neurologix Acquires License to Alzheimer's Treating Gene          II-61
      Meda Takes Over Viatris                                           II-61
      Evotec Acquires Majority Stake in Evotec Neurosciences            II-61
      IVAX Merges with Teva Pharmaceutical                              II-62
      Wyeth Files NDA for Anti-Depressant Drug DVS-233                  II-62
      Schwarz Pharma Acquires Rights of Rotigotine                      II-62
      Shire Submits NDA for Two ADHD Drugs                              II-62
      Takeda and Paradigm Collaborate to Develop CNS Therapies          II-62
      Sanofi's Ambien CR to Induce and Maintain Sleep in the US        II-62
      NeuroSearch Initiates Phase I Clinical Study of ABT- 894          II-62
      NeuroSearch Receives Euro 10 Million as Milestone Payments for
       NS2359                                                           II-62
      FDA Approves Depakote ER for Bipolar Disorder Treatment          II-63
      Alkermes Receives Approval for Risperdal Consta in Italy         II-63
      AstraZeneca Signs Research Collaboration Deal with Targacept      II-63
      Cymbalta / Xeristar Treatment Approved for Depression in Europe II-63
      FDA Grants SPA Status to Boston Life's Altropane                 II-63
      Sumitomo Merges with Dainippon                                    II-63
      Cipralex Therapy Extended to GAD in Europe                       II-63
      Johnson & Johnson Submits Paliperidone ER for NDA                 II-64
      Spectrum Acquires License of CNS Cancer Therapeutic Drug          II-64
      Multiple Sclerosis Drug Tysabri Pulled Off Market                 II-64
      Roche Partners with GE Healthcare                                 II-64
      New River to Develop Pain Management Therapies                    II-64
      Elekta Takes Over IMPAC Medical Systems                           II-64
      Eli Lilly Acquires Merck's Product Compound for Insomnia          II-64
      Prestwick Raises Funds to Develop CNS Therapies                   II-65
      Aspect Medical Acquires Exclusive Rights to Cordance Technology   II-65
      Bristol-Myers Pulls Out Serzone from the US Market                II-65
      Paladin Inks Agreement with Ovation                               II-65
      Acorda Raises Funds For Therapy Development                       II-65
      Wyeth Sells Indiplon Ownership Rights to Neurocrine               II-65
      Micrologix Takes Over Mitokor                                     II-66
      Sanofi Merges with Aventis to Form a New Company                  II-66
      VistaGen Takes Over Artemis                                       II-66
      Neuro Bioscience Acquires Majority Stake in CLL Pharma            II-66
      Tiger Brands Acquires Pfizer's Subsidiary                         II-66
      Pfizer Acquires Asenapine License from Organon                    II-66

  8. Focus on Select Global Players                                     II-67
      Abbott Laboratories (USA)                                         II-67
      Alkermes, Inc. (USA)                                              II-67
      AstraZeneca Plc (UK)                                              II-67
      Boehringer Ingelheim GmbH (Germany)                               II-67
      Bristol-Myers Squibb (USA)                                        II-68
      CeNeS Pharmaceuticals Plc (UK)                                    II-68
      Cephalon, Inc. (USA)                                              II-68
      Dainippon Sumitomo Pharma Co., Ltd. (Japan)                       II-69
      Elan Corporation Plc (Ireland)                                    II-69
      Eli Lilly and Co. (USA)                                           II-69
      Fabre-Kramer Pharmaceuticals, Inc. (USA)                          II-70
      F. Hoffmann-La Roche Ltd. (Switzerland)                           II-70
      Forest Laboratories, Inc. (USA)                                   II-70
      GlaxoSmithKline (UK)                                              II-70
      H. Lundbeck A/S (Denmark)                                         II-71
      Johnson & Johnson (USA)                                           II-71
       Janssen Pharmaceutica N.V. (Belgium)                             II-71
       Janssen-Cilag (Switzerland)                                      II-71
      Merck & Co, Inc. (USA)                                            II-71
      Neurocrine Biosciences, Inc. (USA)                                II-72
      Novartis AG (Switzerland)                                         II-72
       Sandoz International GmbH (Germany)                              II-72
      Organon N.V. (The Netherlands)                                    II-73
      Ortho-McNeil Neurologics, Inc. (USA)                              II-73
      Otsuka Pharmaceutical Co., Ltd. (Japan)                           II-73
      Pfizer, Inc. (USA)                                                II-73
      Sanofi-Aventis (France)                                           II-74
      Schwarz Pharma AG (Germany)                                       II-74
      Sepracor, Inc. (USA)                                              II-74
      Shire Plc (UK)                                                    II-74
      Solvay Pharmaceuticals S.A. (France)                              II-75
      Takeda Pharmaceutical Co., Ltd. (Japan)                           II-75
      Teva Pharmaceutical Industries Ltd. (Israel)                      II-75
      UCB S.A. (Belgium)                                                II-75
      Wyeth (USA)                                                       II-76

  9. Global Market Perspective                                          II-77
      Table 13: World Recent Past, Current & Future Analysis for CNS
      Therapeutics by Geographic Region - USA, Canada, Europe,
      Asia-Pacific (including Japan), Latin America and  Rest of
      World Markets Independently Analyzed with Annual Sales Figures
      in US$ Million for Years 2000 through 2010 (includes
      corresponding Graph/Chart)                                        II-77

      Table 14: World Long-term Projections for CNS Therapeutics  by
      Geographic Region - USA, Canada, Europe, Asia-Pacific
      (including Japan), Latin America and Rest of World Markets
      Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2011 through 2015 (includes  corresponding
      Graph/Chart)                                                      II-78

      Table 15: World 10-Year Perspective for CNS Therapeutics by
      Geographic Region - Percentage Breakdown of Dollar Sales  for
      USA, Canada, Europe, Asia-Pacific (including Japan),  Latin
      America and Rest of World Markets for Years 2003,  2008 & 2012
      (includes corresponding Graph/Chart)                              II-79

      Table 16: World Recent Past, Current & Future Analysis for
      Anti-Alzheimer's Drugs by Geographic Region - USA, Canada,
      Europe, Asia-Pacific (including Japan), Latin America and
      Rest of World Markets Independently Analyzed with Annual Sales
      Figures in US$ Million for Years 2000 through  2010 (includes
      corresponding Graph/Chart)                                        II-80

      Table 17: World Long-term Projections for Anti-Alzheimer's
      Drugs by Geographic Region - USA, Canada, Europe, Asia-Pacific
      (including Japan), Latin America and Rest of World Markets
      Independently Analyzed with Annual Sales Figures  in US$
      Million for Years 2011 through 2015 (includes corresponding
      Graph/Chart)                                                      II-81

      Table 18: World 10-Year Perspective for Anti-Alzheimer's Drugs
      by Geographic Region - Percentage Breakdown of Dollar Sales
      for USA, Canada, Europe, Asia-Pacific (including Japan),
      Latin America and Rest of World Markets for Years 2003,  2008
      & 2012 (includes corresponding Graph/Chart)                       II-82

      Table 19: World Recent Past, Current & Future Analysis for
      Anti-Parkinson's Drugs by Geographic Region - USA, Canada,
      Europe, Asia-Pacific (including Japan), Latin America and
      Rest of World Markets Independently Analyzed with Annual Sales
      Figures in US$ Million for Years 2000 through  2010 (includes
      corresponding Graph/Chart)                                        II-83

      Table 20: World Long-term Projections for Anti-Parkinson's
      Drugs by Geographic Region - USA, Canada, Europe, Asia-Pacific
      (including Japan), Latin America and Rest of World Markets
      Independently Analyzed with Annual Sales Figures  in US$
      Million for Years 2011 through 2015 (includes corresponding
      Graph/Chart)                                                      II-84

      Table 21: World 10-Year Perspective for Anti-Parkinson's Drugs
      by Geographic Region - Percentage Breakdown of Dollar Sales
      for USA, Canada, Europe, Asia-Pacific (including Japan), Latin
      America and Rest of World Markets for Years 2003, 2008 & 2012
      (includes corresponding Graph/Chart)                              II-85

      Table 22: World Recent Past, Current & Future Analysis for
      Anti-Epilepsy Drugs by Geographic Region - USA, Canada,
      Europe, Asia-Pacific (including Japan), Latin America and
      Rest of World Markets Independently Analyzed with Annual Sales
      Figures in US$ Million for Years 2000 through  2010 (includes
      corresponding Graph/Chart)                                        II-86

      Table 23: World Long-term Projections for Anti-Epilepsy Drugs
      by Geographic Region - USA, Canada, Europe, Asia-Pacific
      (including Japan), Latin America and Rest of World Markets
      Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2011 through 2015 (includes  corresponding
      Graph/Chart)                                                      II-87

      Table 24: World 10-Year Perspective for Anti-Epilepsy Drugs
      by Geographic Region - Percentage Breakdown of Dollar Sales
      for USA, Canada, Europe, Asia-Pacific (including Japan), Latin
      America and Rest of World Markets for Years 2003, 2008 & 2012
      (includes corresponding Graph/Chart)                              II-88

      Table 25: World Recent Past, Current & Future Analysis  for
      Pain Management Drugs by Geographic Region - USA, Canada,
      Europe, Asia-Pacific (including Japan),  Latin America and
      Rest of World Markets Independently Analyzed with Annual Sales
      Figures in US$ Million for  Years 2000 through 2010 (includes
      corresponding  Graph/Chart)                                       II-89

      Table 26: World Long-term Projections for Pain Management
      Drugs by Geographic Region - USA, Canada, Europe, Asia-Pacific
      (including Japan), Latin America and Rest of World Markets
      Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2011 through 2015 (includes corresponding
      Graph/Chart)                                                      II-90

      Table 27: World 10-Year Perspective for Pain Management Drugs
      by Geographic Region - Percentage Breakdown of  Dollar Sales
      for USA, Canada, Europe, Asia-Pacific  (including Japan),
      Latin America and Rest of World Markets  for Years 2003, 2008
      & 2012 (includes corresponding Graph/Chart)                       II-91

      Table 28: World Recent Past, Current & Future Analysis for
      Anti-Psychotics Drugs by Geographic Region - USA, Canada,
      Europe, Asia-Pacific (including Japan), Latin America and
      Rest of World Markets Independently Analyzed with Annual Sales
      Figures in US$ Million for Years 2000 through  2010 (includes
      corresponding Graph/Chart)                                        II-92

      Table 29: World Long-term Projections for Anti-Psychotics
      Drugs by Geographic Region - USA, Canada, Europe, Asia-Pacific
      (including Japan), Latin America and Rest of World Markets
      Independently Analyzed with Annual Sales Figures  in US$
      Million for Years 2011 through 2015 (includes corresponding
      Graph/Chart)                                                      II-93

      Table 30: World 10-Year Perspective for Anti-Psychotics  Drugs
      by Geographic Region - Percentage Breakdown of Dollar Sales
      for USA, Canada, Europe, Asia-Pacific (including Japan), Latin
      America and Rest of World Markets for Years 2003, 2008 & 2012
      (includes corresponding Graph/Chart)                              II-94

      Table 31: World Recent Past, Current & Future Analysis for
      Anti-Depressants Drugs by Geographic Region - USA, Canada,
      Europe, Asia-Pacific (including Japan), Latin America and
      Rest of World Markets Independently Analyzed with Annual Sales
      Figures in US$ Million for Years 2000 through 2010 (includes
      corresponding Graph/Chart)                                        II-95

      Table 32: World Long-term Projections for Anti-Depressants
      Drugs by Geographic Region - USA, Canada, Europe, Asia-Pacific
      (including Japan), Latin America and Rest of World Markets
      Independently Analyzed with Annual Sales Figures  in US$
      Million for Years 2011 through 2015 (includes corresponding
      Graph/Chart)                                                      II-96

      Table 33: World 10-Year Perspective for Anti-Depressants Drugs
      by Geographic Region - Percentage Breakdown of  Dollar Sales
      for USA, Canada, Europe, Asia-Pacific  (including Japan),
      Latin America and Rest of World Markets  for Years 2003, 2008
      & 2012 (includes corresponding Graph/Chart)                       II-97

      Table 34: World Recent Past, Current & Future Analysis for
      Other Drugs by Geographic Region - USA, Canada, Europe,
      Asia-Pacific (including Japan), Latin America and Rest of
      World Markets Independently Analyzed with Annual Sales Figures
      in US$ Million for Years 2000 through 2010 (includes
      corresponding Graph/Chart)                                        II-98

      Table 35: World Long-term Projections for Other Drugs by
      Geographic Region - USA, Canada, Europe, Asia-Pacific
      (including Japan), Latin America and Rest of World Markets
      Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2011 through 2015 (includes  corresponding
      Graph/Chart)                                                      II-99

      Table 36: World 10-Year Perspective for Other Drugs by
      Geographic Region - Percentage Breakdown of Dollar Sales for
      USA, Canada, Europe, Asia-Pacific (including Japan), Latin
      America and Rest of World Markets for Years 2003, 2008 & 2012
      (includes corresponding Graph/Chart)                              II-100


III. MARKET

  1. The United States                                                  III-1
      A.Market Analysis                                                 III-1
        Current & Future Analysis                                       III-1
        Cost Implications of CNS Disorders                              III-1
        Alzheimer's Market                                              III-1
         Table 37: Incidence of Alzheimer's Disorder in Major US
         States: 2000-2025 (includes corresponding Graph/Chart)         III-2
         Anti-Alzheimer's Drugs Approved for Use in the Past            III-2
          Table 38: Leading Brands in the US Anti-Alzheimer's Market
          (2004 & 2005): Percentage Breakdown by Value Sales for
          Aricept, Namenda, Razadyne / Razadyne ER and Exelon
          (includes corresponding Graph/Chart)                          III-3
         Cost of Care to AD Patient                                     III-3
         Clinical Pipeline                                              III-3
        Anti-Psychotics                                                 III-3
         Growth Dampeners                                               III-4
         Clinical Pipeline                                              III-4
          Table 39: Leading Brands in US Anti-Psychotics Market
          (2004-2006): Percentage Breakdown by Value Sales for
          Zyprexa, Risperdal, Seroquel, Depakote/ER, Abilify,
          Lamictal/XR, Geodon and Others (includes corresponding
          Graph/Chart)                                                  III-5

          Table 40: Leading Brands in US Atypical Anti-Psychotics
          Market (2004, 2006 & 2008): Percentage Breakdown by Value
          Sales for Zyprexa, Risperdal/ Risperdal CONSTA, Seroquel,
          Abilify, Geodon and Others (includes corresponding
          Graph/Chart)                                                  III-5
        Antidepressants                                                 III-6
         Antidepressants to Feature Black-Box Warnings                  III-6
         Antidepressant Consumption Falls Among Children and
          Adolescents                                                   III-6
          Table 41: US Anti-Depressants Market (2004-2006): Sales of
          Leading Drug Brands - Zoloft, Effexor ER, Lexapro,
          Wellbutrin, Paxil, Celexa and Prozac (includes
          corresponding Graph/Chart)                                    III-6
        Multiple Sclerosis                                              III-7
         Table 42: Leading Anti-Multiple Sclerosis Drugs in the US
         (2004): Percentage Breakdown of Value Sales for Avonex,
         Copaxone, Rebif and Betaseron (includes corresponding
         Graph/Chart)                                                   III-7
        Insomnia Market                                                 III-7
        Rising Consumption of ADHD Drugs Combat Safety Concerns         III-7
         Table 43: US ADHD Market (2005): Percentage Breakdown of
         Sales by Leading Brands - Concerta, Strattera, Ritalin,
         Metadate, Focalin XR and Others (includes corresponding
         Graph/Chart)                                                   III-8
        Unmet Medical Needs in Neuropathic Pain Offer Growth Prospects  III-8
         Table 44: Leading Players in the US Pain Management Market
         (2005-2007): Percentage Breakdown by Value Sales for J&J,
         ENDO, Purdue, Cephalon, King/Ligand and Others (includes
         corresponding Graph/Chart)                                     III-8
       CNS Tuberculosis Raises its Ugly Head                            III-9
       Product Launches/Developments                                    III-9
       Strategic Corporate Developments                                 III-10
       Key Players                                                      III-20
      B.Market Analytics                                                III-26
        Table 45: US Recent Past, Current & Future Analysis for CNS
        Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures  in US$
        Million for Years 2000 through 2010  (includes corresponding
        Graph/Chart)                                                    III-26

        Table 46: US Long-term Projections for CNS Therapeutics by
        Product Group - Anti-Alzheimer's, Anti-Parkinson's,
        Anti-Epilepsy, Pain Management, Anti-Psychotics,
        Anti-Depressants and Other Markets Independently Analyzed
        with Annual Sales Figures in US$ Million  for Years 2011
        through 2015 (includes  corresponding Graph/Chart)              III-27

        Table 47: US 10-Year Perspective for CNS Therapeutics by
        Product Group - Percentage Breakdown of Dollar Sales for
        Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
        Management, Anti-Psychotics, Anti-Depressants and  Other
        Markets for Years 2003, 2008 & 2012  (includes corresponding
        Graph/Chart)                                                    III-28

  2. Canada                                                             III-29
      A.Market Analysis                                                 III-29
        Current & Future Analysis                                       III-29
        Facts & Figures                                                 III-29
        Strategic Corporate Developments                                III-29
        Neurochem, Inc. - A Major Player                                III-30
      B.Market Analytics                                                III-31
        Table 48: Canadian Recent Past, Current & Future Analysis
        for CNS Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures  in US$
        Million for Years 2000 through 2010  (includes corresponding
        Graph/Chart)                                                    III-31

        Table 49: Canadian Long-term Projections for CNS
        Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures  in US$
        Million for Years 2011 through 2015  (includes corresponding
        Graph/Chart)                                                    III-32

        Table 50: Canadian 10-Year Perspective for CNS Therapeutics
        by Product Group - Percentage Breakdown  of Dollar Sales for
        Anti-Alzheimer's, Anti-Parkinson's,  Anti-Epilepsy, Pain
        Management, Anti-Psychotics,  Anti-Depressants and Other
        Markets for  Years 2003, 2008 & 2012 (includes
        corresponding Graph/Chart)                                      III-33

  3. Europe                                                             III-34
      A.Market Analysis                                                 III-34
        Current & Future Analysis                                       III-34
         By Region                                                      III-34
         By Product Segment                                             III-34
        Anti-Psychotics Market                                          III-34
         Table 51: European Anti-Psychotics Market (2002-2006):
         Percentage Breakdown of Revenues by Product Class -
         Atypical Anti-Psychotics Drugs and Traditional
         Anti-Psychotics Drugs (includes corresponding Graph/Chart)     III-34

         Table 52: Leading Brands in European Atypical
         Anti-Psychotics Market (2004): Percentage Breakdown by
         Value Sales for Zyprexa, Risperdal/ Risperdal CONSTA,
         Seroquel, Solian, Risperidone, Geodon and Others (includes
         corresponding Graph/Chart)                                     III-35
        European CNS Market Offers Untapped Opportunities               III-35
        Competitive Scenario of CNS Drug Market                         III-35
        Challenges Faced by the Antidepressants Market                  III-35
         Table 53: Leading Brands in European Anti-Depressants
         Market (2005): Percentage Breakdown by Value Sales for
         Effexor, Zoloft, Paxil, Cipralex, Wellbutrin, Citalopram,
         Prozac, Remeron and Others (includes corresponding
         Graph/Chart)                                                   III-36

         Table 54: European Anti-Depressants Market (2004-2006):
         Percentage Breakdown of Revenues by Segment - SSRI, SNRI
         and Others (includes corresponding Graph/Chart)                III-36
        Product Launches/Developments                                   III-36
        Strategic Corporate Developments                                III-37
        Key Players                                                     III-42
      B.Market Analytics                                                III-47
        Table 55: European Recent Past, Current & Future Analysis
        for CNS Therapeutics by Geographic Region - France, Germany,
        Italy, UK, Spain and Rest of Europe Markets Independently
        Analyzed with Annual Sales Figures in US$ Million for Years
        2000 through 2010 (includes corresponding Graph/Chart)          III-47

        Table 56: European Long-term Projections for CNS
        Therapeutics by Geographic Region - France, Germany, Italy,
        UK, Spain and Rest of Europe Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2011
        through 2015 (includes corresponding Graph/Chart)               III-48

        Table 57: European Recent Past, Current & Future Analysis
        for CNS Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2000 through 2010 (includes corresponding
        Graph/Chart)                                                    III-49

        Table 58: European Long-term Projections for CNS
        Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures  in US$
        Million for Years 2011 through 2015  (includes corresponding
        Graph/Chart)                                                    III-50

        Table 59: European 10-Year Perspective for CNS Therapeutics
        by Geographic Region - Percentage Breakdown of Dollar Sales
        for France, Germany, Italy, UK, Spain and Rest of Europe
        Markets for Years 2003, 2008 & 2012  (includes corresponding
        Graph/Chart)                                                    III-51

        Table 60: European 10-Year Perspective for CNS Therapeutics
        by Product Group - Percentage  Breakdown of Dollar Sales for
        Anti-Alzheimer's,  Anti-Parkinson's, Anti-Epilepsy, Pain
        Management,  Anti-Psychotics, Anti-Depressants and Other
        Markets  for Years 2003, 2008 & 2012 (includes
        corresponding Graph/Chart)                                      III-52

  3a. France                                                            III-53
      A.Market Analysis                                                 III-53
        Current & Future Analysis                                       III-53
        Healthcare System in France                                     III-53
      B.Market Analytics                                                III-54
        Table 61: French Recent Past, Current & Future  Analysis for
        CNS Therapeutics by Product Group -  Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants  and Other Markets
        Independently Analyzed with  Annual Sales Figures in US$
        Million for Years 2000  through 2010 (includes corresponding
        Graph/Chart)                                                    III-54

        Table 62: French Long-term Projections for CNS Therapeutics
        by Product Group - Anti-Alzheimer's,  Anti-Parkinson's,
        Anti-Epilepsy, Pain Management,  Anti-Psychotics,
        Anti-Depressants and Other Markets Independently Analyzed
        with Annual Sales Figures  in US$ Million for Years 2011
        through 2015  (includes corresponding Graph/Chart)              III-55

        Table 63: French 10-Year Perspective for CNS  Therapeutics
        by Product Group - Percentage Breakdown  of Dollar Sales for
        Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
        Management, Anti-Psychotics, Anti-Depressants and Other
        Markets for Years 2003, 2008 & 2012 (includes corresponding
        Graph/Chart)                                                    III-56

  3b. Germany                                                           III-57
      A.Market Analysis                                                 III-57
        Current & Future Analysis                                       III-57
        Healthcare System in Germany                                    III-57
        Reimbursement Policy                                            III-57
      B.Market Analytics                                                III-58
        Table 64: German Recent Past, Current & Future Analysis for
        CNS Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures  in US$
        Million for Years 2000 through 2010  (includes corresponding
        Graph/Chart)                                                    III-58

        Table 65: German Long-term Projections for CNS Therapeutics
        by Product Group - Anti-Alzheimer's,  Anti-Parkinson's,
        Anti-Epilepsy, Pain Management,  Anti-Psychotics,
        Anti-Depressants and Other Markets Independently Analyzed
        with Annual Sales Figures  in US$ Million for Years 2011
        through 2015  (includes corresponding Graph/Chart)              III-59

        Table 66: German 10-Year Perspective for CNS Therapeutics by
        Product Group - Percentage Breakdown  of Dollar Sales for
        Anti-Alzheimer's, Anti-Parkinson's,  Anti-Epilepsy, Pain
        Management, Anti-Psychotics,  Anti-Depressants and Other
        Markets for  Years 2003, 2008 & 2012 (includes
        corresponding Graph/Chart)                                      III-60

  3c. Italy                                                             III-61
      A.Market Analysis                                                 III-61
        Current & Future Analysis                                       III-61
        Healthcare System in Italy                                      III-61
        Market Snapshots                                                III-61
      B.Market Analytics                                                III-62
        Table 67: Italian Recent Past, Current & Future Analysis for
        CNS Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures  in US$
        Million for Years 2000 through 2010  (includes corresponding
        Graph/Chart)                                                    III-62

        Table 68: Italian Long-term Projections for CNS Therapeutics
        by Product Group - Anti-Alzheimer's,  Anti-Parkinson's,
        Anti-Epilepsy, Pain Management,  Anti-Psychotics,
        Anti-Depressants and Other Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2011
        through 2015 (includes corresponding Graph/Chart)               III-63

        Table 69: Italian 10-Year Perspective for CNS Therapeutics
        by Product Group - Percentage Breakdown of Dollar Sales for
        Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
        Management, Anti-Psychotics, Anti-Depressants and  Other
        Markets for Years 2003, 2008 & 2012  (includes corresponding
        Graph/Chart)                                                    III-64

  3d. The United Kingdom                                                III-65
      A.Market Analysis                                                 III-65
        Current & Future Analysis                                       III-65
        Healthcare System in the UK                                     III-65
        NICE Recommendations on CNS Therapeutics                        III-65
      B.Market Analytics                                                III-66
        Table 70: UK Recent Past, Current & Future Analysis for CNS
        Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures  in US$
        Million for Years 2000 through 2010  (includes corresponding
        Graph/Chart)                                                    III-66

        Table 71: UK Long-term Projections for CNS Therapeutics by
        Product Group - Anti-Alzheimer's, Anti-Parkinson's,
        Anti-Epilepsy, Pain Management, Anti-Psychotics,
        Anti-Depressants and Other Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for  Years 2011
        through 2015 (includes  corresponding Graph/Chart)              III-67

        Table 72: UK 10-Year Perspective for CNS Therapeutics  by
        Product Group - Percentage Breakdown of Dollar Sales for
        Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
        Management, Anti-Psychotics, Anti-Depressants and Other
        Markets for Years 2003, 2008 & 2012 (includes corresponding
        Graph/Chart)                                                    III-68

  3e. Spain                                                             III-69
      A.Market Analysis                                                 III-69
        Current & Future Analysis                                       III-69
        Healthcare System in Spain                                      III-69
      B.Market Analytics                                                III-70
        Table 73: Spanish Recent Past, Current & Future Analysis for
        CNS Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures  in US$
        Million for Years 2000 through 2010  (includes corresponding
        Graph/Chart)                                                    III-70

        Table 74: Spanish Long-term Projections for CNS Therapeutics
        by Product Group - Anti-Alzheimer's,  Anti-Parkinson's,
        Anti-Epilepsy, Pain Management,  Anti-Psychotics,
        Anti-Depressants and Other Markets Independently Analyzed
        with Annual Sales Figures  in US$ Million for Years 2011
        through 2015  (includes corresponding Graph/Chart)              III-71

        Table 75: Spanish 10-Year Perspective for CNS Therapeutics
        by Product Group - Percentage Breakdown  of Dollar Sales for
        Anti-Alzheimer's, Anti-Parkinson's,  Anti-Epilepsy, Pain
        Management, Anti-Psychotics,  Anti-Depressants and Other
        Markets for  Years 2003, 2008 & 2012 (includes
        corresponding Graph/Chart)                                      III-72

  3f. Rest of Europe                                                    III-73
      A.Market Analysis                                                 III-73
        Current & Future Analysis                                       III-73
        Overview of Select Markets                                      III-73
         Belgium                                                        III-73
         Finland                                                        III-73
         Scandinavia                                                    III-73
         Sweden                                                         III-74
         The Netherlands                                                III-74
      B.Market Analytics                                                III-74
        Table 76: Rest of Europe Recent Past, Current & Future
        Analysis CNS Therapeutics by Product Group -
        Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
        Management, Anti-Psychotics, Anti-Depressants and  Other
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-74

        Table 77: Rest of Europe Long-term Projections for CNS
        Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures  in US$
        Million for Years 2011 through 2015 (includes corresponding
        Graph/Chart)                                                    III-75

        Table 78: Rest of Europe 10-Year Perspective for  CNS
        Therapeutics by Product Group - Percentage Breakdown of
        Dollar Sales for Anti-Alzheimer's, Anti-Parkinson's,
        Anti-Epilepsy, Pain Management, Anti-Psychotics,
        Anti-Depressants and Other Markets for Years 2003, 2008 &
        2012 (includes corresponding Graph/Chart)                       III-76

  4. Asia-Pacific                                                       III-77
      A.Market Analysis                                                 III-77
        Current & Future Analysis                                       III-77
        An Overview of the Japanese Market                              III-77
         Pain Management Market                                         III-77
        Product Launches/Developments                                   III-77
        Strategic Corporate Developments                                III-78
        Key Players                                                     III-80
      B.Market Analytics                                                III-81
        Table 79: Asia-Pacific Recent Past, Current & Future
        Analysis for CNS Therapeutics by Product Group -
        Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
        Management, Anti-Psychotics, Anti-Depressants and Other
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010  (includes
        corresponding Graph/Chart)                                      III-81

        Table 80: Asia-Pacific Long-term Projections for CNS
        Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2011 through 2015 (includes corresponding
        Graph/Chart)                                                    III-82

        Table 81: Asia-Pacific 10-Year Perspective for CNS
        Therapeutics by Product Group - Percentage Breakdown  of
        Dollar Sales for Anti-Alzheimer's, Anti-Parkinson's,
        Anti-Epilepsy, Pain Management, Anti-Psychotics,
        Anti-Depressants and Other Markets for Years 2003, 2008 &
        2012 (includes corresponding Graph/Chart)                       III-83

  5. Latin America                                                      III-84
       Market Analysis                                                  III-84
        Table 82: Latin American Recent Past, Current & Future
        Analysis for CNS Therapeutics by Product Group -
        Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
        Management, Anti-Psychotics, Anti-Depressants and Other
        Markets Independently Analyzed with Annual Sales Figures in
        US$ Million for Years 2000 through 2010 (includes
        corresponding Graph/Chart)                                      III-84

        Table 83: Latin American Long-term Projections for CNS
        Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures  in US$
        Million for Years 2011 through 2015  (includes corresponding
        Graph/Chart)                                                    III-85

        Table 84: Latin American 10-Year Perspective for CNS
        Therapeutics by Product Group - Percentage Breakdown  of
        Dollar Sales for Anti-Alzheimer's, Anti-Parkinson's,
        Anti-Epilepsy, Pain Management, Anti-Psychotics,
        Anti-Depressants and Other Markets for  Years 2003, 2008 &
        2012 (includes  corresponding Graph/Chart)                      III-86

  6. Rest of World                                                      III-87
      A.Market Analysis                                                 III-87
        Current & Future Analysis                                       III-87
        Strategic Corporate Developments                                III-87
        Key Players                                                     III-88
      B.Market Analytics                                                III-89
        Table 85: Rest of World Recent Past, Current & Future
        Analysis for CNS Therapeutics Product Group -
        Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
        Management, Anti-Psychotics, Anti-Depressants  and Other
        Markets Independently Analyzed with  Annual Sales Figures in
        US$ Million for Years 2000  through 2010 (includes
        corresponding  Graph/Chart)                                     III-89

        Table 86: Rest of World Long-term Projections for CNS
        Therapeutics by Product Group - Anti-Alzheimer's,
        Anti-Parkinson's, Anti-Epilepsy, Pain Management,
        Anti-Psychotics, Anti-Depressants and Other Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2011 through 2015 (includes corresponding
        Graph/Chart)                                                    III-90

        Table 87: Rest of World 10-Year Perspective for CNS
        Therapeutics by Product Group - Percentage Breakdown  of
        Dollar Sales for Anti-Alzheimer's, Anti-Parkinson's,
        Anti-Epilepsy, Pain Management, Anti-Psychotics,
        Anti-Depressants and Other Markets for  Years 2003, 2008 &
        2012 (includes  corresponding Graph/Chart)                      III-91


 IV. COMPETITIVE LANDSCAPE

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