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New PublicationsCNS THERAPEUTICS MCP-1835
A GLOBAL STRATEGIC BUSINESS REPORT
CONTENTS
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-2
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
CNS Disorders I-3
A. Anti-Alzheimer's Drugs I-3
B. Anti-Parkinson's Drugs I-4
C. Anti-Epilepsy Drugs I-4
D. Pain Management Drugs I-4
E. Anti-Psychotics Drugs I-5
(i) Bipolar disorder I-5
(ii) Schizophrenia I-5
F. Anti-Depressants Drugs I-5
G. Others I-6
(i) Attention Deficit Hyperactivity Disorder I-6
(ii) Multiple Sclerosis I-6
(iii) Insomnia I-6
(iv) Restless Legs Syndrome I-7
(v) Anxiety I-7
II. EXECUTIVE SUMMARY
1. Industry Overview II-1
Factors Influencing Demand II-1
The 'Age Factor' II-1
Role of Diagnostic Techniques II-1
Increasing Disease Awareness II-1
Emergent Technologies II-1
Reimbursement Policies II-2
Market Trends and Issues II-2
Booming Therapeutic Opportunities for Neuro-Degenerative
Disorders II-2
Spur in CNS Drug Delivery Technologies II-2
Migraine Market Offers Growth Opportunities to Prophylaxis
Products II-3
Demand for Therapeutic Peptides Spurred by Dearth of
Effective Therapies II-3
Anti-Depressants II-3
Major Trends in the Depression Market II-4
SSRIs are the Preferred Choice Despite Side Effects II-4
Table 1: US Anti-Depressants Market (2004-2006): Sales of
Leading Drug Brands - Zoloft, Effexor ER, Lexapro,
Wellbutrin, Paxil, Celexa and Prozac (In US$M) (includes
corresponding Graph/Chart) II-5
Table 2: Leading Brands in European Anti-Depressants Market
(2005): Percentage Breakdown by Value Sales for Effexor,
Zoloft, Paxil, Cipralex, Wellbutrin, Citalopram, Prozac,
Remeron and Others (includes corresponding Graph/Chart) II-5
Attention Deficit Hyperactivity Disorder (ADHD) II-5
Table 3: Worldwide ADHD Market (2005): Sales of Leading
Drug Brands -Concerta, Adderall/ Adderall ER and Strattera
(includes corresponding Graph/Chart) II-6
Major Trends in the ADHD Market: II-6
Anti-Psychotics Market II-6
Restrictions on Promotion Hamper Market Prospects II-7
Table 4: Worldwide Atypical Anti-Psychotics Market (2004 &
2005): Sales of Leading Drug Brands - Zyprexa, Risperdal,
Seroquel, Abilify and Zeldox (includes corresponding
Graph/Chart) II-7
Table 5: Leading Brands in Worldwide Anti-Psychotics Market
(Bipolar Disorder) (2003-2005): Percentage Breakdown by
Value Sales for Zyprexa, Risperdal, Seroquel, Abilify and
Others (includes corresponding Graph/Chart) II-8
Table 6: Leading Brands in US Anti-Psychotics Market
(2004-2006): Percentage Breakdown by Value Sales for
Zyprexa, Risperdal, Seroquel, Depakote/ER, Abilify,
Lamictal/XR, Geodon and Others (includes corresponding
Graph/Chart) II-9
Table 7: Leading Brands in European Atypical
Anti-Psychotics Market (2004): Percentage Breakdown by
Value Sales for Zyprexa, Risperdal/ Risperdal CONSTA,
Seroquel, Solian, Risperidone, Geodon and Others (includes
corresponding Graph/Chart) II-10
Insomnia II-10
Anti-Insomnia Drugs from Corporate Giants Flood the Sleep
Market II-10
Neuropathic Pain II-10
Table 8: Leading Players in the US Pain Management Market
(2005): Percentage Breakdown by Value Sales for J&J, Endo
Pharmaceuticals, Purdue Pharma, Cephalon, King/Ligand and
Others (includes corresponding Graph/Chart) II-11
Patent Expiry of Leading CNS Drugs: 2005-2017 II-11
2. Global Market Analysis II-12
By Region II-12
By Segment II-12
3. CNS Disorders - An Introduction II-13
Definition II-13
Central Nervous System II-13
Mortality Threat of CNS Disorders II-13
Science of NMDA Receptors and its Disease Significance II-13
Major CNS Disorders: II-14
Alzheimer's Disease II-14
Alzheimer's Affect on Brain II-14
Causes for Alzheimer's II-15
Who Are at Risk? II-15
Prevalence of Alzheimer's Disease II-16
Table 9: Incidence of Alzheimer's Disorder in Major US
States: 2000-2025 (includes corresponding Graph/Chart) II-16
Table 10: Leading Brands in the US Anti-Alzheimer's Market
(2004-2005): Percentage Breakdown by Value Sales for
Aricept, Namenda, Razadyne/ Razadyne ER and Exelon
(includes corresponding Graph/Chart) II-17
Diagnosis of Alzheimer's II-17
Treatment for Alzheimer's II-17
Parkinson's Disease II-18
Table 11: Leading Brands in Worldwide Anti-Parkinson's
Disease Market (2005): Percentage Breakdown by Value Sales
for Mirapex, Requip, Cabaser, Madopar, Stalevo and Others
(includes corresponding Graph/Chart) II-18
Prevalence of Parkinson's II-19
Symptom of Parkinson's II-19
Causes of Parkinson's II-19
Parkinson's Diagnosis II-20
Therapies for Parkinson's II-20
Surgery: The Last Option II-20
Epilepsy II-21
Table 12: Worldwide Epilepsy Market (2004-2005): Sales of
Leading Drug Brands - Topamax, Lamictal, Depakote, Neurontin
and Trileptal (In US$ Million) (includes corresponding
Graph/Chart) II-21
Therapies for Epilepsy II-21
Pain Management II-22
Debilitating Effects of Pain II-23
Types of Pain II-23
Acute Pain II-23
Chronic Pain II-23
Migraine II-23
Neuropathic Pain II-23
Nociceptive Pain II-24
Pain Management Therapies II-24
Bipolar Disorder II-24
Symptoms of Bipolar Disorder II-24
Therapies for Bipolar Disorder II-25
Schizophrenia II-25
Symptoms of Schizophrenia II-25
Therapies for Schizophrenia II-25
Depression II-25
Prevalence of Depression II-26
Causes of Depression II-26
Types of Depressive Disorders II-26
Available Treatment II-26
Tricyclic Antidepressants II-27
Monoamine Oxidase Inhibitors II-27
Lithium Salts II-27
Working of Antidepressants II-27
Ranking of Antidepressants in Terms of Efficacy II-27
Types of Antidepressants II-28
NMDA Receptor Antagonists II-28
NMDA Receptor (NMDAR) II-28
NMDA Receptor Agonists II-28
Acetylcholinesterase Inhibitors II-28
Selective Serotonin Reuptake Inhibitors (SSRIs) II-29
Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) II-29
Others Common CNS Disorders II-30
Attention Deficit Hyperactivity Disorder II-30
Consequences of ADHD II-30
What Leads to ADHD? II-31
Treating ADHD II-31
Multiple Sclerosis (MS) II-31
Types of Multiple Sclerosis II-32
Prevalence of MS II-32
Causes of MS II-32
Myths Surrounding Multiple Sclerosis II-32
Symptoms of MS II-33
Diagnosis of MS II-33
Therapies for MS II-33
Insomnia II-33
Prevalence of Insomnia II-33
Therapies for Insomnia II-34
Restless Legs Syndrome II-34
Anxiety II-34
4. Overview of Select CNS Drugs II-35
Anti-Alzheimer's Drugs II-35
Aricept II-35
Exelon II-35
Reminyl II-35
Ebixa II-35
Namenda II-35
Anti-Parkinson's Drugs II-36
Levodopa II-36
Dopamine Agonists II-36
Mirapex II-36
Requip II-36
Anti-Epilepsy Drugs II-36
Carbamazepine II-36
Phenytoin II-36
Lamictal II-37
Depakote II-37
Neurotonin II-37
Pain Management II-37
Duragesic II-37
Metabotropic Glutamate Receptors (mGluRs) II-37
Anti-Psychotics II-38
Zyprexa II-38
Seroquel II-38
Abilify II-38
Clozaril II-38
Antidepressants Drugs II-38
Zoloft (Sertraline) II-38
Prozac (Fluoxetine) II-39
Effexor (Venlafaxine) II-39
Paxil II-39
Wellbutrin (Bupropion) II-39
Attention Deficit Hyperactivity Disorder (ADHD) II-39
Concerta II-39
Strattera II-40
Adderall II-40
Insomnia II-40
Estorra II-40
Lunesta II-40
5. Research & Development II-41
AstraZeneca, NPS Develop mGluRs for CNS Disorders II-41
High Efavirenz Plasma Levels in HIV Patients Could Result in
CNS Toxicity II-41
Adenoviral Gene Therapy May Damage CNS II-41
Role of B Cells in Damaging Nerve Fibers II-41
Oral Administration of Antibodies Restrict Attacks in MS II-42
Country of Birth/Dwelling Influences Risk of Multiple Sclerosis II-42
Levetiracetam is Effective in Epilepsy Prevention II-42
Nicotine Guards Against Parkinson's-Like Disease II-42
Parkinson's Drugs May Influence Addictions II-43
Dopamine Induces Sleep and Brain Activity II-43
Researchers Link Obesity to Dementia II-43
High Folate Consumption Mitigates Risks to Alzheimer's Disease II-43
Consistent Depression Treatment Likely to Prevent Relapse II-43
Animal Research Model Highlights Difficulties of Depression
Syndrome II-43
Hypnion Announces Encouraging Results for HY10275 II-44
Antihistamine Effective In Mitigating Alzheimer's Disorder II-44
Novartis' Fingolimod Alleviate MS Activity II-44
Lundbeck Initiates Trials of its Novel Anti-Psychotic Drug II-44
Cara Develops CR665 for Pain Management II-44
Gepirone ER of Fabre-Kramer Effective in Depression II-44
Biogen Idec Discovers Molecule for Treatment of CNS Disorders II-45
Teva Claims Copaxone as the Ultimate in Treating MS II-45
Biogen Idec and Elan Corp. Conclude Safety Evaluation of Tysabri II-45
Cognetix Files Provisional Patent for Screening Methods of
CGX-1160 II-45
NeuroSearch's NS2330 Fail to Meet Efficacy Standards in Trials II-45
Medtronic Undertakes Trials to Study Treatment Resistant
Depression II-45
National MS Society to Initiate Efforts to Identify MS
Influencing Genetics II-45
Academic Data Supports COMT Inhibitors Performance in Parkinson's II-46
MS Ireland Supports Return of Tysabri II-46
Cigarette Smoking Increases Risks of Multiple Sclerosis II-46
Study of Parkinson's Incidence in Zambia, Russia and Uzbekistan II-46
Encouraging Developments in Animal Model of Parkinson's Disease II-46
6. Product Innovations/Introductions II-47
Biogen and Elan Introduces Tysabri in Europe II-47
Medtronic Launches Activa for Parkinson's Disease II-47
Tysabri Obtains Canadian Approval For Multiple Sclerosis II-47
Lundbeck Unveils Serdolect Available in Estonia II-47
OPC, Bristol-Myers Unveil Abilify Discmelt II-47
OPC Introduces Anti-Psychotic Drug Abilify in Japan II-47
FDA Approves Novartis' Exelon for Parkinson's II-48
Ono Pharmaceutical, Novartis Develops Transdermal Patch for
Alzheimer's II-48
Zydus Cadila Drugs Flood the French Pharmaceutical Market II-48
Schwarz Pharma Develops Anti-Parkinson's Drug II-48
Azilect Enters European Market II-48
Lilly Launches Therapy for Bipolar Disorder II-48
7. Recent Industry Activity II-49
P1vital Creates Global Consortium to Develop CNS Experimental
Medicine II-49
Neurobiological Tech Teams Up with Buck Institute II-49
ExonHit Therapeutics and Allergan Ink Contract to Develop CNS
Agents II-49
NeuroSearch Commences Clinical Phase I study with NSD-788 in
France II-49
Abilify Meets CHMP Standards II-49
UCB Receives Recommendation for Approval for Neupro II-49
Schering-Plough Acquires Organon II-50
UCB Launches Neupro in the US II-50
GlaxoSmithKline Forms Alliance with Targacept II-50
GSK Teams-Up with Sepracor for Commercializing Lunivia II-50
US FDA Rebut NDA for bifeprunox II-51
Medtronic and Alnylam Extend their Drug-Device Collaboration II-51
Neuren Takes Over Hamilton II-51
Roche Forms Partnership with Synosis Therapeutics to Evaluate
Five CNS Compounds II-51
NeuroSearch Starts Clinical Phase I Study with ACR343 in Sweden II-51
Lundbeck to Promote Circadin in Europe II-51
Sepracor Inks Partnership with Eisai to Develop and Market
Lunesta in Japan II-52
Neurologix Obtains License of Gene Therapy Component II-52
Prestwick Raises Fund to Finance CNS Projects II-52
Kyowa Inks Agreement with Britannia II-52
China Aoxing Pharmaceutical Receives Product Approvals II-53
China Aoxing Acquires Hebei Aoxing II-53
AlphaRx Partners with Israel based PharmSeed Ltd II-53
Nippon Boehringer Markets CNS Drugs on Portals II-53
FDA Approves Tysabri for treating MS II-53
CeNeS Acquires Certain IP Rights from ALZA II-53
Belgium based UCB Acquires Schwarz Pharma II-54
Axaron and LION Bioscience Establish New Company II-54
Ceregene Obtains Grant for Phase II Trial II-54
Shire Obtains Anti-Epileptic Drug License from Yissum II-54
TorreyPines and Axonyx Conclude Merger Operations II-54
VistaGen Enters Into Strategic Partnership with Cato BioVentures II-54
Organon Announces Partnership with BrainCells II-55
Alkermes Inks Licensing Agreement with Rensselaer II-55
FDA Approves SEROQUEL Therapy for Bipolar Indication II-55
Boehringer Ingelheim, Eli Lilly Modify Agreement Terms II-55
Boston Life Sciences Signs Licensing Agreement with Children's
Hospital II-55
CeNeS, Tripos Extend Research Collaboration II-55
CeNeS Partners Ergomed for CNS 5161 Phase II Clinical Trial II-56
CeNeS' Short-Acting Sedative Obtains Patent II-56
Takeda and Cephalon Collaborate Over Provigil II-56
Eli Lilly Files sNDA for Cymbalta II-56
GlaxoSmithKline Obtains FDA Approval for Lamictal II-56
Serono Acquires Safinamide License from Neuron II-56
Neurocrine Files NDA for Anti-Insomnia Drug Indiplon II-56
Novartis Inks Agreement with Servier, Idenix II-57
NPS Extends Alliance with AstraZeneca II-57
Pfizer's Lyrica Receives Approval for Neuropathic Pain II-57
Schwarz Pharma Receives FDA Approval of Neupro II-57
Teva's Azilect tablets Approved in Canada II-57
Teva and Eisei Terminate Joint Marketing Alliance II-57
FDA Approves Teva's Azilect for Parkinson's Disorder II-58
UCB's Keppra Obtains FDA Approval to Treat Epilepsy II-58
Wyeth, Solvay Pharmaceuticals Files NDA for Schizophrenia Drug II-58
D-Pharm Licenses DP-b99 Drug to Yungjin II-58
Eli Lilly, Suven Collaborate Over CNS Therapies II-58
IVAX to Develop Oral Therapy for Multiple Sclerosis II-58
Thomson Takes Over Cipher's Business Unit II-58
CLL Pharma Acquires Synt: em SA II-59
Ranbaxy Acquires Advent's Subsidiary II-59
Shire Receives Approval of Daytrana for Treating ADHD Disorder II-59
Shire Inks Marketing Agreement with New River II-59
Acadia and Sepracor in a Collaborative R&D Deal II-59
Ablynx Partners with National Research Council of Canada II-59
Bristol Myers and Albany Sign Licensing Agreement II-60
Andara Secures Licenses to Purdue's Treatment Alternatives II-60
Otsuka Ties Up with Galenea to Develop CNS drugs II-60
Novartis Inks Distribution Agreement with Alfresa Pharma II-60
Dainippon Commences Operations of New Facility II-60
Ranbaxy Purchases Generic Product Line of Efarmes II-60
Novasite Takes Over PsyCheNomicS II-61
Organon Returns Gepirone ER Rights to Fabre-Kramer II-61
Teva Expands Operations in India II-61
Neurologix Acquires License to Alzheimer's Treating Gene II-61
Meda Takes Over Viatris II-61
Evotec Acquires Majority Stake in Evotec Neurosciences II-61
IVAX Merges with Teva Pharmaceutical II-62
Wyeth Files NDA for Anti-Depressant Drug DVS-233 II-62
Schwarz Pharma Acquires Rights of Rotigotine II-62
Shire Submits NDA for Two ADHD Drugs II-62
Takeda and Paradigm Collaborate to Develop CNS Therapies II-62
Sanofi's Ambien CR to Induce and Maintain Sleep in the US II-62
NeuroSearch Initiates Phase I Clinical Study of ABT- 894 II-62
NeuroSearch Receives Euro 10 Million as Milestone Payments for
NS2359 II-62
FDA Approves Depakote ER for Bipolar Disorder Treatment II-63
Alkermes Receives Approval for Risperdal Consta in Italy II-63
AstraZeneca Signs Research Collaboration Deal with Targacept II-63
Cymbalta / Xeristar Treatment Approved for Depression in Europe II-63
FDA Grants SPA Status to Boston Life's Altropane II-63
Sumitomo Merges with Dainippon II-63
Cipralex Therapy Extended to GAD in Europe II-63
Johnson & Johnson Submits Paliperidone ER for NDA II-64
Spectrum Acquires License of CNS Cancer Therapeutic Drug II-64
Multiple Sclerosis Drug Tysabri Pulled Off Market II-64
Roche Partners with GE Healthcare II-64
New River to Develop Pain Management Therapies II-64
Elekta Takes Over IMPAC Medical Systems II-64
Eli Lilly Acquires Merck's Product Compound for Insomnia II-64
Prestwick Raises Funds to Develop CNS Therapies II-65
Aspect Medical Acquires Exclusive Rights to Cordance Technology II-65
Bristol-Myers Pulls Out Serzone from the US Market II-65
Paladin Inks Agreement with Ovation II-65
Acorda Raises Funds For Therapy Development II-65
Wyeth Sells Indiplon Ownership Rights to Neurocrine II-65
Micrologix Takes Over Mitokor II-66
Sanofi Merges with Aventis to Form a New Company II-66
VistaGen Takes Over Artemis II-66
Neuro Bioscience Acquires Majority Stake in CLL Pharma II-66
Tiger Brands Acquires Pfizer's Subsidiary II-66
Pfizer Acquires Asenapine License from Organon II-66
8. Focus on Select Global Players II-67
Abbott Laboratories (USA) II-67
Alkermes, Inc. (USA) II-67
AstraZeneca Plc (UK) II-67
Boehringer Ingelheim GmbH (Germany) II-67
Bristol-Myers Squibb (USA) II-68
CeNeS Pharmaceuticals Plc (UK) II-68
Cephalon, Inc. (USA) II-68
Dainippon Sumitomo Pharma Co., Ltd. (Japan) II-69
Elan Corporation Plc (Ireland) II-69
Eli Lilly and Co. (USA) II-69
Fabre-Kramer Pharmaceuticals, Inc. (USA) II-70
F. Hoffmann-La Roche Ltd. (Switzerland) II-70
Forest Laboratories, Inc. (USA) II-70
GlaxoSmithKline (UK) II-70
H. Lundbeck A/S (Denmark) II-71
Johnson & Johnson (USA) II-71
Janssen Pharmaceutica N.V. (Belgium) II-71
Janssen-Cilag (Switzerland) II-71
Merck & Co, Inc. (USA) II-71
Neurocrine Biosciences, Inc. (USA) II-72
Novartis AG (Switzerland) II-72
Sandoz International GmbH (Germany) II-72
Organon N.V. (The Netherlands) II-73
Ortho-McNeil Neurologics, Inc. (USA) II-73
Otsuka Pharmaceutical Co., Ltd. (Japan) II-73
Pfizer, Inc. (USA) II-73
Sanofi-Aventis (France) II-74
Schwarz Pharma AG (Germany) II-74
Sepracor, Inc. (USA) II-74
Shire Plc (UK) II-74
Solvay Pharmaceuticals S.A. (France) II-75
Takeda Pharmaceutical Co., Ltd. (Japan) II-75
Teva Pharmaceutical Industries Ltd. (Israel) II-75
UCB S.A. (Belgium) II-75
Wyeth (USA) II-76
9. Global Market Perspective II-77
Table 13: World Recent Past, Current & Future Analysis for CNS
Therapeutics by Geographic Region - USA, Canada, Europe,
Asia-Pacific (including Japan), Latin America and Rest of
World Markets Independently Analyzed with Annual Sales Figures
in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-77
Table 14: World Long-term Projections for CNS Therapeutics by
Geographic Region - USA, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-78
Table 15: World 10-Year Perspective for CNS Therapeutics by
Geographic Region - Percentage Breakdown of Dollar Sales for
USA, Canada, Europe, Asia-Pacific (including Japan), Latin
America and Rest of World Markets for Years 2003, 2008 & 2012
(includes corresponding Graph/Chart) II-79
Table 16: World Recent Past, Current & Future Analysis for
Anti-Alzheimer's Drugs by Geographic Region - USA, Canada,
Europe, Asia-Pacific (including Japan), Latin America and
Rest of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-80
Table 17: World Long-term Projections for Anti-Alzheimer's
Drugs by Geographic Region - USA, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-81
Table 18: World 10-Year Perspective for Anti-Alzheimer's Drugs
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Europe, Asia-Pacific (including Japan),
Latin America and Rest of World Markets for Years 2003, 2008
& 2012 (includes corresponding Graph/Chart) II-82
Table 19: World Recent Past, Current & Future Analysis for
Anti-Parkinson's Drugs by Geographic Region - USA, Canada,
Europe, Asia-Pacific (including Japan), Latin America and
Rest of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-83
Table 20: World Long-term Projections for Anti-Parkinson's
Drugs by Geographic Region - USA, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-84
Table 21: World 10-Year Perspective for Anti-Parkinson's Drugs
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Europe, Asia-Pacific (including Japan), Latin
America and Rest of World Markets for Years 2003, 2008 & 2012
(includes corresponding Graph/Chart) II-85
Table 22: World Recent Past, Current & Future Analysis for
Anti-Epilepsy Drugs by Geographic Region - USA, Canada,
Europe, Asia-Pacific (including Japan), Latin America and
Rest of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-86
Table 23: World Long-term Projections for Anti-Epilepsy Drugs
by Geographic Region - USA, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-87
Table 24: World 10-Year Perspective for Anti-Epilepsy Drugs
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Europe, Asia-Pacific (including Japan), Latin
America and Rest of World Markets for Years 2003, 2008 & 2012
(includes corresponding Graph/Chart) II-88
Table 25: World Recent Past, Current & Future Analysis for
Pain Management Drugs by Geographic Region - USA, Canada,
Europe, Asia-Pacific (including Japan), Latin America and
Rest of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-89
Table 26: World Long-term Projections for Pain Management
Drugs by Geographic Region - USA, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-90
Table 27: World 10-Year Perspective for Pain Management Drugs
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Europe, Asia-Pacific (including Japan),
Latin America and Rest of World Markets for Years 2003, 2008
& 2012 (includes corresponding Graph/Chart) II-91
Table 28: World Recent Past, Current & Future Analysis for
Anti-Psychotics Drugs by Geographic Region - USA, Canada,
Europe, Asia-Pacific (including Japan), Latin America and
Rest of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-92
Table 29: World Long-term Projections for Anti-Psychotics
Drugs by Geographic Region - USA, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-93
Table 30: World 10-Year Perspective for Anti-Psychotics Drugs
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Europe, Asia-Pacific (including Japan), Latin
America and Rest of World Markets for Years 2003, 2008 & 2012
(includes corresponding Graph/Chart) II-94
Table 31: World Recent Past, Current & Future Analysis for
Anti-Depressants Drugs by Geographic Region - USA, Canada,
Europe, Asia-Pacific (including Japan), Latin America and
Rest of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-95
Table 32: World Long-term Projections for Anti-Depressants
Drugs by Geographic Region - USA, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-96
Table 33: World 10-Year Perspective for Anti-Depressants Drugs
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Europe, Asia-Pacific (including Japan),
Latin America and Rest of World Markets for Years 2003, 2008
& 2012 (includes corresponding Graph/Chart) II-97
Table 34: World Recent Past, Current & Future Analysis for
Other Drugs by Geographic Region - USA, Canada, Europe,
Asia-Pacific (including Japan), Latin America and Rest of
World Markets Independently Analyzed with Annual Sales Figures
in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-98
Table 35: World Long-term Projections for Other Drugs by
Geographic Region - USA, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-99
Table 36: World 10-Year Perspective for Other Drugs by
Geographic Region - Percentage Breakdown of Dollar Sales for
USA, Canada, Europe, Asia-Pacific (including Japan), Latin
America and Rest of World Markets for Years 2003, 2008 & 2012
(includes corresponding Graph/Chart) II-100
III. MARKET
1. The United States III-1
A.Market Analysis III-1
Current & Future Analysis III-1
Cost Implications of CNS Disorders III-1
Alzheimer's Market III-1
Table 37: Incidence of Alzheimer's Disorder in Major US
States: 2000-2025 (includes corresponding Graph/Chart) III-2
Anti-Alzheimer's Drugs Approved for Use in the Past III-2
Table 38: Leading Brands in the US Anti-Alzheimer's Market
(2004 & 2005): Percentage Breakdown by Value Sales for
Aricept, Namenda, Razadyne / Razadyne ER and Exelon
(includes corresponding Graph/Chart) III-3
Cost of Care to AD Patient III-3
Clinical Pipeline III-3
Anti-Psychotics III-3
Growth Dampeners III-4
Clinical Pipeline III-4
Table 39: Leading Brands in US Anti-Psychotics Market
(2004-2006): Percentage Breakdown by Value Sales for
Zyprexa, Risperdal, Seroquel, Depakote/ER, Abilify,
Lamictal/XR, Geodon and Others (includes corresponding
Graph/Chart) III-5
Table 40: Leading Brands in US Atypical Anti-Psychotics
Market (2004, 2006 & 2008): Percentage Breakdown by Value
Sales for Zyprexa, Risperdal/ Risperdal CONSTA, Seroquel,
Abilify, Geodon and Others (includes corresponding
Graph/Chart) III-5
Antidepressants III-6
Antidepressants to Feature Black-Box Warnings III-6
Antidepressant Consumption Falls Among Children and
Adolescents III-6
Table 41: US Anti-Depressants Market (2004-2006): Sales of
Leading Drug Brands - Zoloft, Effexor ER, Lexapro,
Wellbutrin, Paxil, Celexa and Prozac (includes
corresponding Graph/Chart) III-6
Multiple Sclerosis III-7
Table 42: Leading Anti-Multiple Sclerosis Drugs in the US
(2004): Percentage Breakdown of Value Sales for Avonex,
Copaxone, Rebif and Betaseron (includes corresponding
Graph/Chart) III-7
Insomnia Market III-7
Rising Consumption of ADHD Drugs Combat Safety Concerns III-7
Table 43: US ADHD Market (2005): Percentage Breakdown of
Sales by Leading Brands - Concerta, Strattera, Ritalin,
Metadate, Focalin XR and Others (includes corresponding
Graph/Chart) III-8
Unmet Medical Needs in Neuropathic Pain Offer Growth Prospects III-8
Table 44: Leading Players in the US Pain Management Market
(2005-2007): Percentage Breakdown by Value Sales for J&J,
ENDO, Purdue, Cephalon, King/Ligand and Others (includes
corresponding Graph/Chart) III-8
CNS Tuberculosis Raises its Ugly Head III-9
Product Launches/Developments III-9
Strategic Corporate Developments III-10
Key Players III-20
B.Market Analytics III-26
Table 45: US Recent Past, Current & Future Analysis for CNS
Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2000 through 2010 (includes corresponding
Graph/Chart) III-26
Table 46: US Long-term Projections for CNS Therapeutics by
Product Group - Anti-Alzheimer's, Anti-Parkinson's,
Anti-Epilepsy, Pain Management, Anti-Psychotics,
Anti-Depressants and Other Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-27
Table 47: US 10-Year Perspective for CNS Therapeutics by
Product Group - Percentage Breakdown of Dollar Sales for
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-28
2. Canada III-29
A.Market Analysis III-29
Current & Future Analysis III-29
Facts & Figures III-29
Strategic Corporate Developments III-29
Neurochem, Inc. - A Major Player III-30
B.Market Analytics III-31
Table 48: Canadian Recent Past, Current & Future Analysis
for CNS Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2000 through 2010 (includes corresponding
Graph/Chart) III-31
Table 49: Canadian Long-term Projections for CNS
Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-32
Table 50: Canadian 10-Year Perspective for CNS Therapeutics
by Product Group - Percentage Breakdown of Dollar Sales for
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets for Years 2003, 2008 & 2012 (includes
corresponding Graph/Chart) III-33
3. Europe III-34
A.Market Analysis III-34
Current & Future Analysis III-34
By Region III-34
By Product Segment III-34
Anti-Psychotics Market III-34
Table 51: European Anti-Psychotics Market (2002-2006):
Percentage Breakdown of Revenues by Product Class -
Atypical Anti-Psychotics Drugs and Traditional
Anti-Psychotics Drugs (includes corresponding Graph/Chart) III-34
Table 52: Leading Brands in European Atypical
Anti-Psychotics Market (2004): Percentage Breakdown by
Value Sales for Zyprexa, Risperdal/ Risperdal CONSTA,
Seroquel, Solian, Risperidone, Geodon and Others (includes
corresponding Graph/Chart) III-35
European CNS Market Offers Untapped Opportunities III-35
Competitive Scenario of CNS Drug Market III-35
Challenges Faced by the Antidepressants Market III-35
Table 53: Leading Brands in European Anti-Depressants
Market (2005): Percentage Breakdown by Value Sales for
Effexor, Zoloft, Paxil, Cipralex, Wellbutrin, Citalopram,
Prozac, Remeron and Others (includes corresponding
Graph/Chart) III-36
Table 54: European Anti-Depressants Market (2004-2006):
Percentage Breakdown of Revenues by Segment - SSRI, SNRI
and Others (includes corresponding Graph/Chart) III-36
Product Launches/Developments III-36
Strategic Corporate Developments III-37
Key Players III-42
B.Market Analytics III-47
Table 55: European Recent Past, Current & Future Analysis
for CNS Therapeutics by Geographic Region - France, Germany,
Italy, UK, Spain and Rest of Europe Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-47
Table 56: European Long-term Projections for CNS
Therapeutics by Geographic Region - France, Germany, Italy,
UK, Spain and Rest of Europe Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-48
Table 57: European Recent Past, Current & Future Analysis
for CNS Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2000 through 2010 (includes corresponding
Graph/Chart) III-49
Table 58: European Long-term Projections for CNS
Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-50
Table 59: European 10-Year Perspective for CNS Therapeutics
by Geographic Region - Percentage Breakdown of Dollar Sales
for France, Germany, Italy, UK, Spain and Rest of Europe
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-51
Table 60: European 10-Year Perspective for CNS Therapeutics
by Product Group - Percentage Breakdown of Dollar Sales for
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets for Years 2003, 2008 & 2012 (includes
corresponding Graph/Chart) III-52
3a. France III-53
A.Market Analysis III-53
Current & Future Analysis III-53
Healthcare System in France III-53
B.Market Analytics III-54
Table 61: French Recent Past, Current & Future Analysis for
CNS Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2000 through 2010 (includes corresponding
Graph/Chart) III-54
Table 62: French Long-term Projections for CNS Therapeutics
by Product Group - Anti-Alzheimer's, Anti-Parkinson's,
Anti-Epilepsy, Pain Management, Anti-Psychotics,
Anti-Depressants and Other Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-55
Table 63: French 10-Year Perspective for CNS Therapeutics
by Product Group - Percentage Breakdown of Dollar Sales for
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-56
3b. Germany III-57
A.Market Analysis III-57
Current & Future Analysis III-57
Healthcare System in Germany III-57
Reimbursement Policy III-57
B.Market Analytics III-58
Table 64: German Recent Past, Current & Future Analysis for
CNS Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2000 through 2010 (includes corresponding
Graph/Chart) III-58
Table 65: German Long-term Projections for CNS Therapeutics
by Product Group - Anti-Alzheimer's, Anti-Parkinson's,
Anti-Epilepsy, Pain Management, Anti-Psychotics,
Anti-Depressants and Other Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-59
Table 66: German 10-Year Perspective for CNS Therapeutics by
Product Group - Percentage Breakdown of Dollar Sales for
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets for Years 2003, 2008 & 2012 (includes
corresponding Graph/Chart) III-60
3c. Italy III-61
A.Market Analysis III-61
Current & Future Analysis III-61
Healthcare System in Italy III-61
Market Snapshots III-61
B.Market Analytics III-62
Table 67: Italian Recent Past, Current & Future Analysis for
CNS Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2000 through 2010 (includes corresponding
Graph/Chart) III-62
Table 68: Italian Long-term Projections for CNS Therapeutics
by Product Group - Anti-Alzheimer's, Anti-Parkinson's,
Anti-Epilepsy, Pain Management, Anti-Psychotics,
Anti-Depressants and Other Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-63
Table 69: Italian 10-Year Perspective for CNS Therapeutics
by Product Group - Percentage Breakdown of Dollar Sales for
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-64
3d. The United Kingdom III-65
A.Market Analysis III-65
Current & Future Analysis III-65
Healthcare System in the UK III-65
NICE Recommendations on CNS Therapeutics III-65
B.Market Analytics III-66
Table 70: UK Recent Past, Current & Future Analysis for CNS
Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2000 through 2010 (includes corresponding
Graph/Chart) III-66
Table 71: UK Long-term Projections for CNS Therapeutics by
Product Group - Anti-Alzheimer's, Anti-Parkinson's,
Anti-Epilepsy, Pain Management, Anti-Psychotics,
Anti-Depressants and Other Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-67
Table 72: UK 10-Year Perspective for CNS Therapeutics by
Product Group - Percentage Breakdown of Dollar Sales for
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-68
3e. Spain III-69
A.Market Analysis III-69
Current & Future Analysis III-69
Healthcare System in Spain III-69
B.Market Analytics III-70
Table 73: Spanish Recent Past, Current & Future Analysis for
CNS Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2000 through 2010 (includes corresponding
Graph/Chart) III-70
Table 74: Spanish Long-term Projections for CNS Therapeutics
by Product Group - Anti-Alzheimer's, Anti-Parkinson's,
Anti-Epilepsy, Pain Management, Anti-Psychotics,
Anti-Depressants and Other Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-71
Table 75: Spanish 10-Year Perspective for CNS Therapeutics
by Product Group - Percentage Breakdown of Dollar Sales for
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets for Years 2003, 2008 & 2012 (includes
corresponding Graph/Chart) III-72
3f. Rest of Europe III-73
A.Market Analysis III-73
Current & Future Analysis III-73
Overview of Select Markets III-73
Belgium III-73
Finland III-73
Scandinavia III-73
Sweden III-74
The Netherlands III-74
B.Market Analytics III-74
Table 76: Rest of Europe Recent Past, Current & Future
Analysis CNS Therapeutics by Product Group -
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-74
Table 77: Rest of Europe Long-term Projections for CNS
Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-75
Table 78: Rest of Europe 10-Year Perspective for CNS
Therapeutics by Product Group - Percentage Breakdown of
Dollar Sales for Anti-Alzheimer's, Anti-Parkinson's,
Anti-Epilepsy, Pain Management, Anti-Psychotics,
Anti-Depressants and Other Markets for Years 2003, 2008 &
2012 (includes corresponding Graph/Chart) III-76
4. Asia-Pacific III-77
A.Market Analysis III-77
Current & Future Analysis III-77
An Overview of the Japanese Market III-77
Pain Management Market III-77
Product Launches/Developments III-77
Strategic Corporate Developments III-78
Key Players III-80
B.Market Analytics III-81
Table 79: Asia-Pacific Recent Past, Current & Future
Analysis for CNS Therapeutics by Product Group -
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-81
Table 80: Asia-Pacific Long-term Projections for CNS
Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-82
Table 81: Asia-Pacific 10-Year Perspective for CNS
Therapeutics by Product Group - Percentage Breakdown of
Dollar Sales for Anti-Alzheimer's, Anti-Parkinson's,
Anti-Epilepsy, Pain Management, Anti-Psychotics,
Anti-Depressants and Other Markets for Years 2003, 2008 &
2012 (includes corresponding Graph/Chart) III-83
5. Latin America III-84
Market Analysis III-84
Table 82: Latin American Recent Past, Current & Future
Analysis for CNS Therapeutics by Product Group -
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-84
Table 83: Latin American Long-term Projections for CNS
Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-85
Table 84: Latin American 10-Year Perspective for CNS
Therapeutics by Product Group - Percentage Breakdown of
Dollar Sales for Anti-Alzheimer's, Anti-Parkinson's,
Anti-Epilepsy, Pain Management, Anti-Psychotics,
Anti-Depressants and Other Markets for Years 2003, 2008 &
2012 (includes corresponding Graph/Chart) III-86
6. Rest of World III-87
A.Market Analysis III-87
Current & Future Analysis III-87
Strategic Corporate Developments III-87
Key Players III-88
B.Market Analytics III-89
Table 85: Rest of World Recent Past, Current & Future
Analysis for CNS Therapeutics Product Group -
Anti-Alzheimer's, Anti-Parkinson's, Anti-Epilepsy, Pain
Management, Anti-Psychotics, Anti-Depressants and Other
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-89
Table 86: Rest of World Long-term Projections for CNS
Therapeutics by Product Group - Anti-Alzheimer's,
Anti-Parkinson's, Anti-Epilepsy, Pain Management,
Anti-Psychotics, Anti-Depressants and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-90
Table 87: Rest of World 10-Year Perspective for CNS
Therapeutics by Product Group - Percentage Breakdown of
Dollar Sales for Anti-Alzheimer's, Anti-Parkinson's,
Anti-Epilepsy, Pain Management, Anti-Psychotics,
Anti-Depressants and Other Markets for Years 2003, 2008 &
2012 (includes corresponding Graph/Chart) III-91
IV. COMPETITIVE LANDSCAPE
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