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This report analyzes the worldwide markets for Gene Amplification Technologies in US$ Million by the following Product segments: Polymerase Chain Reaction, and Other Gene Amplification Technologies. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2007 through 2015. Also, a seven-year historic analysis is provided for these markets.The report profiles 91 companies including many key and niche players such as Abbott Laboratories, Becton, Dickinson and Company, bioMerieux, Bio-Rad Laboratories, Cepheid, Life Technologies Corp., QIAGEN N.V, Roche Diagnostics, Rubicon Genomics, and Takara Bio, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.
TABLE OF CONTENTS
GENE AMPLIFICATION TECHNOLOGIES MCP-1102
A GLOBAL STRATEGIC BUSINESS REPORT
CONTENTS
1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS 1
Study Reliability and Reporting Limitations 1
Disclaimers 2
Data Interpretation & Reporting Level 2
Quantitative Techniques & Analytics 3
Product Definitions and Scope of Study 3
Definitions 3
Polymerase Chain Reaction 3
Other Gene Amplification Technologies 3
2. INDUSTRY OVERVIEW 4
PCR Dominates Amplification Technologies 4
Miniaturization - The Next Big Focus 4
Critical in Diagnostic Procedures 5
Leading Players 5
3. TECHNOLOGY OVERVIEW 6
Definition of Gene Amplification 6
Target vs. Signal Amplification 6
Available Types of Gene Amplification Technologies 6
Polymerase Chain Reaction 6
Reagents and Equipment required for PCR 7
Reaction Steps 7
Denaturation 7
Annealing 7
Extension 7
Detection of Amplified Product/DNA 8
(Q&Q) PCR 8
Reverse Transcriptase PCR (RT-PCR) 9
Alternative Technologies to PCR 9
OmniPlex 9
Strand Displacement Amplification 10
Ligase Chain Reaction 10
LCR Involves a Cyclic Two-Step Reaction 10
Gene Amplification Technology (GAT) 10
Hybrid Capture 10
Isothermal DNA Amplification Techniques 11
Rolling circle Amplification in Diagnostics 11
Ican Isothermal Gene Amplification Technology 11
BioHelix HDA Technology 11
Other Amplification Technologies 11
Signal Amplification Technology 11
Transcription Mediated Amplification 12
DNA cleavage-based signal amplification 12
Ramification Amplification Method 12
4. END USE MARKET ANALYSIS 13
Medical and Diagnostics 13
Role of Amplification Technology in the Diagnoses of
Infectious Diseases 13
Diagnosis of Infectious Diseases by PCR 13
Detection of Antimicrobial Resistance 14
PCR Based Nucleic Acid Amplification for Detection of
Antimicrobial Agents 14
Nucleic Acid Amplification Testing (NAT) 14
Nucleic Acid Amplification Methods 15
DNA Amplification Technology in the Diagnosis of Infectious
Diseases 15
Forensic and Paternity Testing 15
Food Safety 16
5. PRODUCT INNOVATIONS/LAUNCHES 17
DuPont Qualicon Launches New BAX® System Real-Time PCR Assay 17
Rubicon Genomics Launches PicoPlex Single Cell WGA Kit 17
NuGEN Unveils WT-OvationTM RNA Amplification System for Whole
-Transcriptome Gene Expression Analysis 17
DuPont Qualicon Obtains Approval from Russian Federal Consumer
Rights Protection and Human Health Control Service for BAX™
System 18
DuPont Qualicon Receives Approval from the General
Administration of Quality Supervision, Inspection and
Quarantine for BAX® system 18
Seegene Enters into Partnership with Shimadzu 19
Bio-Rad Launches New CFX96 PCR Detection System 19
6. PRODUCT INNOVATIONS/LAUNCHES IN RECENT PAST - A PERSPECTIVE
BUILDER 20
Roche Introduces Genome Sequencer FLX System 20
QIAGEN Launches TopTaq DNA Polymerase 20
Applied Biosystems Introduces TaqMan Array Human MicroRNA Panel 20
Spartan Introduces Spartan DX 21
Applied Biosystems Launches Forensic Tools 21
Applied Biosystems Introduces StepOne Real-Time PCR System 21
Sigma-Aldrich Unveils GenomePlex Tissue Whole Genome
Amplification Kit 22
QIAGEN Rolls Out Wide RNAi and SYBR® Green-based RT- PCR 22
Applied Biosystems Launches 7500 Fast Real-Time PCR System 22
Applied Biosystems Launches 9800 Fast PCR System 23
7900HT Fast Real-Time PCR System from Applied Biosystems 23
Enzo Life Sciences Introduces New Advanced Amplification
Technology 23
Applied Biosystems Unveils AmpFSTR® Yfiler™ PCR Amplification Kit 24
Amersham Launches GenomiPhi 24
Rubicon Genomics Launches GenomePlex WGA 24
Agilent Introduces Amplification Kit 24
Linden Introduces Snapshot mRNA 25
Rubicon Launches OmniPlex™ 25
7. RECENT INDUSTRY ACTIVITY 26
QIAGEN Acquires Rights to 70 Molecular Food Safety Tests from ifp 26
Life Technologies to Acquire Geneart 26
Thermo Fisher Scientific Takes Over Finnzymes 26
Abbott Inks Agreement with GlaxoSmithKline for Developing
Molecular Diagnostic Test 26
DXS Purchases License for P13K Gene from Johns Hopkins University 27
Qiagen Acquires SABiosciences 27
DuPont Qualicon Obtains License from DxS for Scorpions®
Technology 27
BD Takes Over HandyLab 28
Life Technologies Takes Over BioTrove 28
Merck Merges with Schering-Plough 28
QIAGEN Acquires Licenses from Idaho Technology and Roche 28
Response Genetics Inks Non-Exclusive Agreement with Roche
Diagnostics 29
Invitrogen Announces Merger with Applied Biosystems 29
Hologic Acquires Third Wave Technologies 29
BIOTECON Acquires Roche's Technology License 29
QIAGEN Signs a Global Licensing Agreement with BioHelix 30
BioTrove and Gene Express Receive NIH Grant for Innovative
Bio-experimentation 30
8. CORPORATE ACTIVITY IN THE RECENT PAST - A PERSPECTIVE BUILDER 31
SuperArray Bioscience Inks License Agreement with Applied
Biosystems 31
Merck Capital Takes Over Minority Interest in High Throughput
Genomics 31
NuGEN Enters into a Service Agreement with ExonHit 31
Qiagen Enters into License Agreements with Roche and Ortho-
Clinical 32
Agilent Takes Over Stratagene 32
Eiken Chemical Inks Licensing Agreement with Meridian Bioscience 32
Sigma-Aldrich Acquires JRH 33
Sigma-Aldrich Snaps Up Proligo 33
Beckman Acquires Agencourt 33
Roche Diagnostics and Applera Corporation Expand PCR Licensing
Program 33
Mount and Hamilton Receive Patent 33
Invitrogen Bags License from Applied Biosystems 33
OriGene to Access TrueClone 34
Orchid BioSciences to Turn into Orchid Cellmark 34
QIAGEN Purchases Assets of Molecular Staging 34
Cepheid, Applied Biosystems and Celera Diagnostics Sign Patent
License Agreement 34
Abbott Enters into Agreement with BioGenex 35
Roche Inks Licensing Agreement with Incyte Corp 35
Rubicon Genomics Signs Licensing Agreement with Sigma-Aldrich 35
BioMérieux Teams-up with Cepheid 35
Molecular Staging Collaborates with Eli Lilly 35
Pacific Biometrics Inc. Receives Gene Amplification Patent 35
Rubicon Introduces Service for Genome Amplification 36
Takara Obtains Patent for New Amplification Method 36
9. FOCUS ON SELECT GLOBAL PLAYERS 37
Abbott Laboratories (US) 37
Becton, Dickinson and Company (US) 37
bioMérieux (France) 37
Bio-Rad Laboratories (US) 38
Cepheid (US) 38
Life Technologies Corp. (US) 38
QIAGEN N.V. (The Netherlands) 39
Roche Diagnostics (Switzerland) 39
Rubicon Genomics (US) 40
Takara Bio, Inc. 40
10. GLOBAL MARKET PERSPECTIVE 41
Table 1: World Recent Past, Current & Future Market Analysis
for Gene Amplification Technologies by Geographic Region - US,
Canada, Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2007 through 2015 (includes corresponding Graph/Chart) 41
Table 2: World Historic Review for Gene Amplification
Technologies by Geographic Region - US, Canada, Japan, Europe,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2000 through 2006
(includes corresponding Graph/Chart) 42
Table 3: World 11-Year Perspective for Gene Amplification
Technologies by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe, and Rest of World
Markets for Years 2005, 2010 & 2015 (includes corresponding
Graph/Chart) 43
Table 4: World Recent Past, Current & Future Market Analysis
for Polymerase Chain Reaction (PCR) by Geographic Region - US,
Canada, Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2007 through 2015 (includes corresponding Graph/Chart) 44
Table 5: World Historic Review for Polymerase Chain Reaction
(PCR) by Geographic Region - US, Canada, Japan, Europe, and
Rest of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2006 (includes
corresponding Graph/Chart) 45
Table 6: World 11-Year Perspective for Polymerase Chain
Reaction (PCR) by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe, and Rest of World
Markets for Years 2005, 2010 & 2015 (includes corresponding
Graph/Chart) 46
Table 7: World Recent Past, Current & Future Market Analysis
for Other Gene Amplification Technologies by Geographic Region-
US, Canada, Japan, Europe, and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2007 through 2015 (includes corresponding
Graph/Chart) 47
Table 8: World Historic Review for Other Gene Amplification
Technologies by Geographic Region - US, Canada, Japan, Europe,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2000 through 2006
(includes corresponding Graph/Chart) 48
Table 9: World 11-Year Perspective for Other Gene
Amplification Technologies by Geographic Region - Percentage
Breakdown of Dollar Sales for US, Canada, Japan, Europe, and
Rest of World Markets for Years 2005, 2010 & 2015 (includes
corresponding Graph/Chart) 49
11. THE UNITED STATES 50
A.Market Analysis 50
Real-Time PCR Market in North America: A Primer 50
Table 10: Leading Suppliers of Individual qPCR Reagents in
North America (2008): Percentage Dollar Share Breakdown of
Invitrogen, Applied Biosystems, Roche Applied, Bio-Rad/ MJ,
BD Clontech, Promega, Amblon, NEB, Qiagen, and Others
(includes corresponding Graph/Chart) 50
Key Factors (Ranked in Order) in Selection of Real-Time/
qPCR Platforms Manufacturers 51
Top 10 Research Applications of Real-Time Quantitative PCR
(qPCR) in North America 51
B.Market Analytics 52
Table 11: US Recent Past, Current & Future Analysis for Gene
Amplification Technologies by Segment - Polymerase Chain
Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2007 through 2015 (includes corresponding
Graph/Chart) 52
Table 12: US Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2000
through 2006 (includes corresponding Graph/Chart) 53
Table 13: US 11-Year Perspective for Gene Amplification
Technologies by Segment - Percentage Breakdown of Dollar
Sales for Polymerase Chain Reaction (PCR) and Other Gene
Amplification Markets for 2005, 2010 & 2015 53
12. CANADA 54
Market Analysis 54
Table 14: Canadian Recent Past, Current & Future Analysis
for Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2007 through 2015 (includes corresponding
Graph/Chart) 54
Table 15: Canadian Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2000
through 2006 (includes corresponding Graph/Chart) 55
Table 16: Canadian 11-Year Perspective for Gene
Amplification Technologies by Segment - Percentage Breakdown
of Dollar Sales for Polymerase Chain Reaction (PCR) and
Other Gene Amplification Markets for 2005, 2010 & 2015 55
13. JAPAN 56
Market Analysis 56
Table 17: Japanese Recent Past, Current & Future Analysis
for Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2007 through 2015 (includes corresponding
Graph/Chart) 56
Table 18: Japanese Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2000
through 2006 (includes corresponding Graph/Chart) 57
Table 19: Japanese 11-Year Perspective for Gene
Amplification Technologies by Segment - Percentage Breakdown
of Dollar Sales for Polymerase Chain Reaction (PCR) and
Other Gene Amplification Markets for 2005, 2010 & 2015 57
14. EUROPE 58
Market Analysis 58
Table 20: European Recent Past, Current & Future Analysis
for Gene Amplification Technologies by Geographic Region -
France, Germany, UK, Italy, and Rest of Europe Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2007 through 2015 (includes corresponding
Graph/Chart) 58
Table 21: European Historic Review for Gene Amplification
Technologies by Geographic Region - France, Germany, UK,
Italy, and Rest of Europe Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2000
through 2006 (includes corresponding Graph/Chart) 59
Table 22: European 11-Year Perspective for Gene
Amplification Technologies by Geographic Region - Percentage
Breakdown of Dollar Sales for France, Germany, UK, Italy, &
Rest of Europe Markets for Years 2005, 2010 & 2015 (includes
corresponding Graph/Chart) 60
Table 23: European Recent Past, Current & Future Analysis
for Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2007 through 2015 (includes corresponding
Graph/Chart) 61
Table 24: European Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2000
through 2006 (includes corresponding Graph/Chart) 62
Table 25: European 11-Year Perspective for Gene
Amplification Technologies by Segment - Percentage Breakdown
of Dollar Sales for Polymerase Chain Reaction (PCR) and
Other Gene Amplification Markets for 2005, 2010 & 2015 62
14a. FRANCE 63
Market Analysis 63
Table 26: French Recent Past, Current & Future Analysis for
Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2007 through 2015 (includes corresponding
Graph/Chart) 63
Table 27: French Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2000
through 2006 (includes corresponding Graph/Chart) 64
Table 28: French 11-Year Perspective for Gene Amplification
Technologies by Segment - Percentage Breakdown of Dollar
Sales for Polymerase Chain Reaction (PCR) and Other Gene
Amplification Markets for 2005, 2010 & 2015 64
14b. GERMANY 65
Market Analysis 65
Table 29: German Recent Past, Current & Future Analysis for
Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2007 through 2015 (includes corresponding
Graph/Chart) 65
Table 30: German Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2000
through 2006 (includes corresponding Graph/Chart) 66
Table 31: German 11-Year Perspective for Gene Amplification
Technologies by Segment - Percentage Breakdown of Dollar
Sales for Polymerase Chain Reaction (PCR) and Other Gene
Amplification Markets for 2005, 2010 & 2015 66
14c. ITALY 67
Market Analysis 67
Table 32: Italian Recent Past, Current & Future Analysis for
Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2007 through 2015 (includes corresponding
Graph/Chart) 67
Table 33: Italian Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2000
through 2006 (includes corresponding Graph/Chart) 68
Table 34: Italian 11-Year Perspective for Gene Amplification
Technologies by Segment - Percentage Breakdown of Dollar
Sales for Polymerase Chain Reaction (PCR) and Other Gene
Amplification Markets for 2005, 2010 & 2015 68
14d. UNITED KINGDOM 69
Market Analysis 69
Table 35: UK Recent Past, Current & Future Analysis for Gene
Amplification Technologies by Segment - Polymerase Chain
Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2007 through 2015 (includes corresponding
Graph/Chart) 69
Table 36: UK Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2000
through 2006 (includes corresponding Graph/Chart) 70
Table 37: UK 11-Year Perspective for Gene Amplification
Technologies by Segment - Percentage Breakdown of Dollar
Sales for Polymerase Chain Reaction (PCR) and Other Gene
Amplification Markets for 2005, 2010 & 2015 70
14e. REST OF EUROPE 71
Market Analysis 71
Table 38: Rest of Europe Market for Gene Amplification
Technologies - Recent Past, Current & Future Market Analysis
by Segment for Polymerase Chain Reaction (PCR) and Other
Gene Amplification Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2007 through
2015 (includes corresponding Graph/Chart) 71
Table 39: Rest of Europe Historic Review for Gene
Amplification Technologies by Segment - Polymerase Chain
Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2000 through 2006 (includes corresponding
Graph/Chart) 72
Table 40: Rest of Europe 11-Year Perspective for Gene
Amplification Technologies by Segment - Percentage Breakdown
of Dollar Sales for Polymerase Chain Reaction (PCR) and
Other Gene Amplification Markets for 2005, 2010 & 2015 72
15. REST OF WORLD 73
Market Analysis 73
Table 41: Rest of World Market for Gene Amplification
Technologies - Recent Past, Current & Future Market Analysis
by Segment for Polymerase Chain Reaction (PCR) and Other
Gene Amplification Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2007 through
2015 (includes corresponding Graph/Chart) 73
Table 42: Rest of World Historic Review for Gene
Amplification Technologies by Segment - Polymerase Chain
Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2000 through 2006 (includes corresponding
Graph/Chart) 74
Table 43: Rest of World 11-Year Perspective for Gene
Amplification Technologies by Segment - Percentage Breakdown
of Dollar Sales for Polymerase Chain Reaction (PCR) and
Other Gene Amplification Markets for 2005, 2010 & 2015 74
COMPETITIVE LANDSCAPE
Total Companies Profiled: 91 (including Divisions/Subsidiaries - 106)
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Region/Country Players
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The United States 62
Canada 4
Japan 4
Europe 34
France 3
Germany 5
The United Kingdom 15
Italy 1
Spain 2
Rest of Europe 8
Asia-Pacific (Excluding Japan) 2
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