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Gene Amplification Technologies - Global Strategic Business Report

Price:
USD $4,500.00
ISBN/SKU #:
GIA-MCP1102
Research Group:
Global Industry Analysts
Date of Publication:
January 2011
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Summary

This report analyzes the worldwide markets for Gene Amplification Technologies in US$ Million by the following Product segments: Polymerase Chain Reaction, and Other Gene Amplification Technologies. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2007 through 2015. Also, a seven-year historic analysis is provided for these markets.The report profiles 91 companies including many key and niche players such as Abbott Laboratories, Becton, Dickinson and Company, bioMerieux, Bio-Rad Laboratories, Cepheid,  Life Technologies Corp., QIAGEN N.V, Roche Diagnostics, Rubicon Genomics, and Takara Bio, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources. 

TABLE OF CONTENTS

GENE AMPLIFICATION TECHNOLOGIES 						MCP-1102
A GLOBAL STRATEGIC BUSINESS REPORT	


                                            CONTENTS



  1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS                    1
      Study Reliability and Reporting Limitations                       1
      Disclaimers                                                       2
      Data Interpretation & Reporting Level                             2
       Quantitative Techniques & Analytics                              3
      Product Definitions and Scope of Study                            3
       Definitions                                                      3
        Polymerase Chain Reaction                                       3
        Other Gene Amplification Technologies                           3

  2. INDUSTRY OVERVIEW                                                  4
      PCR Dominates Amplification Technologies                          4
      Miniaturization - The Next Big Focus                              4
      Critical in Diagnostic Procedures                                 5
      Leading Players                                                   5
       
  3. TECHNOLOGY OVERVIEW                                                6
      Definition of Gene Amplification                                  6
      Target vs. Signal Amplification                                   6
      Available Types of Gene Amplification Technologies                6
       Polymerase Chain Reaction                                        6
        Reagents and Equipment required for PCR                         7
        Reaction Steps                                                  7
         Denaturation                                                   7
         Annealing                                                      7
         Extension                                                      7
        Detection of Amplified Product/DNA                              8
        (Q&Q) PCR                                                       8
        Reverse Transcriptase PCR (RT-PCR)                              9
       Alternative Technologies to PCR                                  9
        OmniPlex                                                        9
        Strand Displacement Amplification                               10
        Ligase Chain Reaction                                           10
         LCR Involves a Cyclic Two-Step Reaction                        10
        Gene Amplification Technology (GAT)                             10
        Hybrid Capture                                                  10
        Isothermal DNA Amplification Techniques                         11
         Rolling circle Amplification in Diagnostics                    11
         Ican Isothermal Gene Amplification Technology                  11
         BioHelix HDA Technology                                        11
        Other Amplification Technologies                                11
         Signal Amplification Technology                                11
         Transcription Mediated Amplification                           12
         DNA cleavage-based signal amplification                        12
         Ramification Amplification Method                              12
  4. END USE MARKET ANALYSIS                                            13
      Medical and Diagnostics                                           13
       Role of Amplification Technology in the Diagnoses of
        Infectious Diseases                                             13
       Diagnosis of Infectious Diseases by PCR                          13
        Detection of Antimicrobial Resistance                           14
         PCR Based Nucleic Acid Amplification for Detection of
          Antimicrobial Agents                                          14
        Nucleic Acid Amplification Testing (NAT)                        14
         Nucleic Acid Amplification Methods                             15
        DNA Amplification Technology in the Diagnosis of Infectious
         Diseases                                                       15
      Forensic and Paternity Testing                                    15
      Food Safety                                                       16
    
  5. PRODUCT INNOVATIONS/LAUNCHES                                       17
      DuPont Qualicon Launches New BAX® System Real-Time PCR Assay      17
      Rubicon Genomics Launches PicoPlex Single Cell WGA Kit            17
      NuGEN Unveils WT-OvationTM RNA Amplification System for Whole
       -Transcriptome Gene Expression Analysis                          17
      DuPont Qualicon Obtains Approval from Russian Federal Consumer
       Rights Protection and Human Health Control Service for BAX™
        System                                                          18
      DuPont Qualicon Receives Approval from the General
       Administration of Quality Supervision, Inspection and
        Quarantine for BAX® system                                      18
      Seegene Enters into Partnership with Shimadzu                     19
      Bio-Rad Launches New CFX96 PCR Detection System                   19

  6. PRODUCT INNOVATIONS/LAUNCHES IN RECENT PAST - A PERSPECTIVE
     BUILDER                                                            20
      Roche Introduces Genome Sequencer FLX System                      20
      QIAGEN Launches TopTaq DNA Polymerase                             20
      Applied Biosystems Introduces TaqMan Array Human MicroRNA Panel   20
      Spartan Introduces Spartan DX                                     21
      Applied Biosystems Launches Forensic Tools                        21
      Applied Biosystems Introduces StepOne Real-Time PCR System        21
      Sigma-Aldrich Unveils GenomePlex Tissue Whole Genome
       Amplification Kit                                                22
      QIAGEN Rolls Out Wide RNAi and SYBR® Green-based RT- PCR          22
      Applied Biosystems Launches 7500 Fast Real-Time PCR System        22
      Applied Biosystems Launches 9800 Fast PCR System                  23
      7900HT Fast Real-Time PCR System from Applied Biosystems          23
      Enzo Life Sciences Introduces New Advanced Amplification
       Technology                                                       23
      Applied Biosystems Unveils AmpFSTR® Yfiler™ PCR Amplification Kit 24
      Amersham Launches GenomiPhi                                       24
      Rubicon Genomics Launches GenomePlex WGA                          24
      Agilent Introduces Amplification Kit                              24
      Linden Introduces Snapshot mRNA                                   25
      Rubicon Launches OmniPlex™                                        25
    
  7. RECENT INDUSTRY ACTIVITY                                           26
      QIAGEN Acquires Rights to 70 Molecular Food Safety Tests from ifp 26
      Life Technologies to Acquire Geneart                              26
      Thermo Fisher Scientific Takes Over Finnzymes                     26
      Abbott Inks Agreement with GlaxoSmithKline for Developing
       Molecular Diagnostic Test                                        26
      DXS Purchases License for P13K Gene from Johns Hopkins University 27
      Qiagen Acquires SABiosciences                                     27
      DuPont Qualicon Obtains License from DxS for Scorpions®
       Technology                                                       27
      BD Takes Over HandyLab                                            28
      Life Technologies Takes Over BioTrove                             28
      Merck Merges with Schering-Plough                                 28
      QIAGEN Acquires Licenses from Idaho Technology and Roche          28
      Response Genetics Inks Non-Exclusive Agreement with Roche
       Diagnostics                                                      29
      Invitrogen Announces Merger with Applied Biosystems               29
      Hologic Acquires Third Wave Technologies                          29
      BIOTECON Acquires Roche's Technology License                      29
      QIAGEN Signs a Global Licensing Agreement with BioHelix           30
      BioTrove and Gene Express Receive NIH Grant for Innovative
       Bio-experimentation                                              30

  8. CORPORATE ACTIVITY IN THE RECENT PAST - A PERSPECTIVE BUILDER      31
      SuperArray Bioscience Inks License Agreement with Applied
       Biosystems                                                       31
      Merck Capital Takes Over Minority Interest in High Throughput
       Genomics                                                         31
      NuGEN Enters into a Service Agreement with ExonHit                31
      Qiagen Enters into License Agreements with Roche and Ortho-
       Clinical                                                         32
      Agilent Takes Over Stratagene                                     32
      Eiken Chemical Inks Licensing Agreement with Meridian Bioscience  32
      Sigma-Aldrich Acquires JRH                                        33
      Sigma-Aldrich Snaps Up Proligo                                    33
      Beckman Acquires Agencourt                                        33
      Roche Diagnostics and Applera Corporation Expand PCR Licensing
       Program                                                          33
      Mount and Hamilton Receive Patent                                 33
      Invitrogen Bags License from Applied Biosystems                   33
      OriGene to Access TrueClone                                       34
      Orchid BioSciences to Turn into Orchid Cellmark                   34
      QIAGEN Purchases Assets of Molecular Staging                      34
      Cepheid, Applied Biosystems and Celera Diagnostics Sign Patent
       License Agreement                                                34
      Abbott Enters into Agreement with BioGenex                        35
      Roche Inks Licensing Agreement with Incyte Corp                   35
      Rubicon Genomics Signs Licensing Agreement with Sigma-Aldrich     35
      BioMérieux Teams-up with Cepheid                                  35
      Molecular Staging Collaborates with Eli Lilly                     35
      Pacific Biometrics Inc. Receives Gene Amplification Patent        35
      Rubicon Introduces Service for Genome Amplification               36
      Takara Obtains Patent for New Amplification Method                36
     
  9. FOCUS ON SELECT GLOBAL PLAYERS                                     37
      Abbott Laboratories (US)                                          37
      Becton, Dickinson and Company (US)                                37
      bioMérieux (France)                                               37
      Bio-Rad Laboratories (US)                                         38
      Cepheid (US)                                                      38
      Life Technologies Corp. (US)                                      38
      QIAGEN N.V. (The Netherlands)                                     39
      Roche Diagnostics (Switzerland)                                   39
      Rubicon Genomics (US)                                             40
      Takara Bio, Inc.                                                  40
   
  10. GLOBAL MARKET PERSPECTIVE                                         41
      Table 1: World Recent Past, Current & Future Market Analysis
      for Gene Amplification Technologies by Geographic Region - US,
      Canada, Japan, Europe, and Rest of World Markets Independently
      Analyzed with Annual Sales Figures in US$ Million for Years
      2007 through 2015 (includes corresponding Graph/Chart)            41

      Table 2: World Historic Review for Gene Amplification
      Technologies by Geographic Region - US, Canada, Japan, Europe,
      and Rest of World Markets Independently Analyzed with Annual
      Sales Figures in US$ Million for Years 2000 through 2006
      (includes corresponding Graph/Chart)                              42

      Table 3: World 11-Year Perspective for Gene Amplification
      Technologies by Geographic Region - Percentage Breakdown of
      Dollar Sales for US, Canada, Japan, Europe, and Rest of World
      Markets for Years 2005, 2010 & 2015 (includes corresponding
      Graph/Chart)                                                      43

      Table 4: World Recent Past, Current & Future Market Analysis
      for Polymerase Chain Reaction (PCR) by Geographic Region - US,
      Canada, Japan, Europe, and Rest of World Markets Independently
      Analyzed with Annual Sales Figures in US$ Million for Years
      2007 through 2015 (includes corresponding Graph/Chart)            44

      Table 5: World Historic Review for Polymerase Chain Reaction
      (PCR) by Geographic Region - US, Canada, Japan, Europe, and
      Rest of World Markets Independently Analyzed with Annual Sales
      Figures in US$ Million for Years 2000 through 2006 (includes
      corresponding Graph/Chart)                                        45

      Table 6: World 11-Year Perspective for Polymerase Chain
      Reaction (PCR) by Geographic Region - Percentage Breakdown of
      Dollar Sales for US, Canada, Japan, Europe, and Rest of World
      Markets for Years 2005, 2010 & 2015 (includes corresponding
      Graph/Chart)                                                      46

      Table 7: World Recent Past, Current & Future Market Analysis
      for Other Gene Amplification Technologies by Geographic Region- 
      US, Canada, Japan, Europe, and Rest of World Markets
      Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2007 through 2015 (includes corresponding
      Graph/Chart)                                                      47

      Table 8: World Historic Review for Other Gene Amplification
      Technologies by Geographic Region - US, Canada, Japan, Europe,
      and Rest of World Markets Independently Analyzed with Annual
      Sales Figures in US$ Million for Years 2000 through 2006
      (includes corresponding Graph/Chart)                              48

      Table 9: World 11-Year Perspective for Other Gene
      Amplification Technologies by Geographic Region - Percentage
      Breakdown of Dollar Sales for US, Canada, Japan, Europe, and
      Rest of World Markets for Years 2005, 2010 & 2015 (includes
      corresponding Graph/Chart)                                        49
     
  11. THE UNITED STATES                                                 50
      A.Market Analysis                                                 50
        Real-Time PCR Market in North America: A Primer                 50
         Table 10: Leading Suppliers of Individual qPCR Reagents in
         North America (2008): Percentage Dollar Share Breakdown of
         Invitrogen, Applied Biosystems, Roche Applied, Bio-Rad/ MJ,
         BD Clontech, Promega, Amblon, NEB, Qiagen, and Others
         (includes corresponding Graph/Chart)                           50
         Key Factors (Ranked in Order) in Selection of Real-Time/
          qPCR Platforms Manufacturers                                  51
         Top 10 Research Applications of Real-Time Quantitative PCR
          (qPCR) in North America                                       51
      B.Market Analytics                                                52
        Table 11: US Recent Past, Current & Future Analysis for Gene
        Amplification Technologies by Segment - Polymerase Chain
        Reaction (PCR) and Other Gene Amplification Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2007 through 2015 (includes corresponding
        Graph/Chart)                                                    52

        Table 12: US Historic Review for Gene Amplification
        Technologies by Segment - Polymerase Chain Reaction (PCR)
        and Other Gene Amplification Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2000
        through 2006 (includes corresponding Graph/Chart)               53

        Table 13: US 11-Year Perspective for Gene Amplification
        Technologies by Segment - Percentage Breakdown of Dollar
        Sales for Polymerase Chain Reaction (PCR) and Other Gene
        Amplification Markets for 2005, 2010 & 2015                     53
   
  12. CANADA                                                            54
       Market Analysis                                                  54
        Table 14: Canadian Recent Past, Current & Future Analysis
        for Gene Amplification Technologies by Segment - Polymerase
        Chain Reaction (PCR) and Other Gene Amplification Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2007 through 2015 (includes corresponding
        Graph/Chart)                                                    54

        Table 15: Canadian Historic Review for Gene Amplification
        Technologies by Segment - Polymerase Chain Reaction (PCR)
        and Other Gene Amplification Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2000
        through 2006 (includes corresponding Graph/Chart)               55

        Table 16: Canadian 11-Year Perspective for Gene
        Amplification Technologies by Segment - Percentage Breakdown
        of Dollar Sales for Polymerase Chain Reaction (PCR) and
        Other Gene Amplification Markets for 2005, 2010 & 2015          55
  
  13. JAPAN                                                             56
       Market Analysis                                                  56
        Table 17: Japanese Recent Past, Current & Future Analysis
        for Gene Amplification Technologies by Segment - Polymerase
        Chain Reaction (PCR) and Other Gene Amplification Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2007 through 2015 (includes corresponding
        Graph/Chart)                                                    56

        Table 18: Japanese Historic Review for Gene Amplification
        Technologies by Segment - Polymerase Chain Reaction (PCR)
        and Other Gene Amplification Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2000
        through 2006 (includes corresponding Graph/Chart)               57

        Table 19: Japanese 11-Year Perspective for Gene
        Amplification Technologies by Segment - Percentage Breakdown
        of Dollar Sales for Polymerase Chain Reaction (PCR) and
        Other Gene Amplification Markets for 2005, 2010 & 2015          57
   
  14. EUROPE                                                            58
       Market Analysis                                                  58
        Table 20: European Recent Past, Current & Future Analysis
        for Gene Amplification Technologies by Geographic Region -
        France, Germany, UK, Italy, and Rest of Europe Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2007 through 2015 (includes corresponding
        Graph/Chart)                                                    58

        Table 21: European Historic Review for Gene Amplification
        Technologies by Geographic Region - France, Germany, UK,
        Italy, and Rest of Europe Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2000
        through 2006 (includes corresponding Graph/Chart)               59

        Table 22: European 11-Year Perspective for Gene
        Amplification Technologies by Geographic Region - Percentage
        Breakdown of Dollar Sales for France, Germany, UK, Italy, &
        Rest of Europe Markets for Years 2005, 2010 & 2015 (includes
        corresponding Graph/Chart)                                      60

        Table 23: European Recent Past, Current & Future Analysis
        for Gene Amplification Technologies by Segment - Polymerase
        Chain Reaction (PCR) and Other Gene Amplification Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2007 through 2015 (includes corresponding
        Graph/Chart)                                                    61

        Table 24: European Historic Review for Gene Amplification
        Technologies by Segment - Polymerase Chain Reaction (PCR)
        and Other Gene Amplification Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2000
        through 2006 (includes corresponding Graph/Chart)               62

        Table 25: European 11-Year Perspective for Gene
        Amplification Technologies by Segment - Percentage Breakdown
        of Dollar Sales for Polymerase Chain Reaction (PCR) and
        Other Gene Amplification Markets for 2005, 2010 & 2015          62
   
  14a. FRANCE                                                           63
       Market Analysis                                                  63
        Table 26: French Recent Past, Current & Future Analysis for
        Gene Amplification Technologies by Segment - Polymerase
        Chain Reaction (PCR) and Other Gene Amplification Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2007 through 2015 (includes corresponding
        Graph/Chart)                                                    63

        Table 27: French Historic Review for Gene Amplification
        Technologies by Segment - Polymerase Chain Reaction (PCR)
        and Other Gene Amplification Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2000
        through 2006 (includes corresponding Graph/Chart)               64

        Table 28: French 11-Year Perspective for Gene Amplification
        Technologies by Segment - Percentage Breakdown of Dollar
        Sales for Polymerase Chain Reaction (PCR) and Other Gene
        Amplification Markets for 2005, 2010 & 2015                     64
  
  14b. GERMANY                                                          65
       Market Analysis                                                  65
        Table 29: German Recent Past, Current & Future Analysis for
        Gene Amplification Technologies by Segment - Polymerase
        Chain Reaction (PCR) and Other Gene Amplification Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2007 through 2015 (includes corresponding
        Graph/Chart)                                                    65

        Table 30: German Historic Review for Gene Amplification
        Technologies by Segment - Polymerase Chain Reaction (PCR)
        and Other Gene Amplification Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2000
        through 2006 (includes corresponding Graph/Chart)               66

        Table 31: German 11-Year Perspective for Gene Amplification
        Technologies by Segment - Percentage Breakdown of Dollar
        Sales for Polymerase Chain Reaction (PCR) and Other Gene
        Amplification Markets for 2005, 2010 & 2015                     66
    
  14c. ITALY                                                            67
       Market Analysis                                                  67
        Table 32: Italian Recent Past, Current & Future Analysis for
        Gene Amplification Technologies by Segment - Polymerase
        Chain Reaction (PCR) and Other Gene Amplification Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2007 through 2015 (includes corresponding
        Graph/Chart)                                                    67

        Table 33: Italian Historic Review for Gene Amplification
        Technologies by Segment - Polymerase Chain Reaction (PCR)
        and Other Gene Amplification Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2000
        through 2006 (includes corresponding Graph/Chart)               68

        Table 34: Italian 11-Year Perspective for Gene Amplification
        Technologies by Segment - Percentage Breakdown of Dollar
        Sales for Polymerase Chain Reaction (PCR) and Other Gene
        Amplification Markets for 2005, 2010 & 2015                     68
   
  14d. UNITED KINGDOM                                                   69
       Market Analysis                                                  69
        Table 35: UK Recent Past, Current & Future Analysis for Gene
        Amplification Technologies by Segment - Polymerase Chain
        Reaction (PCR) and Other Gene Amplification Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2007 through 2015 (includes corresponding
        Graph/Chart)                                                    69

        Table 36: UK Historic Review for Gene Amplification
        Technologies by Segment - Polymerase Chain Reaction (PCR)
        and Other Gene Amplification Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2000
        through 2006 (includes corresponding Graph/Chart)               70

        Table 37: UK 11-Year Perspective for Gene Amplification
        Technologies by Segment - Percentage Breakdown of Dollar
        Sales for Polymerase Chain Reaction (PCR) and Other Gene
        Amplification Markets for 2005, 2010 & 2015                     70
    
  14e. REST OF EUROPE                                                   71
       Market Analysis                                                  71
        Table 38: Rest of Europe Market for Gene Amplification
        Technologies - Recent Past, Current & Future Market Analysis
        by Segment for Polymerase Chain Reaction (PCR) and Other
        Gene Amplification Markets Independently Analyzed with
        Annual Sales Figures in US$ Million for Years 2007 through
        2015 (includes corresponding Graph/Chart)                       71

        Table 39: Rest of Europe Historic Review for Gene
        Amplification Technologies by Segment - Polymerase Chain
        Reaction (PCR) and Other Gene Amplification Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2000 through 2006 (includes corresponding
        Graph/Chart)                                                    72

        Table 40: Rest of Europe 11-Year Perspective for Gene
        Amplification Technologies by Segment - Percentage Breakdown
        of Dollar Sales for Polymerase Chain Reaction (PCR) and
        Other Gene Amplification Markets for 2005, 2010 & 2015          72
    
  15. REST OF WORLD                                                     73
       Market Analysis                                                  73
        Table 41: Rest of World Market for Gene Amplification
        Technologies - Recent Past, Current & Future Market Analysis
        by Segment for Polymerase Chain Reaction (PCR) and Other
        Gene Amplification Markets Independently Analyzed with
        Annual Sales Figures in US$ Million for Years 2007 through
        2015 (includes corresponding Graph/Chart)                       73

        Table 42: Rest of World Historic Review for Gene
        Amplification Technologies by Segment - Polymerase Chain
        Reaction (PCR) and Other Gene Amplification Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2000 through 2006 (includes corresponding
        Graph/Chart)                                                    74

        Table 43: Rest of World 11-Year Perspective for Gene
        Amplification Technologies by Segment - Percentage Breakdown
        of Dollar Sales for Polymerase Chain Reaction (PCR) and
        Other Gene Amplification Markets for 2005, 2010 & 2015          74
     

 COMPETITIVE LANDSCAPE

    Total Companies Profiled: 91 (including Divisions/Subsidiaries - 106)

     ------------------------------------------
     Region/Country                     Players
     ------------------------------------------
     The United States                     62
     Canada                                 4
     Japan                                  4
     Europe                                34
      France                                3
      Germany                               5
      The United Kingdom                   15
      Italy                                 1
      Spain                                 2
      Rest of Europe                        8
     Asia-Pacific (Excluding Japan)         2
     ------------------------------------------

 


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Number of Pages: 466

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